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pro-HGF [extracellular region]
Stable Identifier
R-HSA-6800218
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
HGF(32-728), Hepatocyte growth factor alpha chain, Scatter factor, SF, Hepatopoeitin A
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
pro-HGF [extracellular region] (Homo sapiens)
HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
pro-HGF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14210 HGF
Gene Names
HGF, HPTA
Chain
signal peptide:1-31, chain:32-494, chain:495-728
Reference Genes
BioGPS Gene:3082 HGF
COSMIC (genes):HGF HGF
CTD Gene:3082 HGF
dbSNP Gene:3082 HGF
ENSEMBL:ENSG00000019991 HGF
HGNC:4893 HGF
KEGG Gene (Homo sapiens):3082 HGF
Monarch:3082 HGF
NCBI Gene:3082 HGF
OMIM:142409 HGF
UCSC:P14210 HGF
Reference Transcript
RefSeq:XM_017012098.1 HGF
RefSeq:NM_001010931.2 HGF
RefSeq:NM_001010932.2 HGF
RefSeq:XM_011516115.2 HGF
RefSeq:NM_001010934.2 HGF
RefSeq:XM_017012097.1 HGF
RefSeq:NM_000601.5 HGF
RefSeq:NM_001010933.2 HGF
RefSeq:XM_006715956.2 HGF
Other Identifiers
0006420110
1095_s_at
11730068_a_at
11732351_at
11732746_a_at
11732747_at
1340_s_at
17059165
209960_at
209961_s_at
210755_at
210997_3p_at
210997_at
210998_s_at
3058945
3058946
3058947
3058954
3058955
3058956
3058957
3058958
3058959
3058960
3058961
3058963
3058965
3058967
3058968
3058972
3058973
3058974
3058979
3058981
3058982
3058984
3058988
3058989
3082
8140556
A_23_P93780
A_23_P93787
A_24_P944788
A_33_P3276713
A_33_P3276718
GE62425
GO:0000165
GO:0000187
GO:0000278
GO:0000902
GO:0001837
GO:0001889
GO:0001934
GO:0002576
GO:0003674
GO:0004252
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0006259
GO:0006464
GO:0006508
GO:0006810
GO:0006914
GO:0006950
GO:0007005
GO:0007049
GO:0007165
GO:0007267
GO:0008083
GO:0008150
GO:0008219
GO:0008233
GO:0008283
GO:0009056
GO:0009058
GO:0010507
GO:0014068
GO:0016020
GO:0016192
GO:0019221
GO:0030154
GO:0030212
GO:0030335
GO:0031093
GO:0031100
GO:0031410
GO:0031643
GO:0032715
GO:0032733
GO:0033137
GO:0034641
GO:0035729
GO:0040011
GO:0042056
GO:0042802
GO:0043066
GO:0043154
GO:0043226
GO:0044281
GO:0044877
GO:0045669
GO:0045766
GO:0045944
GO:0048012
GO:0048646
GO:0048856
GO:0048870
GO:0050673
GO:0050728
GO:0050731
GO:0050877
GO:0050918
GO:0051450
GO:0051897
GO:0060326
GO:0060665
GO:0070572
GO:0090201
GO:1900744
GO:1901299
GO:1902042
GO:1902947
GO:2000573
Hs.809.0.S3_3p_at
ILMN_1757838
ILMN_1790149
ILMN_1801586
ILMN_1896012
M73239_s_at
PH_hs_0018966
TC07001562.hg
g1378041_3p_at
g184029_3p_a_at
g184029_3p_at
g184031_3p_a_at
Participant Of
input
HGFAC cleaves pro-HGF to form HGF dimer
HPN heterodimer cleaves pro-HGF to form HGF dimer
Other forms of this molecule
HGF(32-494) [platelet alpha granule lumen]
HGF(495-728) [platelet alpha granule lumen]
HGF(495-728) [extracellular region]
HGF(32-494) [extracellular region]
Inferred To
hgfa [extracellular region] (Danio rerio)
asl [extracellular region] (Xenopus tropicalis)
Hgf [extracellular region] (Mus musculus)
Hgf [extracellular region] (Rattus norvegicus)
pro-HGF [extracellular region] (Gallus gallus)
HGF [extracellular region] (Canis familiaris)
HGF [extracellular region] (Sus scrofa)
Cross References
RefSeq
NP_000592.3
,
XP_016867587.1
,
NP_001010932.1
,
NP_001010934.1
,
XP_016867586.1
,
XP_011514417.1
,
XP_006716019.1
,
NP_001010931.1
,
NP_001010933.1
OpenTargets
ENSG00000019991
ZINC - Substances
HGF_HUMAN
GeneCards
P14210
HPA
ENSG00000019991-HGF
Ensembl
ENST00000423064
,
ENSP00000222390
,
ENST00000222390
,
ENSP00000389854
,
ENSP00000391238
,
ENSG00000019991
,
ENSP00000408270
,
ENST00000457544
,
ENST00000444829
,
ENST00000453411
,
ENSP00000413829
ZINC target
P14210
PRO
P14210
Orphanet
18471
ZINC - Predictions - Purchasable
HGF_HUMAN
PDB
1GMO
,
1NK1
,
4O3U
,
3HMS
,
5CS9
,
5CT3
,
5CS5
,
2HGF
,
3HMT
,
4O3T
,
4D3C
,
1BHT
,
1SI5
,
5CP9
,
1SHY
,
1GP9
,
2QJ2
,
5CSQ
,
3MKP
,
3HN4
,
5COE
,
5CS3
,
3SP8
,
5CT2
,
5CT1
,
1GMN
,
4K3J
,
5CS1
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08581 MET
7
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.851
7
UniProt:P14210 HGF
5
HGF(495-728) [platelet alpha granule lumen]
(R-HSA-141764)
HGF(32-494) [platelet alpha granule lumen]
(R-HSA-139866)
pro-HGF [extracellular region]
(R-HSA-6800218)
HGF(495-728) [extracellular region]
(R-HSA-141767)
HGF(32-494) [extracellular region]
(R-HSA-56497)
0.623
2
UniProt:P16056
7
phospho-Met [plasma membrane]
(R-MMU-6807014)
phospho-Met [plasma membrane]
(R-MMU-6807032)
phospho-Met [plasma membrane]
(R-MMU-8874689)
phospho-Met [plasma membrane]
(R-MMU-8875181)
phospho-Met [plasma membrane]
(R-MMU-8875180)
Met [plasma membrane]
(R-MMU-419603)
phospho-Met [plasma membrane]
(R-MMU-6806973)
0.558
2
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:P50222 MEOX2
0.556
3
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