Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
pro-HGF [extracellular region]
Stable Identifier
R-HSA-6800218
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
HGF(32-728), Hepatocyte growth factor alpha chain, Scatter factor, SF, Hepatopoeitin A
Locations in the PathwayBrowser for interactor UniProt:P08581
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by MET (Homo sapiens)
MET Receptor Activation (Homo sapiens)
HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
pro-HGF [extracellular region] (Homo sapiens)
HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
pro-HGF [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14210 HGF
Gene Names
HGF, HPTA
Chain
signal peptide:1-31, chain:32-494, chain:495-728
Reference Genes
BioGPS Gene:3082 HGF
COSMIC (genes):HGF HGF
CTD Gene:3082 HGF
dbSNP Gene:3082 HGF
ENSEMBL:ENSG00000019991 HGF
ENSEMBL_homo_sapiens_GENE:ENSG00000019991.18 HGF
HGNC:4893 HGF
KEGG Gene (Homo sapiens):3082 HGF
Monarch:3082 HGF
NCBI Gene:3082 HGF
OMIM:142409 HGF
UCSC:P14210 HGF
Reference Transcript
RefSeq:NM_001010932.2 HGF
RefSeq:XM_017012097.1 HGF
RefSeq:NM_001010934.2 HGF
RefSeq:NM_001010931.2 HGF
RefSeq:XM_011516115.2 HGF
RefSeq:NM_001010933.2 HGF
RefSeq:XM_017012098.1 HGF
RefSeq:XM_006715956.2 HGF
RefSeq:NM_000601.5 HGF
Other Identifiers
1095_s_at
11730068_a_at
11732351_at
11732746_a_at
11732747_at
1340_s_at
17059165
209960_PM_at
209960_at
209961_PM_s_at
209961_s_at
210755_PM_at
210755_at
210997_3p_at
210997_PM_at
210997_at
210998_PM_s_at
210998_s_at
3058945
3058946
3058947
3058954
3058955
3058956
3058957
3058958
3058959
3058960
3058961
3058963
3058965
3058967
3058968
3058972
3058973
3058974
3058979
3058981
3058982
3058984
3058988
3058989
3082
8140556
A_23_P93780
A_23_P93787
A_24_P944788
A_33_P3276713
A_33_P3276718
GE62425
GO:0000278
GO:0000902
GO:0001837
GO:0001889
GO:0001934
GO:0003824
GO:0004252
GO:0005102
GO:0005515
GO:0005576
GO:0005615
GO:0006351
GO:0006355
GO:0006508
GO:0006914
GO:0006954
GO:0007005
GO:0008083
GO:0010507
GO:0012501
GO:0014856
GO:0016020
GO:0016787
GO:0023052
GO:0030154
GO:0030335
GO:0031093
GO:0031410
GO:0032715
GO:0032733
GO:0033137
GO:0035729
GO:0036211
GO:0042056
GO:0042802
GO:0043066
GO:0043226
GO:0043410
GO:0045669
GO:0045944
GO:0048012
GO:0048018
GO:0048856
GO:0048870
GO:0050673
GO:0050728
GO:0050731
GO:0050918
GO:0051450
GO:0051897
GO:0060326
GO:0060665
GO:0090201
GO:0098772
GO:0140096
GO:1900744
GO:1901299
GO:1902042
GO:2000573
HMNXSV003042284
HMNXSV003051024
HMNXSV003051887
Hs.809.0.S3_3p_at
ILMN_1757838
ILMN_1790149
ILMN_1801586
ILMN_1896012
M73239_s_at
PH_hs_0018966
TC07001562.hg
g1378041_3p_at
g184029_3p_a_at
g184029_3p_at
g184031_3p_a_at
Participates
as an input of
HPN heterodimer cleaves pro-HGF to form HGF dimer (Homo sapiens)
HGFAC cleaves pro-HGF to form HGF dimer (Homo sapiens)
Other forms of this molecule
HGF(32-494) [platelet alpha granule lumen]
HGF(495-728) [platelet alpha granule lumen]
HGF(495-728) [extracellular region]
HGF(32-494) [extracellular region]
Inferred To
Hgf [extracellular region]
(Mus musculus)
Hgf [extracellular region]
(Rattus norvegicus)
pro-HGF [extracellular region]
(Caenorhabditis elegans)
pro-HGF [extracellular region]
(Gallus gallus)
HGF [extracellular region]
(Bos taurus)
HGF [extracellular region]
(Canis familiaris)
HGF [extracellular region]
(Sus scrofa)
hgf [extracellular region]
(Xenopus tropicalis)
Cross References
RefSeq
XP_016867587.1
,
NP_001010933.1
,
XP_006716019.1
,
NP_001010931.1
,
NP_001010934.1
,
XP_016867586.1
,
XP_011514417.1
,
NP_000592.3
,
NP_001010932.1
OpenTargets
ENSG00000019991
ZINC - Substances
HGF_HUMAN
GeneCards
P14210
HPA
ENSG00000019991-HGF
ZINC target
P14210
Ensembl
ENSP00000408270
,
ENSP00000413829
,
ENST00000444829
,
ENST00000457544
,
ENST00000222390
,
ENSP00000222390
,
ENST00000423064
,
ENSP00000391238
,
ENSP00000389854
,
ENSG00000019991
,
ENST00000453411
PRO
P14210
Pharos - Targets
P14210
ZINC - Predictions - Purchasable
HGF_HUMAN
Orphanet
18471
PDB
5CSQ
,
5CT1
,
7OCL
,
7MO7
,
5CS3
,
5CT2
,
3MKP
,
7MO8
,
3HMS
,
7MOB
,
2HGF
,
4K3J
,
3SP8
,
5CP9
,
5CS5
,
1GMN
,
5CS9
,
7MOA
,
1NK1
,
3HMT
,
1BHT
,
1GMO
,
4O3U
,
5CT3
,
2QJ2
,
1SHY
,
4D3C
,
7OCM
,
7MO9
,
5CS1
,
5COE
,
4O3T
,
1GP9
,
3HN4
,
1SI5
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08581 MET
7
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.851
7
UniProt:P14210 HGF
5
HGF(32-494) [platelet alpha granule lumen]
(R-HSA-139866)
HGF(495-728) [platelet alpha granule lumen]
(R-HSA-141764)
pro-HGF [extracellular region]
(R-HSA-6800218)
HGF(495-728) [extracellular region]
(R-HSA-141767)
HGF(32-494) [extracellular region]
(R-HSA-56497)
0.623
2
UniProt:P16056
7
phospho-MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-MMU-8875181)
phospho-MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-MMU-8875180)
phospho-p-Y1003,4Y-MET [plasma membrane]
(R-MMU-8874689)
phospho-p-Y1349,Y1356-MET [plasma membrane]
(R-MMU-6807032)
phospho-p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-MMU-6807014)
MET [plasma membrane]
(R-MMU-419603)
phospho-p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-MMU-6806973)
0.558
2
UniProt:Q6UY14-3 ADAMTSL4
0.556
3
UniProt:P50222 MEOX2
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text