TP53 stimulates BCL6 expression

Stable Identifier
R-HSA-6800250
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Reaction [omitted]
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Homo sapiens
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Binding of TP53 (p53) to the p53 response element in the first intron of the BCL6 gene promotes BCL6 transcription (Margalit et al. 2006). BCL6 is a transcriptional repressor that has been implicated as a facilitator of apoptosis, through inhibition of BCL2 expression (Saito et al. 2009), but also as an inhibitor of apoptosis, through inhibition of TP53 expression (Phan and Dalla-Favera 2004).

Literature References
PubMed ID Title Journal Year
15577913 The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells

Phan, RT, Dalla-Favera, R

Nature 2004
19549844 BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

Saito, M, Novak, U, Piovan, E, Basso, K, Sumazin, P, Schneider, C, Crespo, M, Shen, Q, Bhagat, G, Califano, A, Chadburn, A, Pasqualucci, L, Dalla-Favera, R

Proc. Natl. Acad. Sci. U.S.A. 2009
16249378 BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma

Margalit, O, Amram, H, Amariglio, N, Simon, AJ, Shaklai, S, Granot, G, Minsky, N, Shimoni, A, Harmelin, A, Givol, D, Shohat, M, Oren, M, Rechavi, G

Blood 2006
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