Reactome | HGF dimer binds MET

HGF dimer binds MET

Stable Identifier

R-HSA-6800298

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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Hepatocyte growth factor (HGF) is a pleiotropic factor and activates hepatocyte growth factor receptor (MET). HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage to form the biologically active alpha-beta heterodimer. HGF/MET signalling plays an important role in normal development and in tumor growth and metastasis (Rong et al. 1994, Schmidt et al. 1995, Uehara et al. 1995, Bladt et al. 1995, Schmidt et al. 1997, Pennacchietti et al. 2003, Stamos et al. 2004). HGF binds the SEMA and PSI domain of the MET receptor (Kirchhofer et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9140397	Germline and somatic mutations in the tyrosine kinase domain of the MET proto-oncogene in papillary renal carcinomas Schmidt, L, Bernues, M, Slife, L, Chen, F, Stackhouse, T, Brauch, H, Dean, M, Zbar, B, Casadevall, C, Linehan, WM, Allikmets, R, Orcutt, ML, Zamarron, A, Zhuang, Z, Kishida, T, Richard, S, Niehans, G, Lipan, J, Chidambaram, A, Geil, L, Feltis, JT, Choyke, P, Bergerheim, UR, Duh, FM, Storkel, S, Tsui, LC, Lubensky, I, Lerman, MI, Scherer, SW, Lips, CJ, Glenn, G, Walther, MM, Moch, H, Hughson, MD, Decker, J	Nat. Genet.	1997
8197126	Invasiveness and metastasis of NIH 3T3 cells induced by Met-hepatocyte growth factor/scatter factor autocrine stimulation Segal, S, Rong, S, Resau, JH, Vande Woude, GF, Anver, M	Proc. Natl. Acad. Sci. U.S.A.	1994
12726861	Hypoxia promotes invasive growth by transcriptional activation of the met protooncogene Mazzone, M, Giordano, S, Galluzzo, M, Comoglio, PM, Pennacchietti, S, Michieli, P	Cancer Cell	2003
7651534	Essential role for the c-met receptor in the migration of myogenic precursor cells into the limb bud Birchmeier, C, Riethmacher, D, Bladt, F, Aguzzi, A, Isenmann, S	Nature	1995
15167892	Crystal structure of the HGF beta-chain in complex with the Sema domain of the Met receptor Kirchhofer, D, Wiesmann, C, Stamos, J, Yao, X, Lazarus, RA	EMBO J.	2004
7854452	Scatter factor/hepatocyte growth factor is essential for liver development Brinkmann, V, Zschiesche, W, Sharpe, M, Birchmeier, C, Gherardi, E, Bladt, F, Schmidt, C, Goedecke, S	Nature	1995
7854453	Placental defect and embryonic lethality in mice lacking hepatocyte growth factor/scatter factor Mori, C, Kitamura, N, Noda, T, Kuno, J, Minowa, O, Uehara, Y, Shiota, K	Nature	1995
15218027	Structural and functional basis of the serine protease-like hepatocyte growth factor beta-chain in Met binding and signaling Kirchhofer, D, Billeci, KL, Lipari, MT, Wiesmann, C, Yao, X, Santell, L, Maun, HR, Eigenbrot, C, Peek, M, Lazarus, RA, Moran, P	J. Biol. Chem.	2004