HGFAC cleaves pro-HGF to form HGF dimer

Stable Identifier
R-HSA-6800299
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
HGF is a pleiotropic factor and activates hepatocyte growth factor receptor (MET), a proto-oncogenic receptor tyrosine kinase. HGF is secreted into the extracellular matrix as an inactive single chain precursor (pro-HGF (32-728)) and requires cleavage at Arg494–Val495 to form the biologically active alpha-beta heterodimer. Hepatocyte growth factor activator (HGFAC, commonly known as HGFA) is a serine protease that converts HGF into its active form (Shia et al. 2005). The Kunitz-type protease inhibitor 1 (SPINT1, aka HAI1) is an inhibitor of HGFAC activity (Shia et al. 2005).
Literature References
PubMed ID Title Journal Year
15713485 Conformational lability in serine protease active sites: structures of hepatocyte growth factor activator (HGFA) alone and with the inhibitory domain from HGFA inhibitor-1B

Kirchhofer, D, Shia, S, Corpuz, RT, Stamos, J, Santell, L, Fan, B, Eigenbrot, C, Wu, J, Lazarus, RA

J. Mol. Biol. 2005
Participants
Participates
Catalyst Activity

serine-type endopeptidase activity of HGFAC dimer [extracellular region]

This event is regulated
Orthologous Events
Authored
Reviewed
Created
Cite Us!