Reactome | PSMD12 [ficolin-1-rich granule lumen]

PSMD12 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6800416

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 12, 26S proteasome regulatory subunit p55

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O00232 PSMD12

Gene Names

PSMD12

Chain

initiator methionine:, chain:2-456

Reference Genes

BioGPS Gene:5718 PSMD12

COSMIC (genes):PSMD12 PSMD12

CTD Gene:5718 PSMD12

dbSNP Gene:5718 PSMD12

ENSEMBL:ENSG00000197170 PSMD12

HGNC:9557 PSMD12

KEGG:hsa:5718 PSMD12

Monarch:5718 PSMD12

NCBI Gene:5718 PSMD12

OMIM:604450 PSMD12

UCSC:O00232 PSMD12

Reference Transcript

Other Identifiers

11732779_a_at

11739251_a_at

11758041_s_at

11759291_s_at

1192_at

16848032

202352_PM_s_at

202352_s_at

202353_PM_s_at

202353_s_at

2682615

2682617

2682620

3768104

3768105

3768106

3768107

3768108

3768109

3768110

3768111

3768112

3768113

3768114

3768115

3768117

3768118

3768119

3768120

3768121

3768122

3768123

3768125

3768126

3768127

3768128

3768131

3768132

3768136

3768137

3768138

5718

8017810

AB003103_at

A_23_P112613

A_23_P77876

A_32_P12639

GE53110

GO:0000502

GO:0005515

GO:0005576

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0008541

GO:0016020

GO:0022624

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0070062

GO:1904813

HMNXSV003048354

Hs.4295.0.S1_3p_a_at

ILMN_1670893

ILMN_1684383

ILMN_1691428

ILMN_1767518

ILMN_2368971

PH_hs_0000479

TC17001813.hg

g4506220_3p_a_at

Participates

as a member of

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD12 [cytosol]

PSMD12 [nucleoplasm]

PSMD12 [secretory granule lumen]

PSMD12 [extracellular region]

Inferred To

rpn502 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

rpn-5 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

rpn501 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

PSMD12 [ficolin-1-rich granule lumen] (Bos taurus)

PSMD12 [ficolin-1-rich granule lumen] (Canis familiaris)

PSMD12 [ficolin-1-rich granule lumen] (Gallus gallus)

PSMD12 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

PSMD12 [ficolin-1-rich granule lumen] (Sus scrofa)

psmd12 [ficolin-1-rich granule lumen] (Danio rerio)

psmd12 [ficolin-1-rich granule lumen] (Xenopus tropicalis)

RPN5 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

Rpn5 [ficolin-1-rich granule lumen] (Drosophila melanogaster)

Psmd12 [ficolin-1-rich granule lumen] (Mus musculus)

Psmd12 [ficolin-1-rich granule lumen] (Rattus norvegicus)

Homologues of PSMD12 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

psmD12 [ficolin-1-rich granule lumen] (Dictyostelium discoideum)

Cross References

RefSeq

NP_777360.1, NP_002807.1, NP_001303270.1

OpenTargets

ENSG00000197170

ENSEMBL

ENST00000356126, ENSP00000349667, ENST00000357146, ENSP00000348442

HPA

ENSG00000197170-PSMD12

PRO

O00232

Pharos - Targets

O00232

GlyGen

O00232

Orphanet

PSMD12

PDB

5VHH, 7QYB, 6MSD, 7W3F, 7QXX, 7QY7, 7W3C, 5VGZ, 7W39, 5GJR, 5VHS, 7W3J, 7W3H, 7W3B, 5T0J, 5VHF, 6MSB, 5M32, 7W3A, 5T0G, 6MSJ, 5VFU, 5LN3, 5VFR, 5VFT, 7QXN, 7QXP, 5VHI, 7QYA, 5GJQ, 6MSE, 8CVT, 7W3K, 7W3M, 7W3I, 5T0C, 6MSH, 7W37, 6WJN, 6MSG, 5L4K, 7QXW, 5T0I, 7QXU, 7W3G, 5VFP, 7W38, 5T0H, 6MSK, 5VFQ, 5VFS, 6WJD

Interactors (35)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.804	7
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.802	6
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419)	0.788	6
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.788	7
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.744	5
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [secretory granule lumen] (R-HSA-6801036) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440)	0.744	6
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [secretory granule lumen] (R-HSA-6800943) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436)	0.731	6
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.725	5
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [secretory granule lumen] (R-HSA-6801008) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406)	0.725	5
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.669	3
UniProt:Q9UNM6 PSMD13	5	PSMD13 [cytosol] (R-HSA-68794) PSMD13 [nucleoplasm] (R-HSA-174326) PSMD13 [secretory granule lumen] (R-HSA-6800983) PSMD13 [extracellular region] (R-HSA-6806469) PSMD13 [ficolin-1-rich granule lumen] (R-HSA-6800413)	0.669	5
UniProt:P60228 EIF3E	1	EIF3E [cytosol] (R-HSA-72552)	0.669	4
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [secretory granule lumen] (R-HSA-6800919) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435)	0.643	5
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.643	4
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [secretory granule lumen] (R-HSA-6800873) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408)	0.643	5
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.643	4
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [secretory granule lumen] (R-HSA-6800994) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421)	0.643	5
UniProt:Q7L2H7 EIF3M	1	EIF3M [cytosol] (R-HSA-377448)	0.643	3
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.643	5
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429)	0.643	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	15
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.527	3
UniProt:P25787 PSMA2	5	PSMA2 [cytosol] (R-HSA-68726) PSMA2 [nucleoplasm] (R-HSA-174345) PSMA2 [secretory granule lumen] (R-HSA-6803329) PSMA2 [extracellular region] (R-HSA-6806506) PSMA2 [ficolin-1-rich granule lumen] (R-HSA-6803285)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:P54578 USP14	1	USP14 [cytosol] (R-HSA-5689541)	0.527	2
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	3
UniProt:P28065 PSMB9	3	pro-PSMB9 [cytosol] (R-HSA-9908136) PSMB9 [cytosol] (R-HSA-68765) PSMB9(1-20) [cytosol] (R-HSA-9908132)	0.527	4
UniProt:O00233 PSMD9	1	PSMD9 [cytosol] (R-HSA-68810)	0.527	2
UniProt:Q99460 PSMD1	4	PSMD1 [extracellular region] (R-HSA-6806194) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [cytosol] (R-HSA-68786)	0.527	3
UniProt:Q53HC0 CCD92			0.527	3
UniProt:P43686 PSMC4	2	PSMC4 [nucleoplasm] (R-HSA-174315) PSMC4 [cytosol] (R-HSA-68777)	0.527	4
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:O15372 EIF3H	1	EIF3H [cytosol] (R-HSA-72544)	0.527	2
UniProt:Q99613 EIF3C	1	EIF3C [cytosol] (R-HSA-72550)	0.527	2

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