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Exocytosis of ficolin-rich granule lumen proteins

Stable Identifier
R-HSA-6800434
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Ficoli-1 rich granules are a relatively new fourth neutrophil granule population that is enriched in the microbial lectin ficolin-1. Ficolin-1 is present in tertiary granules, but ficolin-1 rich granules can be differentiated by having low levels of gelatinases and an elevated exocytosis propensity (Rorvig et al. 2009, 2013). The importance of these granules may be to provide rapid release of pattern recognition molecules to activate the lectin complement pathway (Rorvig et al. 2009).

Participants
Participant Of
Orthologous Events