Reactome | PSMD3 [secretory granule lumen]

PSMD3 [secretory granule lumen]

Stable Identifier

R-HSA-6800873

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 3, 26S proteasome regulatory subunit S3, Proteasome subunit p58

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:O43242 PSMD3

Gene Names

PSMD3

Chain

chain:1-534

Reference Genes

BioGPS Gene:5709 PSMD3

COSMIC (genes):PSMD3 PSMD3

CTD Gene:5709 PSMD3

dbSNP Gene:5709 PSMD3

ENSEMBL:ENSG00000108344 PSMD3

HGNC:9560 PSMD3

KEGG Gene (Homo sapiens):5709 PSMD3

Monarch:5709 PSMD3

NCBI Gene:5709 PSMD3

OMIM:617676 PSMD3

UCSC:O43242 PSMD3

Reference Transcript

RefSeq:NM_002809.3 PSMD3

Other Identifiers

0003130746

11715515_a_at

11715516_x_at

11749048_a_at

16833934

201388_at

3720637

3720638

3720639

3720640

3720646

3720647

3720649

3720650

3720651

3720653

3720659

3720660

3720662

3720663

3720665

3720670

3720672

3720673

3720674

39155_at

5709

8006984

A_23_P26783

A_24_P289726

GE81195

GO:0000165

GO:0000209

GO:0000278

GO:0000502

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005838

GO:0006464

GO:0006511

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008541

GO:0009056

GO:0009058

GO:0010972

GO:0016020

GO:0016192

GO:0016579

GO:0022624

GO:0030154

GO:0030234

GO:0031145

GO:0031146

GO:0031410

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0034774

GO:0038061

GO:0038095

GO:0042176

GO:0043161

GO:0043226

GO:0043312

GO:0043488

GO:0043687

GO:0044281

GO:0048856

GO:0050790

GO:0050852

GO:0055085

GO:0060071

GO:0061418

GO:0070062

GO:0070498

GO:0090090

GO:0090263

GO:1901990

GO:1902036

GO:1904813

HMNXSV003001923

ILMN_1796430

PH_hs_0001007

TC17000485.hg

g4506228_3p_s_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD3 [ficolin-1-rich granule lumen]

PSMD3 [extracellular region]

PSMD3 [nucleoplasm]

PSMD3 [cytosol]

Inferred To

Rpn3 [secretory granule lumen] (Drosophila melanogaster)

rpn-3 [secretory granule lumen] (Caenorhabditis elegans)

Psmd3 [secretory granule lumen] (Mus musculus)

Psmd3 [secretory granule lumen] (Rattus norvegicus)

RPN3 [secretory granule lumen] (Saccharomyces cerevisiae)

psmD3 [secretory granule lumen] (Dictyostelium discoideum)

psmd3 [secretory granule lumen] (Danio rerio)

psmd3 [secretory granule lumen] (Xenopus tropicalis)

rpn3 [secretory granule lumen] (Schizosaccharomyces pombe)

PSMD3 [secretory granule lumen] (Bos taurus)

PSMD3 [secretory granule lumen] (Canis familiaris)

PSMD3 [secretory granule lumen] (Gallus gallus)

PSMD3 [secretory granule lumen] (Plasmodium falciparum)

PSMD3 [secretory granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_002800.2

Target Pathogen

5b354852be737e166372eb3a

OpenTargets

ENSG00000108344

HPA

ENSG00000108344-PSMD3

GeneCards

O43242

Ensembl

ENSG00000108344, ENST00000264639, ENSP00000264639

PRO

O43242

PDB

6MSB, 5VFU, 5GJQ, 5VHF, 5VFT, 5M32, 5T0C, 5LN3, 5VHI, 6MSK, 6MSD, 5T0H, 6WJN, 5VHH, 5GJR, 5T0G, 6MSH, 5VFQ, 6MSG, 5T0J, 6WJD, 5VFP, 5T0I, 6MSJ, 6MSE, 5VFS, 5VGZ, 5VFR, 5VHS, 5L4K

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:O00487 PSMD14	5	PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [secretory granule lumen] (R-HSA-6800926) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [cytosol] (R-HSA-68722)	0.564	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P25963 NFKBIA	10	SUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) PolyUb-NFKBIA [cytosol] (R-HSA-6782960) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) NFKBIA [nucleoplasm] (R-HSA-4656929)	0.556	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3
UniProt:P16885 PLCG2	10	PLCG2 [plasma membrane] (R-HSA-114601) p-PLCG2 [plasma membrane] (R-HSA-114602) p-Y753,Y759,Y1217-PLCG2 [plasma membrane] (R-HSA-984816) PLCG2 [cytosol] (R-HSA-984806) PLCG2 [plasma membrane] (R-HSA-2023875) p-4Y-PLCG2 [plasma membrane] (R-HSA-2685601) p-Y753,Y759-PLCG2 [plasma membrane] (R-HSA-5607640) p-Y753,Y759-PLCG2 [cytosol] (R-HSA-5607631) PLCG2 [cytosol] (R-HSA-1604645) p-Y-PLCG2 [cytosol] (R-HSA-9029105)	0.508	2

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