Reactome | TIMP2 [tertiary granule lumen]

TIMP2 [tertiary granule lumen]

Stable Identifier

R-HSA-6800881

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

tertiary granule lumen

Synonyms

Metalloproteinase inhibitor 2, TIMP2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P16035 TIMP2

Gene Names

TIMP2

Chain

signal peptide:1-26, chain:27-220

Reference Genes

BioGPS Gene:7077 TIMP2

COSMIC (genes):TIMP2 TIMP2

CTD Gene:7077 TIMP2

dbSNP Gene:7077 TIMP2

ENSEMBL:ENSG00000035862 TIMP2

ENSEMBL_homo_sapiens_GENE:ENSG00000035862.13 TIMP2

HGNC:11821 TIMP2

KEGG Gene (Homo sapiens):7077 TIMP2

Monarch:7077 TIMP2

NCBI Gene:7077 TIMP2

OMIM:188825 TIMP2

UCSC:P16035 TIMP2

Reference Transcript

RefSeq:NM_003255.4 TIMP2

Other Identifiers

11722786_s_at

11748126_a_at

1375_s_at

16849556

203167_PM_at

203167_at

224560_PM_at

224560_at

231579_PM_s_at

231579_s_at

34722_at

3772662

3772663

3772664

3772665

3772666

3772668

3772669

3772672

3772675

3772711

49080_at

7077

8018966

A_23_P107401

A_33_P3382177

GE618711

GO:0002020

GO:0004857

GO:0005515

GO:0005576

GO:0005615

GO:0008191

GO:0008270

GO:0009725

GO:0030163

GO:0030312

GO:0030414

GO:0031012

GO:0031410

GO:0034097

GO:0035580

GO:0043226

GO:0046872

GO:0051045

GO:0062023

GO:0098772

GO:0140678

GO:1904724

GO:1904813

GO:1905049

HMNXSV003011037

Hs.6441.0.A1_3p_a_at

Hs.6441.0.A1_3p_x_at

ILMN_1721876

ILMN_1749078

M32304_s_at

PH_hs_0030934

TC17002807.hg

g9257247_3p_at

Participates

as a member of

Tertiary granule lumen proteins [tertiary granule lumen] (Homo sapiens)

Other forms of this molecule

TIMP2 [specific granule lumen]

TIMP2 [ficolin-1-rich granule lumen]

TIMP2 [extracellular region]

Inferred To

TIMP2 [tertiary granule lumen] (Bos taurus)

TIMP2 [tertiary granule lumen] (Caenorhabditis elegans)

TIMP2 [tertiary granule lumen] (Canis familiaris)

TIMP2 [tertiary granule lumen] (Danio rerio)

TIMP2 [tertiary granule lumen] (Drosophila melanogaster)

TIMP2 [tertiary granule lumen] (Gallus gallus)

TIMP2 [tertiary granule lumen] (Mus musculus)

TIMP2 [tertiary granule lumen] (Rattus norvegicus)

TIMP2 [tertiary granule lumen] (Sus scrofa)

TIMP2 [tertiary granule lumen] (Xenopus tropicalis)

Homologues of TIMP2 [tertiary granule lumen] (Caenorhabditis elegans)

Cross References

RefSeq

NP_003246.1

OpenTargets

ENSG00000035862

HPA

ENSG00000035862-TIMP2

GeneCards

P16035

Ensembl

ENSP00000262768, ENSG00000035862, ENST00000262768

PRO

P16035

Pharos - Targets

P16035

PDB

1GXD, 1BR9, 4ILW, 2TMP

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08253 MMP2	5	MMP2(67-109) [extracellular region] (R-HSA-1604371) MMP2(67-660) [extracellular region] (R-HSA-1604345) MMP2(30-66) [extracellular region] (R-HSA-1604347) MMP2(30-660) [extracellular region] (R-HSA-1604364) MMP2(110-660) [extracellular region] (R-HSA-381456)	0.688	3
UniProt:P50281 MMP14	3	MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472)	0.564	4
UniProt:Q9UHD9 UBQLN2	1	UBQLN2 [cytosol] (R-HSA-8866007)	0.556	3
UniProt:O95789 ZMYM6			0.527	2
UniProt:P35625 TIMP3	2	TIMP3 [extracellular region] (R-HSA-1430774) TIMP3 [platelet dense granule lumen] (R-HSA-8848904)	0.527	2
UniProt:P22830 FECH	1	FECH [mitochondrial inner membrane] (R-HSA-189441)	0.499	2

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