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CD59 [tertiary granule membrane]
Stable Identifier
R-HSA-6800885
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
tertiary granule membrane
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
CD59 [tertiary granule membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P13987 CD59
Gene Names
CD59, MIC11, MIN1, MIN2, MIN3, MSK21
Chain
signal peptide:1-25, chain:26-102, propeptide:103-128
Reference Genes
BioGPS Gene:966 CD59
COSMIC (genes):CD59 CD59
CTD Gene:966 CD59
dbSNP Gene:966 CD59
ENSEMBL:ENSG00000085063 CD59
ENSEMBL_homo_sapiens_GENE:ENSG00000085063.18 CD59
HGNC:1689 CD59
KEGG Gene (Homo sapiens):966 CD59
Monarch:966 CD59
NCBI Gene:966 CD59
OMIM:107271 CD59
Reference Transcript
RefSeq:NM_001127225.1 CD59
RefSeq:NM_001127227.1 CD59
RefSeq:NM_203330.2 CD59
RefSeq:NM_001127223.1 CD59
RefSeq:NM_001127226.1 CD59
RefSeq:NM_000611.5 CD59
RefSeq:NM_203329.2 CD59
RefSeq:NM_203331.2 CD59
Other Identifiers
11718100_s_at
11718101_at
11718102_at
11757306_s_at
16737194
16737200
200983_PM_x_at
200983_x_at
200984_PM_s_at
200984_s_at
200985_PM_s_at
200985_s_at
212463_PM_at
212463_at
228748_PM_at
228748_at
3368706
3368708
3368709
3368710
3368711
3368712
3368713
3368714
3368715
3368716
3368717
3368718
3368719
3368720
3368721
3368722
3368723
3368724
3368725
3368726
3368727
3368728
3368729
3368730
3368734
3368737
3368738
3368739
3368740
3368741
3368742
3368743
3368745
3368746
3368747
39170_at
39351_at
62133_at
7947425
966
A_23_P75523
A_24_P141481
A_24_P639441
A_24_P784765
A_33_P3409746
GE56215
GE79480
GE88415
GO:0000139
GO:0001848
GO:0001971
GO:0002376
GO:0005515
GO:0005576
GO:0005615
GO:0005783
GO:0005789
GO:0005794
GO:0005886
GO:0005925
GO:0007166
GO:0007596
GO:0009897
GO:0009986
GO:0012507
GO:0016020
GO:0023052
GO:0030133
GO:0030449
GO:0031410
GO:0031982
GO:0033116
GO:0035579
GO:0042060
GO:0043226
GO:0070062
GO:0070821
GO:0098552
GO:1903659
HMNXSV003026907
HMNXSV003054760
Hs.119663.0.S1_3p_a_at
Hs.119663.0.S2_3p_a_at
Hs.293774.0.A1_3p_at
Hs.99766.0.S1_3p_at
ILMN_1669659
ILMN_1724789
ILMN_2333687
M84349_at
PH_hs_0014290
TC11001540.hg
TC11003112.hg
TC11003113.hg
g10835164_3p_a_at
Participates
as a member of
Tertiary granule membrane proteins [tertiary granule membrane] (Homo sapiens)
Other forms of this molecule
GPI-CD59 [Golgi membrane]
GPI-CD59 [transport vesicle]
GPI-CD59 [endoplasmic reticulum-Golgi intermediate compartment membrane]
GPI-CD59 [ER to Golgi transport vesicle membrane]
GPI-CD59 [endoplasmic reticulum membrane]
CD59 [specific granule membrane]
CD59 [plasma membrane]
Inferred To
CD59 [tertiary granule membrane]
(Bos taurus)
CD59 [tertiary granule membrane]
(Canis familiaris)
CD59 [tertiary granule membrane]
(Gallus gallus)
CD59 [tertiary granule membrane]
(Sus scrofa)
Cd59b [tertiary granule membrane]
(Mus musculus)
Cd59 [tertiary granule membrane]
(Rattus norvegicus)
ly97.3 [tertiary granule membrane]
(Danio rerio)
Cross References
RefSeq
NP_976074.1
,
NP_976076.1
,
NP_001120698.1
,
NP_001120695.1
,
NP_976075.1
,
NP_001120699.1
,
NP_000602.1
,
NP_001120697.1
OpenTargets
ENSG00000085063
GeneCards
P13987
HPA
ENSG00000085063-CD59
Ensembl
ENSP00000432942
,
ENSP00000404822
,
ENST00000527577
,
ENSP00000379191
,
ENSP00000498448
,
ENSP00000494884
,
ENSP00000340210
,
ENST00000437761
,
ENST00000415002
,
ENST00000642928
,
ENSP00000410182
,
ENSG00000085063
,
ENST00000351554
,
ENSP00000498879
,
ENST00000445143
,
ENST00000651785
,
ENSP00000403511
,
ENST00000395850
,
ENST00000652678
PRO
P13987
Pharos - Targets
P13987
Orphanet
18955
PDB
8B0G
,
5IMT
,
2J8B
,
8B0H
,
6ZD0
,
1CDR
,
1ERG
,
8B0F
,
1CDQ
,
2UX2
,
2OFS
,
1ERH
,
5IMY
,
4BIK
,
2UWR
,
1CDS
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
10
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.643
9
UniProt:Q15363 TMED2
5
TMED2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-1911531)
TMED2 [endoplasmic reticulum membrane]
(R-HSA-5689480)
TMED2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689847)
TMED2 [transport vesicle]
(R-HSA-6808806)
TMED2 [Golgi membrane]
(R-HSA-6808804)
0.576
4
UniProt:O35587 TMEDA
0.576
5
UniProt:Q5JX71 F209A
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:Q778I9 Q778I9
0.537
4
UniProt:Q01415 GALK2
0.527
2
UniProt:Q86T26 TM11B
0.527
2
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