Reactome | PSMC3 [secretory granule lumen]

PSMC3 [secretory granule lumen]

Stable Identifier

R-HSA-6800917

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

26S protease regulatory subunit 6A, TAT-binding protein 1, TBP-1, Proteasome subunit P50

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P17980 PSMC3

Gene Names

PSMC3, TBP1

Chain

chain:1-439

Reference Genes

BioGPS Gene:5702 PSMC3

COSMIC (genes):PSMC3 PSMC3

CTD Gene:5702 PSMC3

dbSNP Gene:5702 PSMC3

ENSEMBL:ENSG00000165916 PSMC3

HGNC:9549 PSMC3

KEGG Gene (Homo sapiens):5702 PSMC3

Monarch:5702 PSMC3

NCBI Gene:5702 PSMC3

OMIM:186852 PSMC3

UCSC:P17980 PSMC3

Reference Transcript

RefSeq:NM_002804.4 PSMC3

Other Identifiers

0006290136

11715815_a_at

16738023

201267_s_at

3164161

3164167

3164172

3164173

3372212

3372213

3372215

3372216

3372217

3372218

3372219

3372220

3372221

3372222

3372223

3372224

3372225

3372226

3372227

3372229

3372230

5702

592_at

7947867

A_23_P104607

GE61288

GO:0000165

GO:0000166

GO:0000209

GO:0000278

GO:0000502

GO:0000932

GO:0001824

GO:0002223

GO:0002376

GO:0002479

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006464

GO:0006520

GO:0006521

GO:0006810

GO:0006950

GO:0007049

GO:0007165

GO:0007267

GO:0008150

GO:0008540

GO:0009056

GO:0009058

GO:0009790

GO:0010972

GO:0016020

GO:0016032

GO:0016192

GO:0016579

GO:0016787

GO:0016887

GO:0022607

GO:0022624

GO:0030154

GO:0030163

GO:0031145

GO:0031146

GO:0031410

GO:0032991

GO:0033209

GO:0034641

GO:0034655

GO:0034774

GO:0038061

GO:0038095

GO:0042802

GO:0043161

GO:0043167

GO:0043226

GO:0043312

GO:0043488

GO:0043687

GO:0043921

GO:0044281

GO:0044403

GO:0045899

GO:0045944

GO:0048856

GO:0050852

GO:0055085

GO:0060071

GO:0061418

GO:0065003

GO:0070498

GO:0090090

GO:0090263

GO:1901990

GO:1902036

GO:1904813

Hs.250758.0.S1_3p_s_at

ILMN_1809010

M34079_at

PH_hs_0028031

TC11001738.hg

Participant Of

hasMember

Secretory granule lumen proteins [secretory granule lumen]

Other forms of this molecule

PSMC3 [ficolin-1-rich granule lumen]

PSMC3 [extracellular region]

PSMC3 [nucleoplasm]

PSMC3 [cytosol]

Inferred To

Psmc3 [secretory granule lumen] (Mus musculus)

Psmc3 [secretory granule lumen] (Rattus norvegicus)

RPT5 [secretory granule lumen] (Saccharomyces cerevisiae)

Rpt5 [secretory granule lumen] (Drosophila melanogaster)

psmc3 [secretory granule lumen] (Danio rerio)

psmc3 [secretory granule lumen] (Xenopus tropicalis)

psmC3 [secretory granule lumen] (Dictyostelium discoideum)

rpt-5 [secretory granule lumen] (Caenorhabditis elegans)

PSMC3 [secretory granule lumen] (Bos taurus)

PSMC3 [secretory granule lumen] (Canis familiaris)

PSMC3 [secretory granule lumen] (Gallus gallus)

PSMC3 [secretory granule lumen] (Plasmodium falciparum)

PSMC3 [secretory granule lumen] (Sus scrofa)

tbp1 [secretory granule lumen] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_002795.2

Target Pathogen

5b354852be737e166372eb57

OpenTargets

ENSG00000165916

GeneCards

P17980

HPA

ENSG00000165916-PSMC3

Ensembl

ENST00000619920, ENSP00000481029, ENSG00000165916, ENST00000298852, ENSP00000298852

PRO

P17980

PDB

5T0H, 5VHH, 5VFU, 5T0G, 6MSB, 6MSD, 5VHQ, 5VFP, 5VHJ, 6MSE, 5VHR, 5L4G, 5T0I, 5VHI, 5VFQ, 5T0J, 6MSH, 5VHM, 5VHS, 5T0C, 5VFS, 5M32, 6MSG, 5VHN, 5VGZ, 5LN3, 5VFR, 5GJQ, 5GJR, 5VFT, 6MSK, 5VHP, 5VHF, 5VHO, 6MSJ

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [nucleoplasm] (R-HSA-5689584) UCHL5 [cytosol] (R-HSA-1629778)	0.669	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	6
UniProt:O14561 NDUFAB1	3	PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8933545) NDUFAB1 [mitochondrial inner membrane] (R-HSA-163925) Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane] (R-HSA-8934586)	0.556	6
UniProt:P37840 SNCA	4	SNCA [extracellular region] (R-HSA-976954) SNCA A30P [cytosol] (R-HSA-5658569) SNCA [cytosol] (R-HSA-5658500) Ub-SNCA [cytosol] (R-HSA-5660754)	0.556	6
UniProt:P00441 SOD1	5	2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [extracellular region] (R-HSA-350705) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) SOD1 [cytosol] (R-HSA-350697) 2xHC-SOD1 [cytosol] (R-HSA-3299726)	0.556	3
UniProt:P05067 APP	20	APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.547	2
UniProt:Q16186 ADRM1	1	ADRM1 [cytosol] (R-HSA-5665939)	0.527	3

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