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PSMC3 [secretory granule lumen]
Stable Identifier
R-HSA-6800917
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
26S protease regulatory subunit 6A, TAT-binding protein 1, TBP-1, Proteasome subunit P50
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
PSMC3 [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17980 PSMC3
Gene Names
PSMC3, TBP1
Chain
chain:1-439
Reference Genes
BioGPS Gene:5702 PSMC3
COSMIC (genes):PSMC3 PSMC3
CTD Gene:5702 PSMC3
dbSNP Gene:5702 PSMC3
ENSEMBL:ENSG00000165916 PSMC3
HGNC:9549 PSMC3
KEGG Gene (Homo sapiens):5702 PSMC3
Monarch:5702 PSMC3
NCBI Gene:5702 PSMC3
OMIM:186852 PSMC3
UCSC:P17980 PSMC3
Reference Transcript
RefSeq:NM_002804.4 PSMC3
Other Identifiers
0006290136
11715815_a_at
16738023
201267_s_at
3164161
3164167
3164172
3164173
3372212
3372213
3372215
3372216
3372217
3372218
3372219
3372220
3372221
3372222
3372223
3372224
3372225
3372226
3372227
3372229
3372230
5702
592_at
7947867
A_23_P104607
GE61288
GO:0000165
GO:0000166
GO:0000209
GO:0000278
GO:0000502
GO:0000932
GO:0001824
GO:0002223
GO:0002376
GO:0002479
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005576
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006464
GO:0006520
GO:0006521
GO:0006810
GO:0006950
GO:0007049
GO:0007165
GO:0007267
GO:0008150
GO:0008540
GO:0009056
GO:0009058
GO:0009790
GO:0010972
GO:0016020
GO:0016032
GO:0016192
GO:0016579
GO:0016787
GO:0016887
GO:0022607
GO:0022624
GO:0030154
GO:0030163
GO:0031145
GO:0031146
GO:0031410
GO:0032991
GO:0033209
GO:0034641
GO:0034655
GO:0034774
GO:0038061
GO:0038095
GO:0042802
GO:0043161
GO:0043167
GO:0043226
GO:0043312
GO:0043488
GO:0043687
GO:0043921
GO:0044281
GO:0044403
GO:0045899
GO:0045944
GO:0048856
GO:0050852
GO:0055085
GO:0060071
GO:0061418
GO:0065003
GO:0070498
GO:0090090
GO:0090263
GO:1901990
GO:1902036
GO:1904813
Hs.250758.0.S1_3p_s_at
ILMN_1809010
M34079_at
PH_hs_0028031
TC11001738.hg
Participant Of
hasMember
Secretory granule lumen proteins [secretory granule lumen]
Other forms of this molecule
PSMC3 [ficolin-1-rich granule lumen]
PSMC3 [extracellular region]
PSMC3 [nucleoplasm]
PSMC3 [cytosol]
Inferred To
Psmc3 [secretory granule lumen] (Mus musculus)
Psmc3 [secretory granule lumen] (Rattus norvegicus)
RPT5 [secretory granule lumen] (Saccharomyces cerevisiae)
Rpt5 [secretory granule lumen] (Drosophila melanogaster)
psmc3 [secretory granule lumen] (Danio rerio)
psmc3 [secretory granule lumen] (Xenopus tropicalis)
psmC3 [secretory granule lumen] (Dictyostelium discoideum)
rpt-5 [secretory granule lumen] (Caenorhabditis elegans)
PSMC3 [secretory granule lumen] (Bos taurus)
PSMC3 [secretory granule lumen] (Canis familiaris)
PSMC3 [secretory granule lumen] (Gallus gallus)
PSMC3 [secretory granule lumen] (Plasmodium falciparum)
PSMC3 [secretory granule lumen] (Sus scrofa)
tbp1 [secretory granule lumen] (Schizosaccharomyces pombe)
Cross References
RefSeq
NP_002795.2
Target Pathogen
5b354852be737e166372eb57
OpenTargets
ENSG00000165916
GeneCards
P17980
HPA
ENSG00000165916-PSMC3
Ensembl
ENST00000619920
,
ENSP00000481029
,
ENSG00000165916
,
ENST00000298852
,
ENSP00000298852
PRO
P17980
PDB
5T0H
,
5VHH
,
5VFU
,
5T0G
,
6MSB
,
6MSD
,
5VHQ
,
5VFP
,
5VHJ
,
6MSE
,
5VHR
,
5L4G
,
5T0I
,
5VHI
,
5VFQ
,
5T0J
,
6MSH
,
5VHM
,
5VHS
,
5T0C
,
5VFS
,
5M32
,
6MSG
,
5VHN
,
5VGZ
,
5LN3
,
5VFR
,
5GJQ
,
5GJR
,
5VFT
,
6MSK
,
5VHP
,
5VHF
,
5VHO
,
6MSJ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y5K5 UCHL5
2
UCHL5 [nucleoplasm]
(R-HSA-5689584)
UCHL5 [cytosol]
(R-HSA-1629778)
0.669
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
6
UniProt:O14561 NDUFAB1
3
PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8933545)
NDUFAB1 [mitochondrial inner membrane]
(R-HSA-163925)
Mal-PPANT-S112-NDUFAB1 [mitochondrial inner membrane]
(R-HSA-8934586)
0.556
6
UniProt:P37840 SNCA
4
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
SNCA [cytosol]
(R-HSA-5658500)
Ub-SNCA [cytosol]
(R-HSA-5660754)
0.556
6
UniProt:P00441 SOD1
5
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [extracellular region]
(R-HSA-350705)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
0.556
3
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
6
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.547
2
UniProt:Q16186 ADRM1
1
ADRM1 [cytosol]
(R-HSA-5665939)
0.527
3
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