Reactome | CYFIP1 [secretory granule lumen]

CYFIP1 [secretory granule lumen]

Stable Identifier

R-HSA-6800940

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Cytoplasmic FMR1-interacting protein 1, SRA-1, SRA1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7L576 CYFIP1

Gene Names

CYFIP1, KIAA0068

Chain

chain:1-1253

Reference Genes

BioGPS Gene:23191 CYFIP1

COSMIC (genes):CYFIP1 CYFIP1

CTD Gene:23191 CYFIP1

dbSNP Gene:23191 CYFIP1

ENSEMBL:ENSG00000273749 CYFIP1

HGNC:13759 CYFIP1

KEGG:hsa:23191 CYFIP1

Monarch:23191 CYFIP1

NCBI Gene:23191 CYFIP1

OMIM:606322 CYFIP1

UCSC:Q7L576 CYFIP1

Reference Transcript

Other Identifiers

11736683_a_at

11740974_a_at

11759212_at

16797784

208923_PM_at

208923_at

23191

3583637

3583648

3583649

3583650

3583651

3583652

3583654

3583655

3583656

3583657

3583659

3583660

3583662

3583664

3583667

3583672

3583674

3583675

3583676

3583677

3583678

3583679

3583680

3583682

3583683

3583686

3583687

3583688

3583689

3583690

3583691

3583694

3583695

3583696

3583697

3583698

3583699

3583700

3583701

3583704

3583709

3583710

3583711

3583712

3583714

3583715

3583716

3583719

3583720

3583721

3583723

3583724

3583725

3583726

3583727

37306_at

7981824

A_14_P120847

A_23_P140648

D38549_at

GE57193

GO:0000340

GO:0000902

GO:0001726

GO:0003723

GO:0003779

GO:0005515

GO:0005576

GO:0005737

GO:0005829

GO:0005925

GO:0006417

GO:0007399

GO:0007411

GO:0008092

GO:0008360

GO:0010592

GO:0016601

GO:0017148

GO:0030027

GO:0030032

GO:0030154

GO:0030371

GO:0030833

GO:0031175

GO:0031209

GO:0031267

GO:0031529

GO:0031641

GO:0032433

GO:0032869

GO:0034330

GO:0034774

GO:0035580

GO:0043005

GO:0043025

GO:0043195

GO:0043197

GO:0043226

GO:0044294

GO:0044295

GO:0045182

GO:0045202

GO:0045773

GO:0048471

GO:0048675

GO:0048856

GO:0050772

GO:0050877

GO:0050890

GO:0051015

GO:0051388

GO:0051602

GO:0060076

GO:0070062

GO:0090724

GO:0090725

GO:0097484

GO:0098794

GO:0099563

GO:0099578

GO:1900006

GO:1900029

GO:1903422

GO:1904724

GO:1905274

GO:2000601

HMNXSV003009797

HMNXSV003044400

ILMN_1715815

ILMN_1752432

ILMN_2355462

ILMN_2355463

PH_hs_0022067

TC15000028.hg

g13477256_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

CYFIP1 [cytosol]

CYFIP1 [tertiary granule lumen]

CYFIP1 [extracellular region]

CYFIP1 [specific granule lumen]

Inferred To

Cyfip1 [secretory granule lumen] (Mus musculus)

Cyfip1 [secretory granule lumen] (Rattus norvegicus)

CYFIP1 [secretory granule lumen] (Bos taurus)

CYFIP1 [secretory granule lumen] (Canis familiaris)

CYFIP1 [secretory granule lumen] (Gallus gallus)

CYFIP1 [secretory granule lumen] (Sus scrofa)

pirA [secretory granule lumen] (Dictyostelium discoideum)

cyfip1 [secretory granule lumen] (Danio rerio)

gex-2 [secretory granule lumen] (Caenorhabditis elegans)

Cyfip [secretory granule lumen] (Drosophila melanogaster)

Cross References

OpenTargets

ENSG00000273749

ENSEMBL

ENST00000671714, ENSP00000481038, ENSG00000273749, ENSG00000288461, ENSP00000478779, ENST00000617928, ENSP00000480525, ENSP00000500331, ENSP00000499947, ENST00000610365, ENST00000672091, ENST00000617556

HPA

ENSG00000273749-CYFIP1

GeneCards

CYFIP1

PRO

Q7L576

Pharos - Targets

Q7L576

GlyGen

Q7L576

PDB

3P8C, 4N78, 7USD, 7USE, 7USC

HMDB Protein

HMDBP08337

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.643	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P07196 NEFL	1	NEFL [cytosol] (R-HSA-432284)	0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.527	3
UniProt:P63073 Eif4e	1	Eif4e [cytosol] (R-MMU-9817689)	0.525	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7

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