Reactome | KPNB1 [ficolin-1-rich granule lumen]

KPNB1 [ficolin-1-rich granule lumen]

Stable Identifier

R-HSA-6800978

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule lumen

Synonyms

Importin beta-1, Karyopherin beta

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14974 KPNB1

Gene Names

KPNB1, NTF97

Chain

chain:1-876

Reference Genes

BioGPS Gene:3837 KPNB1

COSMIC (genes):KPNB1 KPNB1

CTD Gene:3837 KPNB1

dbSNP Gene:3837 KPNB1

ENSEMBL:ENSG00000108424 KPNB1

HGNC:6400 KPNB1

KEGG Gene (Homo sapiens):3837 KPNB1

Monarch:3837 KPNB1

NCBI Gene:3837 KPNB1

OMIM:602738 KPNB1

UCSC:Q14974 KPNB1

Reference Transcript

Other Identifiers

0004480133

11743115_a_at

11743116_s_at

11744839_a_at

11744840_s_at

11764036_s_at

16835272

208974_x_at

208975_3p_s_at

208975_s_at

213507_3p_s_at

213507_s_at

213573_at

213574_s_at

213803_at

3078596

3535992

3724783

3724784

3724785

3724786

3724787

3724788

3724790

3724793

3724796

3724797

3724798

3724799

3724801

3724803

3724805

3724806

3724807

3724808

3724810

3724811

3724812

3724816

3724817

3724818

3724820

3724821

3724822

3724823

3837

41196_at

47013_at

75097_at

8007992

A_14_P139719

A_23_P118774

A_24_P73920

A_33_P3390441

GE81135

GO:0000278

GO:0002376

GO:0003674

GO:0003723

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005635

GO:0005643

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0006259

GO:0006309

GO:0006606

GO:0006607

GO:0006610

GO:0006629

GO:0006810

GO:0006886

GO:0006913

GO:0007010

GO:0007049

GO:0007059

GO:0007079

GO:0007080

GO:0007165

GO:0008139

GO:0008150

GO:0008219

GO:0008270

GO:0008536

GO:0009056

GO:0009058

GO:0010494

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0019054

GO:0019899

GO:0019904

GO:0022607

GO:0030953

GO:0031291

GO:0031410

GO:0031965

GO:0032991

GO:0034641

GO:0034655

GO:0035580

GO:0040001

GO:0043167

GO:0043226

GO:0043312

GO:0043657

GO:0044281

GO:0044403

GO:0045184

GO:0045540

GO:0051276

GO:0051879

GO:0061608

GO:0061676

GO:0070062

GO:0071782

GO:0075733

GO:0090307

GO:0140014

GO:1904813

Hs.180446.1.A1_3p_a_at

Hs.180446.1.A1_3p_x_at

Hs.180446.2.A1_3p_a_at

Hs.180446.4.A1_3p_a_at

Hs.180446.4.A1_3p_x_at

ILMN_1703949

L38951_at

PH_hs_0027469

TC17000611.hg

g13097743_3p_s_at

g893287_3p_a_at

g893287_3p_s_at

Participant Of

hasMember

Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen]

Other forms of this molecule

KPNB1 [cytosol]

KPNB1 [nucleoplasm]

KPNB1 [extracellular region]

KPNB1 [specific granule lumen]

Inferred To

KPNB1 [ficolin-1-rich granule lumen] (Bos taurus)

KPNB1 [ficolin-1-rich granule lumen] (Canis familiaris)

KPNB1 [ficolin-1-rich granule lumen] (Gallus gallus)

KPNB1 [ficolin-1-rich granule lumen] (Plasmodium falciparum)

KPNB1 [ficolin-1-rich granule lumen] (Sus scrofa)

kap95 [ficolin-1-rich granule lumen] (Schizosaccharomyces pombe)

kpnb1 [ficolin-1-rich granule lumen] (Danio rerio)

kpnb1 [ficolin-1-rich granule lumen] (Xenopus tropicalis)

Fs(2)Ket [ficolin-1-rich granule lumen] (Drosophila melanogaster)

Kpnb1 [ficolin-1-rich granule lumen] (Mus musculus)

Kpnb1 [ficolin-1-rich granule lumen] (Rattus norvegicus)

KAP95 [ficolin-1-rich granule lumen] (Saccharomyces cerevisiae)

imb-1 [ficolin-1-rich granule lumen] (Caenorhabditis elegans)

Cross References

RefSeq

NP_002256.2, NP_001263382.1

OpenTargets

ENSG00000108424

HPA

ENSG00000108424-KPNB1

GeneCards

Q14974

Ensembl

ENST00000540627, ENST00000535458, ENSP00000290158, ENSG00000108424, ENSP00000438964, ENST00000290158, ENSP00000438253

PRO

Q14974

HMDB Protein

HMDBP08462

PDB

1IBR, 2P8Q, 1QGK, 3W5K, 6N89, 6N88, 1QGR, 1M5N, 2QNA, 1F59, 1O6O, 3LWW, 1O6P, 2Q5D

Interactors (32)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P52292 KPNA2	2	KPNA2 [nucleoplasm] (R-HSA-206045) KPNA2 [cytosol] (R-HSA-205976)	0.921	10
UniProt:O00629 KPNA4	2	KPNA4 [cytosol] (R-HSA-1176066) KPNA4 [nucleoplasm] (R-HSA-1176058)	0.743	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.688	3
UniProt:P03101 VL1			0.623	2
UniProt:P14907	1	NSP1 [nuclear envelope] (R-SCE-157713)	0.623	2
UniProt:P51178 PLCD1	1	PLCD1 [plasma membrane] (R-HSA-2023880)	0.602	4
UniProt:O00505 KPNA3	2	KPNA3 [cytosol] (R-HSA-1176070) KPNA3 [nucleoplasm] (R-HSA-1176061)	0.59	2
UniProt:O60684 IMA7			0.59	2
UniProt:P04620 REV			0.576	3
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.567	14
UniProt:Q9ERU9 Ranbp2	5	Ranbp2 [nuclear envelope] (R-MMU-4551599) Ranbp2 [nuclear envelope] (R-MMU-4551720) Ranbp2 [nuclear envelope] (R-MMU-5228524) Ranbp2 [nuclear envelope] (R-MMU-2993756) Ranbp2 [cytosol] (R-MMU-157703)	0.564	2
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.527	3
UniProt:P62826 RAN	2	RAN [cytosol] (R-HSA-165540) RAN [nucleoplasm] (R-HSA-165528)	0.527	2
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	10
UniProt:Q15398 DLGAP5	1	DLGAP5 [cytosol] (R-HSA-264452)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:Q8K4J6	3	Mrtfa [cytosol] (R-MMU-5665975) Mrtfa [nucleoplasm] (R-MMU-3900216) Mrtfa [nucleoplasm] (R-MMU-3900220)	0.525	2
UniProt:Q16637-3 SMN1			0.524	5
UniProt:P27105 STOM	4	STOM [plasma membrane] (R-HSA-6806258) STOM [specific granule membrane] (R-HSA-6799569) STOM [tertiary granule membrane] (R-HSA-6800960) STOM [azurophil granule membrane] (R-HSA-6800997)	0.508	2
UniProt:P04233 CD74	13	CD74(81-104) [lysosomal membrane] (R-HSA-2130446) CD74(81-104) [lysosomal lumen] (R-HSA-2213220) CD74(1-117) [lysosomal membrane] (R-HSA-2130632) CD74 [ER to Golgi transport vesicle membrane] (R-HSA-2130456) CD74 [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-1181241) CD74 [Golgi membrane] (R-HSA-2214388) CD74 [trans-Golgi network membrane] (R-HSA-2130493) CD74 [transport vesicle membrane] (R-HSA-2130624) CD74 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130522) CD74 [endocytic vesicle membrane] (R-HSA-2130460) CD74(1-176) [lysosomal membrane] (R-HSA-2130602) CD74 [lysosomal membrane] (R-HSA-2130320) CD74 [plasma membrane] (R-HSA-2130666)	0.499	2
UniProt:Q15077 P2RY6	1	P2RY6 [plasma membrane] (R-HSA-417924)	0.499	4
UniProt:Q9WMX2 POLG			0.499	2
UniProt:F5H1C8 F5H1C8			0.499	2
UniProt:Q9Y275 TNFSF13B	1	sBAFF [extracellular region] (R-HSA-5676541)	0.499	2
UniProt:Q9H1C4 UNC93B1	4	UNC93B1 [endoplasmic reticulum membrane] (R-HSA-1678930) UNC93B1 [Golgi membrane] (R-HSA-1679064) UNC93B1 P345fs* [endoplasmic reticulum membrane] (R-HSA-9628866) UNC93B1 G261fs* [endoplasmic reticulum membrane] (R-HSA-9628869)	0.499	2
UniProt:Q99558 MAP3K14	5	MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.499	2
1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate [ChEBI:18348]	6	PI(4,5)P2 [Golgi membrane] (R-ALL-1806165) PI(4,5)P2 [plasma membrane] (R-ALL-179856) PI(4,5)P2 [endoplasmic reticulum membrane] (R-ALL-2023856) PI(4,5)P2 [nucleoplasm] (R-ALL-6810412) PI(4,5)P2 [cytoplasmic vesicle membrane] (R-ALL-8874467) PI(4,5)P2 [early endosome membrane] (R-ALL-8849966)	0.462	2
UniProt:P36873 PPP1CC	1	PPP1CC [cytosol] (R-HSA-163443)	0.462	2
UniProt:P62140 PPP1CB	4	PPP1CB [cytosol] (R-HSA-163405) PPP1CB [nucleoplasm] (R-HSA-62003) PPP1CB P49R [cytosol] (R-HSA-9660547) PPP1CB A56P [cytosol] (R-HSA-9660543)	0.462	2
UniProt:P56180-2 TPTE			0.462	2
1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate [ChEBI:16851]	7	PI(3,5)P2 [plasma membrane] (R-ALL-1806224) PI(3,5)P2 [phagophore assembly site membrane] (R-ALL-5692959) PI(3,5)P2 [Golgi membrane] (R-ALL-1806290) PI(3,5)P2 [early endosome membrane] (R-ALL-1806205) PI(3,5)P2 [late endosome membrane] (R-ALL-1806289) PI(3,5)P2 [endoplasmic reticulum membrane] (R-ALL-6809774) PI(3,5)P2 [lysosomal membrane] (R-ALL-5334668)	0.462	2

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