Reactome | PSMD13 [secretory granule lumen]

PSMD13 [secretory granule lumen]

Stable Identifier

R-HSA-6800983

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

26S proteasome non-ATPase regulatory subunit 13, 26S proteasome regulatory subunit S11, 26S proteasome regulatory subunit p40.5

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9UNM6 PSMD13

Gene Names

PSMD13

Chain

chain:1-376

Reference Genes

BioGPS Gene:5719 PSMD13

COSMIC (genes):PSMD13 PSMD13

CTD Gene:5719 PSMD13

dbSNP Gene:5719 PSMD13

ENSEMBL:ENSG00000185627 PSMD13

HGNC:9558 PSMD13

KEGG:hsa:5719 PSMD13

Monarch:5719 PSMD13

NCBI Gene:5719 PSMD13

OMIM:603481 PSMD13

UCSC:Q9UNM6 PSMD13

Reference Transcript

Other Identifiers

11719927_a_at

11741771_a_at

11756188_x_at

16720006

201232_PM_s_at

201232_s_at

201233_PM_at

201233_at

32211_at

3315550

3315551

3315552

3315554

3315555

3315556

3315557

3315558

3315559

3315560

3315561

3315562

3315563

3315564

3315567

3315568

3315569

3315570

3315571

3315572

3315573

3315574

3315575

3315576

3315577

3315579

50015_at

5719

7937287

A_14_P122117

A_23_P75889

GE797693

GE81196

GO:0000502

GO:0005198

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005829

GO:0005838

GO:0006511

GO:0007127

GO:0008541

GO:0016020

GO:0022414

GO:0022624

GO:0030163

GO:0034774

GO:0043161

GO:0043226

GO:0140013

GO:1904813

HMNXSV003050587

ILMN_1704404

ILMN_2342121

PH_hs_0014359

TC11000006.hg

TC11002481.hg

g4506222_3p_s_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PSMD13 [cytosol]

PSMD13 [nucleoplasm]

PSMD13 [ficolin-1-rich granule lumen]

PSMD13 [extracellular region]

Inferred To

rpn-9 [secretory granule lumen] (Caenorhabditis elegans)

Rpn9 [secretory granule lumen] (Drosophila melanogaster)

psmd13 [secretory granule lumen] (Danio rerio)

psmd13 [secretory granule lumen] (Xenopus tropicalis)

RPN9 [secretory granule lumen] (Saccharomyces cerevisiae)

rpn9 [secretory granule lumen] (Schizosaccharomyces pombe)

psmD13 [secretory granule lumen] (Dictyostelium discoideum)

Psmd13 [secretory granule lumen] (Mus musculus)

Psmd13 [secretory granule lumen] (Rattus norvegicus)

PSMD13 [secretory granule lumen] (Bos taurus)

PSMD13 [secretory granule lumen] (Canis familiaris)

PSMD13 [secretory granule lumen] (Gallus gallus)

PSMD13 [secretory granule lumen] (Plasmodium falciparum)

PSMD13 [secretory granule lumen] (Sus scrofa)

Cross References

RefSeq

NP_787128.2, NP_002808.3

OpenTargets

ENSG00000185627

ENSEMBL

ENSP00000396937, ENSG00000185627, ENSP00000436186, ENST00000532097, ENST00000431206

HPA

ENSG00000185627-PSMD13

GeneCards

PSMD13

PRO

Q9UNM6

Pharos - Targets

Q9UNM6

GlyGen

Q9UNM6

PDB

7W37, 5M32, 6WJN, 7QXW, 6MSG, 5T0G, 7W3M, 7W3K, 5T0J, 7QXP, 7QXN, 6MSE, 8CVT, 5GJQ, 7QYB, 5VHI, 5VHH, 6WJD, 5L4K, 5VFS, 5VFP, 5VFQ, 6MSK, 7W3G, 7QXU, 5LN3, 6MSH, 7W3I, 7W38, 5GJR, 7W39, 5VGZ, 5T0H, 7W3F, 5T0I, 5VHS, 7QXX, 6MSD, 7W3C, 7QY7, 5T0C, 7QYA, 5VFU, 5VFT, 5VHF, 7W3B, 7W3H, 7W3J, 5VFR, 6MSJ, 6MSB, 7W3A

Interactors (29)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55036 PSMD4	1	PSMD4 [cytosol] (R-HSA-68800)	0.758	5
UniProt:P62333 PSMC6	2	PSMC6 [cytosol] (R-HSA-68783) PSMC6 [nucleoplasm] (R-HSA-174319)	0.745	5
UniProt:O00231 PSMD11	5	PSMD11 [cytosol] (R-HSA-68790) PSMD11 [nucleoplasm] (R-HSA-174327) PSMD11 [ficolin-1-rich granule lumen] (R-HSA-6800436) PSMD11 [extracellular region] (R-HSA-6806441) PSMD11 [secretory granule lumen] (R-HSA-6800943)	0.745	6
UniProt:P62191 PSMC1	2	PSMC1 [cytosol] (R-HSA-68768) PSMC1 [nucleoplasm] (R-HSA-174338)	0.744	5
UniProt:Q9Y5K5 UCHL5	2	UCHL5 [cytosol] (R-HSA-1629778) UCHL5 [nucleoplasm] (R-HSA-5689584)	0.725	6
UniProt:P43686 PSMC4	2	PSMC4 [cytosol] (R-HSA-68777) PSMC4 [nucleoplasm] (R-HSA-174315)	0.669	6
UniProt:O43242 PSMD3	5	PSMD3 [cytosol] (R-HSA-68798) PSMD3 [nucleoplasm] (R-HSA-174328) PSMD3 [ficolin-1-rich granule lumen] (R-HSA-6800408) PSMD3 [extracellular region] (R-HSA-6806443) PSMD3 [secretory granule lumen] (R-HSA-6800873)	0.669	5
UniProt:Q15008 PSMD6	5	PSMD6 [cytosol] (R-HSA-68804) PSMD6 [nucleoplasm] (R-HSA-174316) PSMD6 [ficolin-1-rich granule lumen] (R-HSA-6800440) PSMD6 [extracellular region] (R-HSA-6806486) PSMD6 [secretory granule lumen] (R-HSA-6801036)	0.669	6
UniProt:Q13200 PSMD2	5	PSMD2 [cytosol] (R-HSA-68796) PSMD2 [nucleoplasm] (R-HSA-174311) PSMD2 [ficolin-1-rich granule lumen] (R-HSA-6800435) PSMD2 [extracellular region] (R-HSA-6806479) PSMD2 [secretory granule lumen] (R-HSA-6800919)	0.669	5
UniProt:P62195 PSMC5	2	PSMC5 [cytosol] (R-HSA-68780) PSMC5 [nucleoplasm] (R-HSA-174312)	0.669	5
UniProt:Q99460 PSMD1	4	PSMD1 [cytosol] (R-HSA-68786) PSMD1 [nucleoplasm] (R-HSA-174348) PSMD1 [azurophil granule lumen] (R-HSA-6798741) PSMD1 [extracellular region] (R-HSA-6806194)	0.669	4
UniProt:P35998 PSMC2	5	PSMC2 [cytosol] (R-HSA-68771) PSMC2 [nucleoplasm] (R-HSA-174332) PSMC2 [ficolin-1-rich granule lumen] (R-HSA-6800421) PSMC2 [extracellular region] (R-HSA-6806472) PSMC2 [secretory granule lumen] (R-HSA-6800994)	0.669	5
UniProt:O00487 PSMD14	5	PSMD14 [cytosol] (R-HSA-68722) PSMD14 [nucleoplasm] (R-HSA-174329) PSMD14 [ficolin-1-rich granule lumen] (R-HSA-6800419) PSMD14 [extracellular region] (R-HSA-6806511) PSMD14 [secretory granule lumen] (R-HSA-6800926)	0.669	4
UniProt:P17980 PSMC3	5	PSMC3 [cytosol] (R-HSA-68774) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [secretory granule lumen] (R-HSA-6800917)	0.669	4
UniProt:P51665 PSMD7	5	PSMD7 [cytosol] (R-HSA-68806) PSMD7 [nucleoplasm] (R-HSA-174309) PSMD7 [ficolin-1-rich granule lumen] (R-HSA-6800406) PSMD7 [extracellular region] (R-HSA-6806488) PSMD7 [secretory granule lumen] (R-HSA-6801008)	0.669	4
UniProt:O00232 PSMD12	5	PSMD12 [cytosol] (R-HSA-68792) PSMD12 [nucleoplasm] (R-HSA-174339) PSMD12 [ficolin-1-rich granule lumen] (R-HSA-6800416) PSMD12 [extracellular region] (R-HSA-6806480) PSMD12 [secretory granule lumen] (R-HSA-6800934)	0.669	5
UniProt:O75832 PSMD10	1	PSMD10 [cytosol] (R-HSA-68788)	0.643	4
UniProt:Q9Y4K3 TRAF6	8	TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [endosome membrane] (R-HSA-450272) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) K48polyUb-TRAF6 [cytosol] (R-HSA-6783233)	0.589	2
UniProt:P25786 PSMA1	2	PSMA1 [cytosol] (R-HSA-68724) PSMA1 [nucleoplasm] (R-HSA-174333)	0.564	2
UniProt:P60900 PSMA6	2	PSMA6 [cytosol] (R-HSA-68734) PSMA6 [nucleoplasm] (R-HSA-174314)	0.564	2
UniProt:P48556 PSMD8	2	PSMD8 [cytosol] (R-HSA-68808) PSMD8 [nucleoplasm] (R-HSA-174318)	0.564	3
UniProt:O14818 PSMA7	2	PSMA7 [cytosol] (R-HSA-68736) PSMA7 [nucleoplasm] (R-HSA-174351)	0.564	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q9BRP4 PAAF1	1	PAAF1 [cytosol] (R-HSA-9907973)	0.527	2
UniProt:Q16186 ADRM1	2	ADRM1 [cytosol] (R-HSA-5665939) ADRM1 [nucleoplasm] (R-HSA-9918361)	0.527	4
UniProt:Q16401 PSMD5	1	PSMD5 [cytosol] (R-HSA-68802)	0.527	3
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.527	2
UniProt:P49720 PSMB3	2	PSMB3 [cytosol] (R-HSA-68747) PSMB3 [nucleoplasm] (R-HSA-174341)	0.527	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	11

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