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ACLY [ficolin-1-rich granule lumen]
Stable Identifier
R-HSA-6801031
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
ficolin-1-rich granule lumen
Synonyms
citrate lyase monomer, ATP citrate lyase, ATP-citrate synthase , ATP-citrate (pro-S-)-lyase, Citrate cleavage enzyme
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule lumen proteins (Homo sapiens)
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
ACLY [ficolin-1-rich granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53396 ACLY
Gene Names
ACLY
Chain
chain:1-1101
Reference Genes
BioGPS Gene:47 ACLY
COSMIC (genes):ACLY ACLY
CTD Gene:47 ACLY
dbSNP Gene:47 ACLY
ENSEMBL:ENSG00000131473 ACLY
HGNC:115 ACLY
KEGG:hsa:47 ACLY
Monarch:47 ACLY
NCBI Gene:47 ACLY
OMIM:108728 ACLY
UCSC:P53396 ACLY
Reference Transcript
RefSeq:NM_001303274.1 ACLY
RefSeq:XM_005257395.1 ACLY
RefSeq:XM_017024688.1 ACLY
RefSeq:NM_001096.2 ACLY
RefSeq:NM_001303275.1 ACLY
RefSeq:NM_198830.1 ACLY
Other Identifiers
11720620_s_at
11720621_s_at
16844936
201127_PM_s_at
201127_s_at
201128_PM_s_at
201128_s_at
210337_PM_s_at
210337_s_at
3757434
3757435
3757436
3757437
3757439
3757440
3757441
3757442
3757444
3757445
3757446
3757449
3757450
3757451
3757452
3757454
3757456
3757457
3757458
3757460
3757461
3757462
3757463
3757465
3757468
3757469
3757470
3757471
3757472
3757473
3757474
3757476
3757477
3757478
3757479
3757481
3757482
3757484
40881_at
47
8015460
A_33_P3415042
GE59906
GO:0003824
GO:0003878
GO:0005515
GO:0005524
GO:0005576
GO:0005654
GO:0005737
GO:0005829
GO:0006085
GO:0006101
GO:0006107
GO:0006629
GO:0006633
GO:0006695
GO:0006790
GO:0008610
GO:0015936
GO:0016020
GO:0016740
GO:0035578
GO:0043226
GO:0046872
GO:0046912
GO:0055086
GO:0070062
GO:1901135
GO:1904813
HMNXSV003013563
HMNXSV003042360
ILMN_1749014
ILMN_2371379
PH_hs_0028307
TC17001520.hg
X64330_at
g4501864_3p_s_at
g603073_3p_s_at
Participates
as a member of
Ficolin-rich granule lumen proteins [ficolin-1-rich granule lumen] (Homo sapiens)
Other forms of this molecule
ACLY [azurophil granule lumen]
ACLY [extracellular region]
ACLY [cytosol]
Inferred To
Acly [ficolin-1-rich granule lumen]
(Drosophila melanogaster)
aclya [ficolin-1-rich granule lumen]
(Danio rerio)
ACLY [ficolin-1-rich granule lumen]
(Bos taurus)
ACLY [ficolin-1-rich granule lumen]
(Caenorhabditis elegans)
ACLY [ficolin-1-rich granule lumen]
(Canis familiaris)
ACLY [ficolin-1-rich granule lumen]
(Dictyostelium discoideum)
ACLY [ficolin-1-rich granule lumen]
(Gallus gallus)
ACLY [ficolin-1-rich granule lumen]
(Mus musculus)
ACLY [ficolin-1-rich granule lumen]
(Rattus norvegicus)
ACLY [ficolin-1-rich granule lumen]
(Schizosaccharomyces pombe)
ACLY [ficolin-1-rich granule lumen]
(Sus scrofa)
acly [ficolin-1-rich granule lumen]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
3245
OpenTargets
ENSG00000131473
ENSEMBL
ENSP00000466259
,
ENSP00000253792
,
ENSP00000377474
,
ENST00000537919
,
ENSP00000445349
,
ENST00000352035
,
ENST00000393896
,
ENST00000590151
,
ENSP00000345398
,
ENST00000353196
ZINC - Substances
ACLY_HUMAN
ZINC - Biogenic
ACLY_HUMAN
ZINC target
P53396
PRO
P53396
GlyGen
P53396
PDB
7RMP
,
5TDZ
,
3MWD
,
6HXL
,
7RIG
,
6QFB
,
7LIW
,
7LLA
,
3MWE
,
6UI9
,
5TDM
,
5TET
,
8G5D
,
6UUZ
,
6UIA
,
6HXK
,
8G5C
,
5TDE
,
8G1F
,
6UV5
,
5TDF
,
6HXM
,
7RKZ
,
7LJ9
,
5TEQ
,
6O0H
,
6POF
,
6UUW
,
6POE
,
5TE1
,
3PFF
,
5TES
,
6Z2H
,
8G1E
,
6HXH
ZINC - Metabolites
ACLY_HUMAN
HPA
ENSG00000131473-ACLY
Pharos - Targets
P53396
ZINC - Predictions - Purchasable
ACLY_HUMAN
HMDB Protein
HMDBP00010
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
17
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