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CCT8 [secretory granule lumen]
Stable Identifier
R-HSA-6801035
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
T-complex protein 1 subunit theta (TCP-1-theta)
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
CCT8 [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P50990 CCT8
Gene Names
CCT8, C21orf112, CCTQ, KIAA0002
Chain
initiator methionine:, chain:2-548
Reference Genes
BioGPS Gene:10694 CCT8
COSMIC (genes):CCT8 CCT8
CTD Gene:10694 CCT8
dbSNP Gene:10694 CCT8
ENSEMBL:ENSG00000156261 CCT8
HGNC:1623 CCT8
KEGG:hsa:10694 CCT8
Monarch:10694 CCT8
NCBI Gene:10694 CCT8
OMIM:617786 CCT8
UCSC:P50990 CCT8
Reference Transcript
RefSeq:NM_006585.3 CCT8
RefSeq:NM_001282907.1 CCT8
RefSeq:NM_001282909.1 CCT8
Other Identifiers
10694
11733131_s_at
11752550_x_at
11756850_x_at
11757031_a_at
16924719
200873_PM_s_at
200873_s_at
2433265
2433269
2433271
2433273
3928071
3928072
3928073
3928076
3928077
3928078
3928079
3928080
3928081
3928082
3928083
3928084
3928085
3928086
3928087
3928088
3928089
3928090
3928091
3928092
3928093
3928094
3928095
3928097
3928099
3928101
3928102
3928103
3928104
3928105
39767_at
8069753
A_23_P102876
D13627_at
GE57061
GO:0002199
GO:0003824
GO:0005515
GO:0005524
GO:0005576
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005832
GO:0005856
GO:0005874
GO:0005929
GO:0006457
GO:0007339
GO:0016787
GO:0016887
GO:0032212
GO:0034774
GO:0035578
GO:0042995
GO:0043226
GO:0044183
GO:0044297
GO:0045111
GO:0045296
GO:0050821
GO:0051082
GO:0051086
GO:0061077
GO:0070062
GO:0140657
GO:0140662
GO:1904813
GO:1904871
GO:1904874
HMNXSV003027142
HMNXSV003041563
ILMN_1717868
PH_hs_0025044
TC21000353.hg
g13528842_3p_at
g6005726_3p_a_at
Participates
as a member of
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
CCT8 [extracellular region]
CCT8 [azurophil granule lumen]
CCT8 [ficolin-1-rich granule lumen]
CCT8 [cytosol]
Inferred To
CCT8 [secretory granule lumen]
(Bos taurus)
CCT8 [secretory granule lumen]
(Canis familiaris)
CCT8 [secretory granule lumen]
(Drosophila melanogaster)
CCT8 [secretory granule lumen]
(Gallus gallus)
CCT8 [secretory granule lumen]
(Plasmodium falciparum)
CCT8 [secretory granule lumen]
(Saccharomyces cerevisiae)
CCT8 [secretory granule lumen]
(Sus scrofa)
Cct8 [secretory granule lumen]
(Mus musculus)
Cct8 [secretory granule lumen]
(Rattus norvegicus)
cct8 [secretory granule lumen]
(Dictyostelium discoideum)
cct8 [secretory granule lumen]
(Schizosaccharomyces pombe)
cct8 [secretory granule lumen]
(Xenopus tropicalis)
cct-8 [secretory granule lumen]
(Caenorhabditis elegans)
Cross References
OpenTargets
ENSG00000156261
ENSEMBL
ENST00000626972
,
ENST00000707884
,
ENST00000707892
,
ENSP00000286788
,
ENST00000707885
,
ENSP00000486921
,
ENST00000286788
,
ENSP00000517018
,
ENSP00000517017
,
ENSP00000442730
,
ENSP00000517020
,
ENST00000540844
HPA
ENSG00000156261-CCT8
PRO
P50990
Pharos - Targets
P50990
GlyGen
P50990
PDB
8I1U
,
8SFE
,
7WZ3
,
7NVN
,
8I9U
,
8SHT
,
7TRG
,
6NR9
,
7X7Y
,
8SHE
,
7X0A
,
7LUM
,
7TUB
,
8SGQ
,
8SHL
,
8SHD
,
8SG8
,
7X3J
,
7WU7
,
7TTN
,
7X0S
,
6NRA
,
7X0V
,
6NRD
,
6NRC
,
8SHP
,
8SFF
,
7NVO
,
8HKI
,
7NVL
,
6NR8
,
7X3U
,
8SGL
,
7X6Q
,
8SHG
,
8SH9
,
7LUP
,
6QB8
,
8SHF
,
8SHA
,
8SG9
,
8SHO
,
7TTT
,
8SGC
,
7NVM
,
8SHQ
,
8IB8
,
6NRB
,
8SHN
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P67775 PPP2CA
4
PPP2CA [cytosol]
(R-HSA-165971)
PPP2CA [nucleoplasm]
(R-HSA-165978)
p-Y307-PPP2CA [cytosol]
(R-HSA-8857939)
MeL-PPP2CA [nucleoplasm]
(R-HSA-8857791)
0.725
4
UniProt:Q13418 ILK
1
ILK [cytosol]
(R-HSA-432864)
0.725
4
UniProt:P17987 TCP1
1
TCP1 [cytosol]
(R-HSA-390448)
0.669
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
4
UniProt:P04049 RAF1
20
p-S338,Y340,Y341-RAF1 [cytosol]
(R-HSA-5624465)
p-S338-RAF1 [cytosol]
(R-HSA-5624469)
p-S621-RAF1 S259F [cytosol]
(R-HSA-9656124)
p-S621-RAF1 S257L [cytosol]
(R-HSA-9656121)
p-S621-RAF1 P261L [cytosol]
(R-HSA-9656106)
p-S621-RAF1 N262K [cytosol]
(R-HSA-9656101)
p-S621-RAF1 P261A [cytosol]
(R-HSA-9656103)
p-S621-RAF1 P261S [cytosol]
(R-HSA-9656113)
p-S621-RAF1 S259T [cytosol]
(R-HSA-9656130)
p-S621-RAF1 P261T [cytosol]
(R-HSA-9656115)
p-S621-RAF1 P261R [cytosol]
(R-HSA-9656110)
p-S621-RAF1 S259P [cytosol]
(R-HSA-9656127)
p-S621-RAF1 T260I [cytosol]
(R-HSA-9656136)
p-S621-RAF1 T260R [cytosol]
(R-HSA-9656139)
p-S621-RAF1 V263A [cytosol]
(R-HSA-9656148)
p-S621-RAF1 R256S [cytosol]
(R-HSA-9656119)
p-S621-RAF1 T491I [cytosol]
(R-HSA-9656143)
p-S621-RAF1 D486N [cytosol]
(R-HSA-9656088)
p-S621-RAF1 S427G [cytosol]
(R-HSA-9656134)
p-S621-RAF1 L613V [cytosol]
(R-HSA-9656098)
0.643
7
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
CDK5 [nucleoplasm]
(R-HSA-8863586)
0.643
3
UniProt:Q13547 HDAC1
2
HDAC1 [nucleoplasm]
(R-HSA-205021)
monoSUMO1-K444,K476-HDAC1 [nucleoplasm]
(R-HSA-4616030)
0.643
4
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
19
UniProt:O43815 STRN
5
STRN [cytosol]
(R-HSA-9037081)
STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673902)
p-11Y-STRN(1-265)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673908)
STRN(1-137)-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700485)
STRN(1-137)-p-7Y-ALK(1058-1620) fusion [cytosol]
(R-HSA-9700467)
0.527
2
UniProt:O00628 PEX7
2
PEX7 [peroxisomal membrane]
(R-HSA-9033493)
PEX7 [cytosol]
(R-HSA-9033107)
0.527
3
UniProt:Q9BUR4 WRAP53
2
WRAP53 [nucleoplasm]
(R-HSA-418386)
Unfolded WRAP53 [cytosol]
(R-HSA-6813830)
0.527
2
UniProt:P52333 JAK3
6
JAK3 [cytosol]
(R-HSA-451893)
p-Y-JAK3 [cytosol]
(R-HSA-9006854)
p-JAK3 [cytosol]
(R-HSA-8982856)
JAK3 [endosome]
(R-HSA-8983184)
p-Y904,939-JAK3 [plasma membrane]
(R-HSA-8985978)
p-Y980 JAK3 [cytosol]
(R-HSA-9701438)
0.527
2
UniProt:Q13882 PTK6
5
PTK6 [cytosol]
(R-HSA-8848000)
p-Y342-PTK6 [cytosol]
(R-HSA-8848007)
p-Y342-PTK6 [nucleoplasm]
(R-HSA-8848937)
p-Y351-PTK6 [cytosol]
(R-HSA-8857570)
p-Y342,Y447-PTK6 [cytosol]
(R-HSA-8849103)
0.527
3
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