Reactome | TP53 stimulates RABGGTA expression

TP53 stimulates RABGGTA expression

Stable Identifier

R-HSA-6801089

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

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Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - TP53 Regulates Transcription of Cell Death Genes (Homo sapiens)
        
        TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)
        
        TP53 stimulates RABGGTA expression (Homo sapiens)

General

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Binding of TP53 (p53) to the p53 response element in the promoter of the RABGGTA gene promotes RABGGTA transcription (Jen and Cheung 2005).

Literature References

PubMed ID	Title	Journal	Year
16140933	Identification of novel p53 target genes in ionizing radiation response Jen, KY, Cheung, VG	Cancer Res.	2005

Participants

Input

RABGGTA Gene [nucleoplasm] (Homo sapiens)

Output

RABGGTA [plasma membrane] (Homo sapiens)

Participates

as an event of

TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain (Homo sapiens)

This event is regulated

Positively by

Regulator

p-S15,S20-TP53 Tetramer:RABGGTA Gene [nucleoplasm] (Homo sapiens)

Active Unit

p-S15,S20-TP53 Tetramer [nucleoplasm]

Authored

Orlic-Milacic, M (2015-10-14)

Reviewed

Zaccara, S (2016-02-04)

Inga, A (2016-02-04)

Created

Orlic-Milacic, M (2015-09-30)

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