TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane

Stable Identifier
R-HSA-6801250
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The complex of TP53-regulated inhibitor of apoptosis 1 (TRIAP1) and mitochondrial PRELI domain-containing protein 1 PRELID1 (TRIAP1:PRELID1) facilitates transport of phosphatidic acid (PA) from the outer mitochondrial membrane to the inner mitochondrial membrane. At the inner mitochondrial membrane, the PA is used for the synthesis of cardiolipin (CL). CL prevents the release of cytochrome C from mitochondria, thus playing an anti-apoptotic role (Potting et al. 2013). The complex between TRIAP1 and PRELI domain containing protein 3A (PRELID3A) is suggested to perform the same PA transport activity (Miliara et al. 2015)

Literature References
PubMed ID Title Journal Year
23931759 TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid

Potting, C, Tatsuta, T, König, T, Haag, M, Wai, T, Aaltonen, MJ, Langer, T

Cell Metab. 2013
26071602 Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes

Miliara, X, Garnett, JA, Tatsuta, T, Abid Ali, F, Baldie, H, Pérez-Dorado, I, Simpson, P, Yague, E, Langer, T, Matthews, S

EMBO Rep. 2015
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
lipid transporter activity of TRIAP1:PRELID1, PRELID3A [mitochondrial intermembrane space]
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Activity
Orthologous Events
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