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CTSS [tertiary granule lumen]
Stable Identifier
R-HSA-6801308
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
tertiary granule lumen
Synonyms
Cathepsin S, CATS_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of tertiary granule lumen proteins (Homo sapiens)
Tertiary granule lumen proteins [tertiary granule lumen] (Homo sapiens)
CTSS [tertiary granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P25774 CTSS
Gene Names
CTSS
Chain
signal peptide:1-16, propeptide:17-114, chain:115-331
Reference Genes
BioGPS Gene:1520 CTSS
COSMIC (genes):CTSS CTSS
CTD Gene:1520 CTSS
dbSNP Gene:1520 CTSS
ENSEMBL:ENSG00000163131 CTSS
ENSEMBL_homo_sapiens_GENE:ENSG00000163131.12 CTSS
HGNC:2545 CTSS
KEGG Gene (Homo sapiens):1520 CTSS
Monarch:1520 CTSS
NCBI Gene:1520 CTSS
OMIM:116845 CTSS
UCSC:P25774 CTSS
Reference Transcript
RefSeq:NM_004079.4 CTSS
RefSeq:NM_001199739.1 CTSS
Other Identifiers
11719554_at
11749589_x_at
1520
16692834
202901_PM_x_at
202901_x_at
202902_PM_s_at
202902_s_at
232617_PM_at
232617_at
2434576
2434577
2434578
2434579
2434580
2434581
2434582
2434583
2434584
2434589
2434592
2434594
2434595
2434596
2434598
2434599
2434600
41239_r_at
65578_at
7919800
A_23_P46141
A_24_P242646
GE61720
GE86289
GO:0001968
GO:0002224
GO:0002250
GO:0002376
GO:0003824
GO:0004197
GO:0004252
GO:0005518
GO:0005576
GO:0005615
GO:0005764
GO:0005768
GO:0005770
GO:0005773
GO:0006508
GO:0006915
GO:0006955
GO:0008233
GO:0008234
GO:0008656
GO:0010447
GO:0012501
GO:0016485
GO:0016787
GO:0019882
GO:0019886
GO:0022617
GO:0023052
GO:0030163
GO:0030198
GO:0030312
GO:0030574
GO:0031012
GO:0031410
GO:0034769
GO:0036021
GO:0043202
GO:0043226
GO:0043231
GO:0043236
GO:0043394
GO:0045335
GO:0048002
GO:0051603
GO:0051604
GO:0055085
GO:0062023
GO:0097067
GO:0098542
GO:0098772
GO:0140096
GO:1904724
GO:1904813
GO:2001235
GO:2001259
HMNXSV003014522
Hs.181301.1.S1_3p_at
ILMN_1743032
M90696_at
PH_hs_0010728
TC01003210.hg
g12803614_3p_x_at
g4758097_3p_a_at
Participates
as a member of
Tertiary granule lumen proteins [tertiary granule lumen] (Homo sapiens)
Other forms of this molecule
CTSS [lysosomal lumen]
CTSS [early endosome lumen]
CTSS [extracellular region]
CTSS [ficolin-1-rich granule lumen]
CTSS [endolysosome lumen]
Inferred To
CtsL2 [tertiary granule lumen]
(Drosophila melanogaster)
cprB [tertiary granule lumen]
(Dictyostelium discoideum)
cprC [tertiary granule lumen]
(Dictyostelium discoideum)
FP3 [tertiary granule lumen]
(Plasmodium falciparum)
ctss2.1 [tertiary granule lumen]
(Danio rerio)
CTSS [tertiary granule lumen]
(Bos taurus)
CTSS [tertiary granule lumen]
(Canis familiaris)
CTSS [tertiary granule lumen]
(Dictyostelium discoideum)
CTSS [tertiary granule lumen]
(Gallus gallus)
CTSS [tertiary granule lumen]
(Plasmodium falciparum)
CTSS [tertiary granule lumen]
(Sus scrofa)
cprD [tertiary granule lumen]
(Dictyostelium discoideum)
CtsK2 [tertiary granule lumen]
(Drosophila melanogaster)
cpl-1 [tertiary granule lumen]
(Caenorhabditis elegans)
FP2A [tertiary granule lumen]
(Plasmodium falciparum)
FP2B [tertiary granule lumen]
(Plasmodium falciparum)
cprE [tertiary granule lumen]
(Dictyostelium discoideum)
Cp1 [tertiary granule lumen]
(Drosophila melanogaster)
Ctss [tertiary granule lumen]
(Mus musculus)
Ctss [tertiary granule lumen]
(Rattus norvegicus)
Homologues of CTSS [tertiary granule lumen]
(Dictyostelium discoideum)
Homologues of CTSS [tertiary granule lumen]
(Drosophila melanogaster)
Homologues of CTSS [tertiary granule lumen]
(Plasmodium falciparum)
CtsL4 [tertiary granule lumen]
(Drosophila melanogaster)
cprG [tertiary granule lumen]
(Dictyostelium discoideum)
cprF [tertiary granule lumen]
(Dictyostelium discoideum)
ctss [tertiary granule lumen]
(Xenopus tropicalis)
cfaD [tertiary granule lumen]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_004070.3
,
NP_001186668.1
ZINC - World Drugs
CATS_HUMAN
Guide to Pharmacology - Targets
2353
OpenTargets
ENSG00000163131
ZINC - FDA approved
CATS_HUMAN
ZINC - Substances
CATS_HUMAN
ZINC target
P25774
PRO
P25774
PDB
2HH5
,
2H7J
,
1NQC
,
3OVX
,
2G7Y
,
2F1G
,
2FYE
,
3N4C
,
5QBY
,
5QBW
,
5QCE
,
5QBX
,
2R9N
,
5QBU
,
5QC4
,
3N3G
,
5QC3
,
2FQ9
,
6YYR
,
5QC2
,
2G6D
,
5QCH
,
5QC1
,
5QBZ
,
1GLO
,
5QCG
,
5QCF
,
2R9O
,
5QC9
,
5QC7
,
6YYN
,
3IEJ
,
2FUD
,
6YYO
,
5QC8
,
2FT2
,
5QC0
,
1NPZ
,
4P6E
,
2R9M
,
2C0Y
,
5QC6
,
4P6G
,
5QCD
,
1MS6
,
2HHN
,
2HXZ
,
5QCC
,
5QC5
,
2FRQ
,
5QCJ
,
5QBV
,
5QCB
,
2FRA
,
5QCA
,
5QCI
,
6YYP
,
2OP3
,
6YYQ
ZINC - Investigational
CATS_HUMAN
GeneCards
P25774
HPA
ENSG00000163131-CTSS
Ensembl
ENSP00000475176
,
ENST00000472977
,
ENSP00000506001
,
ENST00000681444
,
ENST00000680288
,
ENST00000368985
,
ENSP00000357981
,
ENSP00000505359
,
ENSP00000475557
,
ENST00000607427
,
ENSG00000163131
Pharos - Targets
P25774
ZINC - Predictions - Purchasable
CATS_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14316 IRF2
2
IRF2 [cytosol]
(R-HSA-1015681)
IRF2 [nucleoplasm]
(R-HSA-994031)
0.527
2
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