Reactome: A Curated Pathway Database

MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

Stable Identifier
R-HSA-6801342
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) catalyses the irreversible transformation of 5-formyltetrahydrofolate (5-formyl-THF) to 5,10-methenyltetrahydrofolate (5,10-methenyl-THF) (Dayan et al. 1995). MTHFS has higher affinity for the polyglutamate form of 5-formyl-THF (5-formyl-THFPG) (Bertrand et al. 1987). This reaction of tetrahydrofolate metabolism helps regulate carbon flow through the folate-dependent one-carbon metabolic network which is essential for growth and proliferation of cells.

Literature References
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
5-formyltetrahydrofolate cyclo-ligase activity of MTHFS [cytosol] MTHFS [cytosol] 5-formyltetrahydrofolate cyclo-ligase activity (0030272)
Orthologous Events