Reactome | MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

Stable Identifier

R-HSA-6801342

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG

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Cytosolic 5-formyltetrahydrofolate cyclo-ligase (MTHFS) catalyses the irreversible transformation of 5-formyltetrahydrofolate (5-formyl-THF) to 5,10-methenyltetrahydrofolate (5,10-methenyl-THF) (Dayan et al. 1995). MTHFS has higher affinity for the polyglutamate form of 5-formyl-THF (5-formyl-THFPG) (Bertrand et al. 1987). This reaction of tetrahydrofolate metabolism helps regulate carbon flow through the folate-dependent one-carbon metabolic network which is essential for growth and proliferation of cells.

Literature References

PubMed ID	Title	Journal	Year
8522195	Cloning and characterization of the human 5,10-methenyltetrahydrofolate synthetase-encoding cDNA Filion, M, Skup, D, Mamo, A, Dayan, A, Chahla, D, Massie, B, Bertrand, R, Jolivet, J, Beauchemin, M	Gene	1995
3801490	Human liver methenyltetrahydrofolate synthetase: improved purification and increased affinity for folate polyglutamate substrates MacKenzie, RE, Bertrand, R, Jolivet, J	Biochim. Biophys. Acta	1987