Reactome | DSC1 [ficolin-1-rich granule membrane]

DSC1 [ficolin-1-rich granule membrane]

Stable Identifier

R-HSA-6801378

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule membrane

Synonyms

Desmocollin-1, DSC1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q08554 DSC1

Gene Names

DSC1, CDHF1

Chain

signal peptide:1-29, propeptide:30-134, chain:135-894

Reference Genes

BioGPS Gene:1823 DSC1

COSMIC (genes):DSC1 DSC1

CTD Gene:1823 DSC1

dbSNP Gene:1823 DSC1

ENSEMBL:ENSG00000134765 DSC1

ENSEMBL_homo_sapiens_GENE:ENSG00000134765.10 DSC1

HGNC:3035 DSC1

KEGG Gene (Homo sapiens):1823 DSC1

Monarch:1823 DSC1

NCBI Gene:1823 DSC1

OMIM:125643 DSC1

UCSC:Q08554 DSC1

Reference Transcript

Other Identifiers

11740488_x_at

16854509

1823

207324_PM_s_at

207324_s_at

34619_at

3802987

3803017

3803019

3803021

3803022

3803023

3803024

3803025

3803026

3803027

3803028

3803029

3803030

3803031

3803032

3803033

3803034

3803036

3803037

3803038

3803039

3803040

3803041

8022728

A_23_P38696

GE82835

GO:0001533

GO:0005509

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005921

GO:0007155

GO:0007156

GO:0016020

GO:0030057

GO:0031410

GO:0043226

GO:0046872

GO:0070062

GO:0070161

GO:0098609

GO:0101003

HMNXSV003018277

ILMN_1730284

ILMN_2402640

PH_hs_0023910

TC18000437.hg

X72925_at

g13435362_3p_a_at

Participates

as a member of

Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane] (Homo sapiens)

Other forms of this molecule

DSC1 [cornified envelope]

DSC1 [plasma membrane]

Inferred To

Dsc1 [ficolin-1-rich granule membrane] (Mus musculus)

Dsc1 [ficolin-1-rich granule membrane] (Rattus norvegicus)

cdh-4 [ficolin-1-rich granule membrane] (Caenorhabditis elegans)

DSC1 [ficolin-1-rich granule membrane] (Bos taurus)

DSC1 [ficolin-1-rich granule membrane] (Gallus gallus)

DSC1 [ficolin-1-rich granule membrane] (Sus scrofa)

dsc3 [ficolin-1-rich granule membrane] (Xenopus tropicalis)

dsc2l [ficolin-1-rich granule membrane] (Danio rerio)

Cross References

RefSeq

NP_004939.1, NP_077739.1

OpenTargets

ENSG00000134765

HPA

ENSG00000134765-DSC1

GeneCards

Q08554

Ensembl

ENSP00000257197, ENSP00000257198, ENST00000257198, ENST00000257197, ENSG00000134765

PRO

Q08554

Pharos - Targets

Q08554

HMDB Protein

HMDBP07655

PDB

5IRY

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	5

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