Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
PKM [secretory granule lumen]
Stable Identifier
R-HSA-6801401
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
secretory granule lumen
Synonyms
Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of secretory granule lumen proteins (Homo sapiens)
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
PKM [secretory granule lumen] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14618 PKM
Gene Names
PKM, OIP3, PK2, PK3, PKM2
Chain
initiator methionine:, chain:2-531
Reference Genes
BioGPS Gene:5315 PKM
COSMIC (genes):PKM PKM
CTD Gene:5315 PKM
dbSNP Gene:5315 PKM
ENSEMBL:ENSG00000067225 PKM
HGNC:9021 PKM
KEGG:hsa:5315 PKM
Monarch:5315 PKM
NCBI Gene:5315 PKM
OMIM:179050 PKM
UCSC:P14618 PKM
Reference Transcript
RefSeq:NM_002654.5 PKM
RefSeq:XM_005254445.4 PKM
RefSeq:NM_001206799.1 PKM
RefSeq:NM_182471.3 PKM
RefSeq:NM_001316318.1 PKM
RefSeq:NM_001206796.2 PKM
RefSeq:NM_001206798.2 PKM
RefSeq:NM_182470.3 PKM
RefSeq:NM_001206797.2 PKM
RefSeq:XM_017022313.1 PKM
Participates
as a member of
Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)
Other forms of this molecule
PKM [ficolin-1-rich granule lumen]
PKM [extracellular region]
Inferred To
Dmel\CG12229 [secretory granule lumen]
(Drosophila melanogaster)
pyk-2 [secretory granule lumen]
(Caenorhabditis elegans)
Homologues of PKM [secretory granule lumen]
(Caenorhabditis elegans)
Homologues of PKM [secretory granule lumen]
(Danio rerio)
Homologues of PKM [secretory granule lumen]
(Drosophila melanogaster)
Homologues of PKM [secretory granule lumen]
(Plasmodium falciparum)
Homologues of PKM [secretory granule lumen]
(Saccharomyces cerevisiae)
Pkml1 [secretory granule lumen]
(Rattus norvegicus)
Dmel\CG7362 [secretory granule lumen]
(Drosophila melanogaster)
pklr [secretory granule lumen]
(Danio rerio)
pkma [secretory granule lumen]
(Danio rerio)
pyk-1 [secretory granule lumen]
(Caenorhabditis elegans)
Dmel\CG7069 [secretory granule lumen]
(Drosophila melanogaster)
Dmel\CG11249 [secretory granule lumen]
(Drosophila melanogaster)
Dmel\CG2964 [secretory granule lumen]
(Drosophila melanogaster)
PKM [secretory granule lumen]
(Bos taurus)
PKM [secretory granule lumen]
(Dictyostelium discoideum)
PKM [secretory granule lumen]
(Drosophila melanogaster)
PKM [secretory granule lumen]
(Gallus gallus)
PKM [secretory granule lumen]
(Mus musculus)
PKM [secretory granule lumen]
(Plasmodium falciparum)
PKM [secretory granule lumen]
(Saccharomyces cerevisiae)
PKM [secretory granule lumen]
(Schizosaccharomyces pombe)
PKM [secretory granule lumen]
(Sus scrofa)
pkm [secretory granule lumen]
(Xenopus tropicalis)
Cross References
RefSeq
NP_002645.3
,
NP_872270.1
,
XP_016877802.1
,
NP_872271.1
,
NP_001193728.1
,
NP_001193727.1
,
NP_001193726.1
,
XP_005254502.1
,
NP_001193725.1
,
NP_001303247.1
Guide to Pharmacology - Targets
3006
OpenTargets
ENSG00000067225
ENSEMBL
ENSP00000320171
,
ENSP00000334983
,
ENSP00000456970
,
ENST00000335181
,
ENST00000319622
,
ENSG00000067225
,
ENST00000568459
ZINC - Substances
KPYM_HUMAN
ZINC - Biogenic
KPYM_HUMAN
ZINC target
P14618
PRO
P14618
GlyGen
P14618
PDB
6V74
,
3SRH
,
3ME3
,
4FXJ
,
6WP3
,
8HMR
,
3SRF
,
4QG9
,
3H6O
,
4B2D
,
4YJ5
,
6V75
,
6WP5
,
6JFB
,
4RPP
,
3GQY
,
3BJF
,
6NUB
,
7L21
,
1ZJH
,
6TTF
,
3G2G
,
6TTQ
,
6TTH
,
3SRD
,
6B6U
,
8HMU
,
6GG5
,
6WP4
,
4FXF
,
4QG8
,
8HMQ
,
8HMS
,
1T5A
,
6GG6
,
4G1N
,
6V76
,
6WP6
,
4JPG
,
4WJ8
,
8HGF
,
3U2Z
,
3GR4
,
5X0I
,
3BJT
,
6NU5
,
5X1V
,
5X1W
,
6GG3
,
6NU1
,
6TTI
,
4QGC
,
4QG6
,
6GG4
,
8G2E
ZINC - Metabolites
KPYM_HUMAN
HPA
ENSG00000067225-PKM
GeneCards
PKM
Pharos - Targets
P14618
ZINC - Predictions - Purchasable
KPYM_HUMAN
HMDB Protein
HMDBP00763
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
9
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
20
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
CTNNB1 [nucleoplasm]
(R-HSA-3451168)
CTNNB1 [cytosol]
(R-HSA-448839)
CTNNB1(1-115) [cytosol]
(R-HSA-202930)
CTNNB1(116-376) [cytosol]
(R-HSA-202950)
p-S33,S37,T41,S45 CTNNB1 [cytosol]
(R-HSA-8942374)
p-S37,T41,S45, CTNNB1 [cytosol]
(R-HSA-8942369)
p-T41,S45 CTNNB1 [cytosol]
(R-HSA-8942367)
p-S45 CTNNB1 [cytosol]
(R-HSA-8942363)
CTNNB1 [plasma membrane]
(R-HSA-9038440)
p-S552-CTNNB1 [cytosol]
(R-HSA-3134933)
p-S552-CTNNB1 [nucleoplasm]
(R-HSA-3134926)
p-Y-CTNNB1 [cytosol]
(R-HSA-8876940)
0.524
4
UniProt:P32121 ARRB2
3
ARRB2 [cytosol]
(R-HSA-416464)
PolyUb-ARRB2 [cytosol]
(R-HSA-6783000)
ARRB2 [endocytic vesicle membrane]
(R-HSA-9910881)
0.499
4
UniProt:P49407 ARRB1
6
ARRB1 [cytosol]
(R-HSA-264470)
PolyUb-ARRB1 [cytosol]
(R-HSA-6783186)
ARRB1 [endocytic vesicle membrane]
(R-HSA-9910882)
ARRB1 [lysosomal membrane]
(R-HSA-432701)
ARRB1 [Golgi membrane]
(R-HSA-350831)
ARRB1 [cytoplasmic vesicle membrane]
(R-HSA-351187)
0.499
3
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text