Reactome | PKM [secretory granule lumen]

PKM [secretory granule lumen]

Stable Identifier

R-HSA-6801401

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14618 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Chain

initiator methionine:, chain:2-531

Reference Genes

BioGPS Gene:5315 PKM

COSMIC (genes):PKM PKM

CTD Gene:5315 PKM

dbSNP Gene:5315 PKM

ENSEMBL:ENSG00000067225 PKM

HGNC:9021 PKM

KEGG:hsa:5315 PKM

Monarch:5315 PKM

NCBI Gene:5315 PKM

OMIM:179050 PKM

UCSC:P14618 PKM

Reference Transcript

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PKM [ficolin-1-rich granule lumen]

PKM [extracellular region]

Inferred To

Dmel\CG12229 [secretory granule lumen] (Drosophila melanogaster)

pyk-2 [secretory granule lumen] (Caenorhabditis elegans)

Homologues of PKM [secretory granule lumen] (Caenorhabditis elegans)

Homologues of PKM [secretory granule lumen] (Danio rerio)

Homologues of PKM [secretory granule lumen] (Drosophila melanogaster)

Homologues of PKM [secretory granule lumen] (Plasmodium falciparum)

Homologues of PKM [secretory granule lumen] (Saccharomyces cerevisiae)

Pkml1 [secretory granule lumen] (Rattus norvegicus)

Dmel\CG7362 [secretory granule lumen] (Drosophila melanogaster)

pklr [secretory granule lumen] (Danio rerio)

pkma [secretory granule lumen] (Danio rerio)

pyk-1 [secretory granule lumen] (Caenorhabditis elegans)

Dmel\CG7069 [secretory granule lumen] (Drosophila melanogaster)

Dmel\CG11249 [secretory granule lumen] (Drosophila melanogaster)

Dmel\CG2964 [secretory granule lumen] (Drosophila melanogaster)

PKM [secretory granule lumen] (Bos taurus)

PKM [secretory granule lumen] (Dictyostelium discoideum)

PKM [secretory granule lumen] (Drosophila melanogaster)

PKM [secretory granule lumen] (Gallus gallus)

PKM [secretory granule lumen] (Mus musculus)

PKM [secretory granule lumen] (Plasmodium falciparum)

PKM [secretory granule lumen] (Saccharomyces cerevisiae)

PKM [secretory granule lumen] (Schizosaccharomyces pombe)

PKM [secretory granule lumen] (Sus scrofa)

pkm [secretory granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_002645.3, NP_872270.1, XP_016877802.1, NP_872271.1, NP_001193728.1, NP_001193727.1, NP_001193726.1, XP_005254502.1, NP_001193725.1, NP_001303247.1

Guide to Pharmacology - Targets

3006

OpenTargets

ENSG00000067225

ENSEMBL

ENSP00000320171, ENSP00000334983, ENSP00000456970, ENST00000335181, ENST00000319622, ENSG00000067225, ENST00000568459

ZINC - Substances

KPYM_HUMAN

ZINC - Biogenic

KPYM_HUMAN

ZINC target

P14618

PRO

P14618

GlyGen

P14618

PDB

6V74, 3SRH, 3ME3, 4FXJ, 6WP3, 8HMR, 3SRF, 4QG9, 3H6O, 4B2D, 4YJ5, 6V75, 6WP5, 6JFB, 4RPP, 3GQY, 3BJF, 6NUB, 7L21, 1ZJH, 6TTF, 3G2G, 6TTQ, 6TTH, 3SRD, 6B6U, 8HMU, 6GG5, 6WP4, 4FXF, 4QG8, 8HMQ, 8HMS, 1T5A, 6GG6, 4G1N, 6V76, 6WP6, 4JPG, 4WJ8, 8HGF, 3U2Z, 3GR4, 5X0I, 3BJT, 6NU5, 5X1V, 5X1W, 6GG3, 6NU1, 6TTI, 4QGC, 4QG6, 6GG4, 8G2E

ZINC - Metabolites

KPYM_HUMAN

HPA

ENSG00000067225-PKM

GeneCards

PKM

Pharos - Targets

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

HMDB Protein

HMDBP00763

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	9
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) CTNNB1 [nucleoplasm] (R-HSA-3451168) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1(116-376) [cytosol] (R-HSA-202950) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-Y-CTNNB1 [cytosol] (R-HSA-8876940)	0.524	4
UniProt:P32121 ARRB2	3	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [endocytic vesicle membrane] (R-HSA-9910881)	0.499	4
UniProt:P49407 ARRB1	6	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [endocytic vesicle membrane] (R-HSA-9910882) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3