Reactome | PKM [secretory granule lumen]

PKM [secretory granule lumen]

Stable Identifier

R-HSA-6801401

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14618 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Chain

initiator methionine:1, chain:2-531

Reference Genes

BioGPS Gene:5315 PKM

COSMIC (genes):PKM PKM

CTD Gene:5315 PKM

dbSNP Gene:5315 PKM

ENSEMBL:ENSG00000067225 PKM

HGNC:9021 PKM

KEGG Gene (Homo sapiens):5315 PKM

Monarch:5315 PKM

NCBI Gene:5315 PKM

OMIM:179050 PKM

UCSC:P14618 PKM

Reference Transcript

Other Identifiers

0002030537

0006200152

0006510452

11722787_a_at

11752165_s_at

11752166_x_at

11752342_x_at

11752458_a_at

11756971_x_at

16811372

201251_PM_at

201251_at

2893336

2893342

3103883

3103886

3103891

3103895

32378_at

3631965

3631966

3631967

3631968

3631969

3631971

3631977

3631984

3631989

3631992

3631993

3631998

3631999

3632000

3632003

3632005

3632007

3632010

3632011

3632029

3632030

3632031

3632032

3632033

3632034

3632035

3632036

3979839

5315

7990151

A_23_P399501

A_32_P147241

GE81173

GO:0000166

GO:0000287

GO:0003674

GO:0003723

GO:0003729

GO:0003824

GO:0004743

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005739

GO:0005783

GO:0005791

GO:0005829

GO:0005929

GO:0005975

GO:0006091

GO:0006096

GO:0006412

GO:0006417

GO:0008150

GO:0008152

GO:0008219

GO:0009056

GO:0009058

GO:0012501

GO:0016301

GO:0016310

GO:0016740

GO:0023026

GO:0030312

GO:0030955

GO:0031012

GO:0031410

GO:0031982

GO:0032869

GO:0034641

GO:0034774

GO:0043167

GO:0043226

GO:0044281

GO:0045296

GO:0046872

GO:0048646

GO:0048856

GO:0062023

GO:0070062

GO:1903561

GO:1903672

GO:1904813

GO:2000767

HMNXSV003020043

ILMN_1663122

ILMN_1672650

ILMN_1775327

ILMN_2366634

PH_hs_0029415

TC15002609.hg

TC15002610.hg

TC15002776.hg

X56494_at

g4505838_3p_at

g4505838_3p_x_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

PKM [extracellular region]

PKM [ficolin-1-rich granule lumen]

Inferred To

Pkm [secretory granule lumen] (Mus musculus)

Dmel\CG12229 [secretory granule lumen] (Drosophila melanogaster)

pyk-2 [secretory granule lumen] (Caenorhabditis elegans)

pyk1 [secretory granule lumen] (Schizosaccharomyces pombe)

LOC100362738 [secretory granule lumen] (Rattus norvegicus)

PYK2 [secretory granule lumen] (Saccharomyces cerevisiae)

Homologues of PKM [secretory granule lumen] (Caenorhabditis elegans)

Homologues of PKM [secretory granule lumen] (Danio rerio)

Homologues of PKM [secretory granule lumen] (Drosophila melanogaster)

Homologues of PKM [secretory granule lumen] (Plasmodium falciparum)

Homologues of PKM [secretory granule lumen] (Saccharomyces cerevisiae)

Dmel\CG7362 [secretory granule lumen] (Drosophila melanogaster)

pklr [secretory granule lumen] (Danio rerio)

pkma [secretory granule lumen] (Danio rerio)

CDC19 [secretory granule lumen] (Saccharomyces cerevisiae)

pyk-1 [secretory granule lumen] (Caenorhabditis elegans)

Dmel\CG7069 [secretory granule lumen] (Drosophila melanogaster)

PyK [secretory granule lumen] (Drosophila melanogaster)

pyk [secretory granule lumen] (Dictyostelium discoideum)

Dmel\CG11249 [secretory granule lumen] (Drosophila melanogaster)

Dmel\CG2964 [secretory granule lumen] (Drosophila melanogaster)

PKM [secretory granule lumen] (Bos taurus)

PKM [secretory granule lumen] (Gallus gallus)

PKM [secretory granule lumen] (Plasmodium falciparum)

PKM [secretory granule lumen] (Sus scrofa)

pkm [secretory granule lumen] (Xenopus tropicalis)

pkmb [secretory granule lumen] (Danio rerio)

Cross References

RefSeq

NP_002645.3, XP_016877802.1, NP_001193728.1, NP_001193726.1, NP_872271.1, NP_001193727.1, NP_001193725.1, XP_005254502.1, NP_001303247.1, NP_872270.1

Guide to Pharmacology - Targets

3006

OpenTargets

ENSG00000067225

ZINC - Substances

KPYM_HUMAN

ZINC - Biogenic

KPYM_HUMAN

ZINC target

P14618

PRO

P14618

PDB

4QG8, 6WP4, 4G1N, 3BJF, 6WP3, 4JPG, 6NUB, 6TTH, 6WP5, 4B2D, 4WJ8, 4QG9, 3U2Z, 3SRH, 3G2G, 4RPP, 6GG3, 6B6U, 6V74, 6GG4, 4YJ5, 6WP6, 1T5A, 4FXF, 3SRF, 3ME3, 6TTI, 6GG5, 4QGC, 3H6O, 6JFB, 3SRD, 3GR4, 6TTQ, 5X1V, 3BJT, 4FXJ, 6GG6, 3GQY, 6V75, 5X0I, 6V76, 5X1W, 4QG6, 6NU1, 1ZJH, 6NU5, 6TTF

ZINC - Metabolites

KPYM_HUMAN

HPA

ENSG00000067225-PKM

GeneCards

P14618

Ensembl

ENSP00000320171, ENSP00000456970, ENST00000335181, ENSP00000334983, ENST00000568459, ENST00000319622, ENSG00000067225

Pharos - Targets

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

HMDB Protein

HMDBP00763

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	9
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.527	2
UniProt:P35222 CTNNB1	20	CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612)	0.524	4
UniProt:P32121 ARRB2	2	ARRB2 [cytosol] (R-HSA-416464) PolyUb-ARRB2 [cytosol] (R-HSA-6783000)	0.499	4
UniProt:P49407 ARRB1	5	ARRB1 [cytosol] (R-HSA-264470) PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3

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