Reactome | PKM [secretory granule lumen]

PKM [secretory granule lumen]

Stable Identifier

R-HSA-6801401

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Pyruvate kinase PKM ecNumber2.7.1.40/ecNumber, KPYM_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P14618 PKM

Gene Names

PKM, OIP3, PK2, PK3, PKM2

Chain

initiator methionine:1, chain:2-531

Reference Genes

BioGPS Gene:5315 PKM

COSMIC (genes):PKM PKM

CTD Gene:5315 PKM

dbSNP Gene:5315 PKM

ENSEMBL:ENSG00000067225 PKM

HGNC:9021 PKM

KEGG Gene (Homo sapiens):5315 PKM

Monarch:5315 PKM

NCBI Gene:5315 PKM

OMIM:179050 PKM

UCSC:P14618 PKM

Reference Transcript

Other Identifiers

00010+2.7.1.40

0002030537

0006200152

0006510452

00230+2.7.1.40

00620+2.7.1.40

11722787_a_at

11752165_s_at

11752166_x_at

11752342_x_at

11752458_a_at

11756971_x_at

16811372

19421

1T5A

1ZJH

201251_at

2893336

2893342

29501

3103883

3103886

3103891

3103895

32378_at

3631965

3631966

3631967

3631968

3631969

3631971

3631977

3631984

3631989

3631992

3631993

3631998

3631999

3632000

3632003

3632005

3632007

3632010

3632011

3632015

3632029

3632030

3632031

3632032

3632033

3632034

3632035

3632036

3979839

3BJF

3BJT

3G2G

3GQY

3GR4

3H6O

3ME3

3SRD

3SRF

3SRH

3U2Z

4B2D

4FXF

4FXJ

4G1N

4JPG

4QG6

4QG8

4QG9

4QGC

4RPP

4WJ8

4YJ5

5315

5X0I

5X1V

5X1W

6B6U

6GG4

6GG5

6GG6

7990151

A0A024R5Z9

A_23_P399501

A_32_P147241

AAA36449

AAA36672

AAC39559

AAH00481

AAH07640

AAH07952

AAH12811

AAH35198

AAQ15274

AC020779

ACJ13685

AF025439

AK092369

AK222927

AK294315

AK300800

AK312253

AY352517

B4DNK4

BAD96647

BAG35185

BAG52542

BAG57589

BAG62458

BC000481

BC007640

BC007952

BC012811

BC035198

CAA39849

CAB019421

CCDS32284

CCDS32285

CCDS55972

CH471082

EAW77884

EAW77888

EAW77890

ENSG00000067225

ENSP00000320171

ENSP00000334983

ENSP00000403365

ENSP00000455736

ENSP00000455901

ENSP00000456970

ENST00000319622

ENST00000319622.10

ENST00000335181

ENST00000335181.9

ENST00000449901

ENST00000449901.6

ENST00000565154

ENST00000565154.5

ENST00000565184

ENST00000565184.5

ENST00000568459

ENST00000568459.5

EntrezGene:5315

EntrezGene:PKM

EU794631

g4505838_3p_at

g4505838_3p_x_at

GE81173

GO:0000166

GO:0000287

GO:0001666

GO:0001889

GO:0002376

GO:0003674

GO:0003723

GO:0003824

GO:0004743

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005829

GO:0005929

GO:0005975

GO:0006006

GO:0006091

GO:0006096

GO:0006754

GO:0006810

GO:0006950

GO:0007584

GO:0008150

GO:0008152

GO:0008219

GO:0009056

GO:0009058

GO:0009629

GO:0010033

GO:0012501

GO:0014870

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0022607

GO:0023026

GO:0030955

GO:0031012

GO:0031100

GO:0031410

GO:0031982

GO:0032868

GO:0032869

GO:0032991

GO:0034641

GO:0034774

GO:0040007

GO:0042802

GO:0042866

GO:0043167

GO:0043226

GO:0043312

GO:0043403

GO:0043531

GO:0044281

GO:0045296

GO:0046872

GO:0048646

GO:0048856

GO:0051289

GO:0061621

GO:0062023

GO:0065003

GO:0070062

GO:0070324

GO:1902912

GO:1903561

GO:1903672

GO:1904813

H3BN34

H3BQ34

H3BQZ3

H3BR70

H3BT25

H3BTJ2

H3BTN5

H3BU13

H3BUW1

HEL-S-30

HGNC:9021

HPA029501

ILMN_1663122

ILMN_1672650

ILMN_1775327

ILMN_2366634

IPR001697

IPR011037

IPR015793

IPR015795

IPR015806

IPR015813

IPR018209

IPR036918

IPR040442

M23725

M26252

MIM:179050

NM_001206796

NM_001206798

NM_001206799

NM_001316318

NM_002654

NM_182470

NM_182471

NP_001193725

NP_001193727

NP_001193728

NP_001303247

NP_002645

NP_872270

NP_872271

PF00224

PF02887

PH_hs_0029415

PKM

PKM-201

PKM-202

PKM-204

PKM-215

PKM-216

PKM-220

PKM2

PR01050

TC15002609.hg

TC15002610.hg

TC15002776.hg

UPI000014064D

UPI0000169DBC

UPI00017A7FFA

V9HWB8

X56494

X56494_at

XM_005254443

XM_005254445

XM_006720570

XM_011521670

XM_017022313

XP_005254500

XP_005254502

XP_006720633

XP_011519972

XP_016877802

XR_001751314

Participant Of

hasMember

Secretory granule lumen proteins [secretory granule lumen]

Other forms of this molecule

PKM [extracellular region]

PKM [ficolin-1-rich granule lumen]

Inferred To

Homologues of PKM [secretory granule lumen] (Caenorhabditis elegans)

Homologues of PKM [secretory granule lumen] (Danio rerio)

Homologues of PKM [secretory granule lumen] (Drosophila melanogaster)

Homologues of PKM [secretory granule lumen] (Plasmodium falciparum)

Homologues of PKM [secretory granule lumen] (Saccharomyces cerevisiae)

PKM [secretory granule lumen] (Bos taurus)

PKM [secretory granule lumen] (Caenorhabditis elegans)

PKM [secretory granule lumen] (Canis familiaris)

PKM [secretory granule lumen] (Danio rerio)

PKM [secretory granule lumen] (Dictyostelium discoideum)

PKM [secretory granule lumen] (Drosophila melanogaster)

PKM [secretory granule lumen] (Gallus gallus)

PKM [secretory granule lumen] (Mus musculus)

PKM [secretory granule lumen] (Plasmodium falciparum)

PKM [secretory granule lumen] (Rattus norvegicus)

PKM [secretory granule lumen] (Saccharomyces cerevisiae)

PKM [secretory granule lumen] (Schizosaccharomyces pombe)

PKM [secretory granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001193726.1, NP_001193728.1, XP_016877802.1, NP_872270.1, NP_001193725.1, NP_001193727.1, NP_872271.1, NP_002645.3, NP_001303247.1, XP_005254502.1

ZINC - Metabolites

KPYM_HUMAN

OpenTargets

ENSG00000067225

GeneCards

P14618

ZINC - Substances

KPYM_HUMAN

ZINC target

P14618

ZINC - Biogenic

KPYM_HUMAN

PRO

P14618

ZINC - Predictions - Purchasable

KPYM_HUMAN

PDB

6GG5, 4QGC, 5X0I, 5X1W, 3SRD, 3U2Z, 3GQY, 4QG6, 1T5A, 4FXJ, 3H6O, 1ZJH, 3G2G, 3BJT, 6GG3, 4RPP, 6GG6, 6NU5, 4QG9, 4G1N, 3BJF, 6NUB, 4QG8, 3SRH, 4FXF, 4B2D, 4YJ5, 3GR4, 6NU1, 6B6U, 4WJ8, 4JPG, 3ME3, 6GG4, 3SRF, 5X1V

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.524	4
UniProt:P32121 ARRB2	2	PolyUb-ARRB2 [cytosol] (R-HSA-6783000) ARRB2 [cytosol] (R-HSA-416464)	0.499	4
UniProt:P49407 ARRB1	5	PolyUb-ARRB1 [cytosol] (R-HSA-6783186) ARRB1 [cytosol] (R-HSA-264470) ARRB1 [lysosomal membrane] (R-HSA-432701) ARRB1 [Golgi membrane] (R-HSA-350831) ARRB1 [cytoplasmic vesicle membrane] (R-HSA-351187)	0.499	3