MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF

Stable Identifier
R-HSA-6801462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mammalian mitochondria are able to produce formate from one-carbon (1C) donors such as serine, glycine and sarcosine. In mitochondria, the 1C units are oxidised to formate and transported to the cytosol, where the formate is reattached to tetrahydrofolate (THF) for use in de novo purine biosynthesis. The mitochondrial bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolases D2 and D2L (MTHFD2, MTHFD2L) mediate reversible reactions to convert 5,10-methylene-THF, via 5,10-methenyl-THF, to 10-formyl-THF. These enzymes have filled in missing gaps which existed in the transformation of 5,10-methylene-THF to formate in human mitochondria (Yang & MacKenzie 1993, Bolusani et al. 2011, Shin et al. 2014).

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
methylenetetrahydrofolate dehydrogenase (NAD+) activity of MTHFD2, D2L [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
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