Reactome | HSP90AB1 [secretory granule lumen]

HSP90AB1 [secretory granule lumen]

Stable Identifier

R-HSA-6801477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Heat shock protein HSP 90-beta, HS90B_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08238 HSP90AB1

Gene Names

HSP90AB1, HSP90B, HSPC2, HSPCB

Chain

initiator methionine:1, chain:2-724

Reference Genes

BioGPS Gene:3326 HSP90AB1

COSMIC (genes):HSP90AB1 HSP90AB1

CTD Gene:3326 HSP90AB1

dbSNP Gene:3326 HSP90AB1

ENSEMBL:ENSG00000096384 HSP90AB1

ENSEMBL:ENSG00000096384.20 HSP90AB1

HGNC:5258 HSP90AB1

KEGG Gene (Homo sapiens):3326 HSP90AB1

Monarch:3326 HSP90AB1

NCBI Gene:3326 HSP90AB1

OMIM:140572 HSP90AB1

UCSC:P08238 HSP90AB1

Reference Transcript

Other Identifiers

1161_at

11723417_s_at

1557910_PM_at

1557910_at

16656615

16656617

17009217

18670460

18670461

18670462

18670463

18670464

200064_PM_at

200064_at

214359_PM_s_at

214359_s_at

2719007

2719013

2735193

2735196

2735198

2735199

2735200

2735203

2735204

2735209

2735210

2735211

2735212

2908477

2908481

2908482

2908483

2908485

2908486

2908487

2908488

2908489

2908491

2908492

2908494

2908495

2908497

2908498

2908499

2908500

2908501

2908502

2908503

2908505

2908508

2908509

2908510

2908511

2908512

3326

33984_at

7892509

7892652

7892902

7893138

7893191

7893244

7893264

7893316

7893547

7893650

7893762

7893769

7894012

7894366

7894429

7894672

7894798

7895123

7895328

7895585

7895953

7896022

8119993

A_14_P109676

A_23_P145089

A_24_P170295

GE57843

GO:0000166

GO:0001890

GO:0003723

GO:0003725

GO:0003824

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005886

GO:0006457

GO:0006986

GO:0007004

GO:0007163

GO:0008092

GO:0008180

GO:0009986

GO:0010033

GO:0012501

GO:0016020

GO:0016787

GO:0016887

GO:0019062

GO:0019887

GO:0019899

GO:0019900

GO:0019901

GO:0021955

GO:0023026

GO:0023052

GO:0030010

GO:0030154

GO:0030163

GO:0030235

GO:0030511

GO:0030911

GO:0031072

GO:0031396

GO:0031410

GO:0031625

GO:0032200

GO:0032435

GO:0032516

GO:0032880

GO:0032991

GO:0033138

GO:0034605

GO:0034751

GO:0034774

GO:0036211

GO:0042277

GO:0042470

GO:0042802

GO:0042803

GO:0042826

GO:0043008

GO:0043025

GO:0043066

GO:0043226

GO:0044183

GO:0044294

GO:0044295

GO:0045296

GO:0045429

GO:0045597

GO:0046983

GO:0048156

GO:0048471

GO:0048675

GO:0048856

GO:0050821

GO:0051082

GO:0051131

GO:0051248

GO:0051726

GO:0051897

GO:0051973

GO:0065003

GO:0070062

GO:0070182

GO:0071353

GO:0097435

GO:0097718

GO:0098772

GO:0120293

GO:0140657

GO:0140662

GO:1901389

GO:1901799

GO:1902949

GO:1904031

GO:1904813

GO:1905323

GO:1990226

GO:1990565

GO:2000010

HMNXSV003041712

Hs.74335.1.S1_3p_a_at

Hs2.434250.1.S1_3p_s_at

ILMN_1673711

J04988_at

PH_hs_0028959

PH_hs_0031307

TC06000615.hg

g9082288_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

HSP90AB1 [extracellular region]

HSP90AB1 [ficolin-1-rich granule lumen]

HSP90AB1 [cytosol]

HSP90AB1 [nucleoplasm]

HSP90AB1 [lysosomal lumen]

Inferred To

HSP90AB1 [secretory granule lumen] (Bos taurus)

HSP90AB1 [secretory granule lumen] (Caenorhabditis elegans)

HSP90AB1 [secretory granule lumen] (Canis familiaris)

HSP90AB1 [secretory granule lumen] (Danio rerio)

HSP90AB1 [secretory granule lumen] (Dictyostelium discoideum)

HSP90AB1 [secretory granule lumen] (Drosophila melanogaster)

HSP90AB1 [secretory granule lumen] (Gallus gallus)

HSP90AB1 [secretory granule lumen] (Mus musculus)

HSP90AB1 [secretory granule lumen] (Plasmodium falciparum)

HSP90AB1 [secretory granule lumen] (Rattus norvegicus)

HSP90AB1 [secretory granule lumen] (Saccharomyces cerevisiae)

HSP90AB1 [secretory granule lumen] (Schizosaccharomyces pombe)

HSP90AB1 [secretory granule lumen] (Sus scrofa)

hsp90ab1 [secretory granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

NP_001258900.1, NP_001258899.1, NP_031381.2, NP_001258898.1

Guide to Pharmacology - Targets

2907

OpenTargets

ENSG00000096384

ZINC - Substances

HS90B_HUMAN

ZINC target

P08238

ZINC - Biogenic

HS90B_HUMAN

PRO

P08238

PDB

7ZR5, 7ZR6, 8EOA, 5UC4, 3NMQ, 8EOB, 2L6J, 3UQ3, 5UCH, 5UCI, 3PRY, 3FWV, 5UCJ, 5FWK, 1UYM, 5FWL, 1QZ2, 5FWM, 7ZUB, 7Z37, 7ZR0, 5FWP, 6N8W, 7Z38, 6N8Y

ZINC - Investigational

HS90B_HUMAN

HPA

ENSG00000096384-HSP90AB1

GeneCards

P08238

Ensembl

ENSP00000360609, ENST00000371646, ENST00000371554, ENSP00000481908, ENSP00000360709, ENST00000620073, ENST00000353801, ENSG00000096384, ENSP00000325875

Pharos - Targets

P08238

ZINC - Predictions - Purchasable

HS90B_HUMAN

HMDB Protein

HMDBP14537

Interactors (152)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.89	10
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.889	11
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.867	8
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.857	17
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.849	16
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.832	11
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.829	8
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.81	9
UniProt:Q9UHD1 CHRD1			0.801	6
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.793	5
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108)	0.793	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.788	7
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830)	0.784	5
UniProt:Q96GD4 AURKB	3	polySUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [nucleoplasm] (R-HSA-4655360) AURKB [cytosol] (R-HSA-174231)	0.784	5
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.761	4
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) K48polyUb-NIK [cytosol] (R-HSA-5668525) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187)	0.758	6
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.744	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.743	5
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [extracellular region] (R-HSA-8848918) CDC37L1 [platelet dense granule lumen] (R-HSA-8848903)	0.743	5
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.723	5
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.723	5
UniProt:O95433 AHSA1			0.702	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.688	4
UniProt:O95801 TTC4			0.682	5
UniProt:Q9BXA6 TSSK6			0.669	4
UniProt:Q08881 ITK	3	p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) p-Y512-ITK [cytosol] (R-HSA-422519) ITK [cytosol] (R-HSA-202319)	0.669	3
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,S732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,S732-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,S732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.669	4
UniProt:P11362 FGFR1	9	FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241) FGFR1 K656E [plasma membrane] (R-HSA-1614373) FGFR1 N546K [plasma membrane] (R-HSA-1614377) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 [plasma membrane] (R-HSA-9756433)	0.669	3
UniProt:Q6J9G0 STYK1			0.669	3
UniProt:Q92918 M4K1			0.669	4
UniProt:Q96QS6 KPSH2			0.669	3
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.669	4
UniProt:Q8N165 PDK1L			0.669	3
UniProt:Q86YV6 MYLK4			0.669	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.669	3
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.669	4
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.669	3
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.669	4
UniProt:P15056 BRAF	20	BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165)	0.669	4
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.667	4
UniProt:P41279 MAP3K8	3	p-S400-MAP3K8 [cytosol] (R-HSA-389738) MAP3K8 [cytosol] (R-HSA-389388) p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259)	0.656	3
UniProt:O14757 CHEK1	3	CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.656	3
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.646	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.643	9
UniProt:P51817 PRKX	1	PRKX [nucleoplasm] (R-HSA-3222308)	0.641	3
UniProt:P53671 LIMK2	2	LIMK2 [cytosol] (R-HSA-419171) p-T505-LIMK2 [cytosol] (R-HSA-419711)	0.641	3
UniProt:P11801 KPSH1			0.641	3
UniProt:Q96S53 TESK2			0.641	3
UniProt:Q13618 CUL3	3	CUL3 [cytosol] (R-HSA-975979) CUL3 [nucleoplasm] (R-HSA-5635033) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.641	3
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.641	4
UniProt:Q15131 CDK10			0.641	3
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116)	0.641	4
UniProt:Q9UPZ9 CILK1			0.641	3
UniProt:P31152 MAPK4	4	MAPK4 [nucleoplasm] (R-HSA-5686975) MAPK4 [cytosol] (R-HSA-5686973) p-S186 MAPK4 [cytosol] (R-HSA-5687023) p-S186 MAPK4 [nucleoplasm] (R-HSA-5687022)	0.641	3
UniProt:Q02156 PRKCE	2	p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260) PRKCE [cytosol] (R-HSA-58202)	0.641	4
UniProt:Q16832 DDR2	1	DDR2 [plasma membrane] (R-HSA-211419)	0.641	3
UniProt:Q2WGJ6 KLH38			0.641	3
UniProt:P35916 FLT4	1	FLT4 [plasma membrane] (R-HSA-195359)	0.641	3
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019)	0.615	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16
UniProt:P14616 INSRR			0.604	3
UniProt:O15197 EPHB6	6	EPHB6 (?-?) [plasma membrane] (R-HSA-3928399) EPHB6 (?-1021) [cytosol] (R-HSA-3928398) EPHB6 (?-1021) [plasma membrane] (R-HSA-3928469) EPHB6 (32-?) [extracellular region] (R-HSA-3928437) EPHB6 [plasma membrane] (R-HSA-2682336) p-Y645,Y651-EPHB6 [plasma membrane] (R-HSA-3928334)	0.604	3
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.604	3
UniProt:Q9UHD2 TBK1	4	pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) p-TBK1 [cytosol] (R-HSA-9008705) p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267)	0.589	3
UniProt:Q13546 RIPK1	20	K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 [plasma membrane] (R-HSA-937073) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K48polyUb-K571,K604,K627-RIPK1 [cytosol] (R-HSA-9796639) K63,Met1polyUb-p-S25-RIPK1 [cytosol] (R-HSA-9818793) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1(325-671) [cytosol] (R-HSA-5212671) K63,M1polyUb-RIPK1 [cytosol] (R-HSA-9793681) polyUb-K377,K604,K634-RIPK1 [cytosol] (R-HSA-9818391) K63,M1polyUb, p-T189-RIPK1 [cytosol] (R-HSA-9817377) p-S320-RIPK1 [cytosol] (R-HSA-9815498) p-S357-RIPK1 [cytosol] (R-HSA-9819116) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 [cytosol] (R-HSA-168651)	0.589	2
UniProt:Q14164 IKBKE	4	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	3
UniProt:Q9H1R3 MYLK2			0.564	3
UniProt:Q8NG66 NEK11			0.564	2
UniProt:Q9BXA7 TSSK1			0.564	2
UniProt:P51812 RPS6KA3	7	RPS6KA3 [nucleoplasm] (R-HSA-199869) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) RPS6KA3 [cytosol] (R-HSA-444250) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286)	0.564	3
UniProt:Q86UX6 ST32C			0.564	2
UniProt:Q86SG6 NEK8			0.564	2
UniProt:Q07912 ACK1			0.564	3
UniProt:Q9HBY8 SGK2	1	SGK2 [cytosol] (R-HSA-2682364)	0.564	2
UniProt:P05129 PRKCG	1	PRKCG [cytosol] (R-HSA-58204)	0.564	2
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.564	2
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206) p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935)	0.564	2
UniProt:Q9BQI3 EIF2AK1	2	p-T-EIF2AK1 [cytosol] (R-HSA-9648892) p-T,T486,T488-EIF2AK1 [cytosol] (R-HSA-9648894)	0.564	2
UniProt:Q8WXR4 MYO3B	1	MYO3B [cytosol] (R-HSA-9663316)	0.564	2
UniProt:Q13616 CUL1	3	G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [nucleoplasm] (R-HSA-187551) CUL1 [cytosol] (R-HSA-174230)	0.564	2
UniProt:P49761 CLK3			0.564	2
UniProt:Q13619 CUL4A	2	CUL4A [nucleoplasm] (R-HSA-976006) G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514)	0.564	2
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [nucleoplasm] (R-HSA-1234126) CUL2 [cytosol] (R-HSA-416982)	0.564	2
UniProt:O75426 FBX24			0.564	2
UniProt:Q06418 TYRO3			0.564	2
UniProt:Q9UKC9 FBXL2			0.564	2
UniProt:P00540 MOS			0.564	2
UniProt:P21860 ERBB3			0.564	3
UniProt:Q13620 CUL4B	2	CUL4B [nucleoplasm] (R-HSA-975973) G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522)	0.564	2
UniProt:Q00526 CDK3			0.564	2
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.564	2
UniProt:Q8TD08 MK15			0.564	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.564	3
UniProt:Q9NR20 DYRK4			0.564	2
UniProt:P16591 FER	1	FER [cytosol] (R-HSA-1433364)	0.564	2
UniProt:Q96PF2 TSSK2			0.564	2
UniProt:Q9Y463 DYR1B			0.564	2
UniProt:Q8WTQ7 GRK7	1	GRK7 [photoreceptor disc membrane] (R-HSA-6787797)	0.564	2
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [plasma membrane] (R-HSA-432796) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) CAMK2A [cytosol] (R-HSA-4332329) p-T286-CAMK2A [cytosol] (R-HSA-445368)	0.564	3
UniProt:P43250 GRK6	1	GRK6 [plasma membrane] (R-HSA-8852159)	0.564	2
UniProt:Q8NE63 HIPK4			0.564	2
UniProt:P22694 PRKACB	3	PRKACB [ciliary base] (R-HSA-5610404) PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937)	0.564	2
UniProt:P31749 AKT1	13	p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252) AKT1 [plasma membrane] (R-HSA-199416) p-S473-AKT1 [plasma membrane] (R-HSA-377265) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357)	0.564	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.564	2
UniProt:P51813 BMX	3	BMX [cytosol] (R-HSA-351917) BMX(243-675) [cytosol] (R-HSA-351875) BMX(1-242) [cytosol] (R-HSA-351899)	0.564	3
UniProt:O60260 PRKN	3	polyUb-PARK2 [cytosol] (R-HSA-5689094) p-S9-PRKN [cytosol] (R-HSA-9793481) PRKN [cytosol] (R-HSA-201579)	0.564	2
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) p-Y342-PTK6 [cytosol] (R-HSA-8848007) PTK6 [cytosol] (R-HSA-8848000)	0.564	3
UniProt:Q13418 ILK	1	ILK [cytosol] (R-HSA-432864)	0.564	2
UniProt:O14733 MAP2K7	4	MAP2K7(?-419) [cytosol] (R-HSA-5211401) MAP2K7(2-?) [cytosol] (R-HSA-5211389) MAP2K7 [cytosol] (R-HSA-450276) p-S271,T275-MAP2K7 [cytosol] (R-HSA-450353)	0.564	2
UniProt:P30530 AXL	2	p-Y779,Y821-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.564	3
UniProt:P48729 CSNK1A1	2	CSNK1A1 [cytosol] (R-HSA-195263) CSNK1A1 [cilium] (R-HSA-5632507)	0.564	2
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:Q8N7X4 MAGB6			0.556	3
ChEBI:47785 AMP-PNP			0.544	3
ChEBI:16761 ADP			0.544	3
UniProt:Q96A26 F162A			0.543	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.536	2
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506)	0.536	3
UniProt:Q38SD2 LRRK1			0.527	2
UniProt:Q8TDR2 STK35			0.527	2
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.527	2
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.527	2
UniProt:O15146 MUSK	1	MUSK [plasma membrane] (R-HSA-197753)	0.524	2
UniProt:P29317 EPHA2	2	EPHA2 [plasma membrane] (R-HSA-211422) p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380)	0.524	2
UniProt:O75469 NR1I2			0.524	2
UniProt:O94921 CDK14			0.524	2
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.524	2
UniProt:Q9P215 POGK			0.524	2
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.524	2
UniProt:Q96Q40 CDK15			0.524	2
UniProt:Q15303 ERBB4			0.524	2
UniProt:Q8TF76 HASP			0.524	2
UniProt:P29597 TYK2	5	p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.524	2
UniProt:Q16671 AMHR2	1	AMHR2 [plasma membrane] (R-HSA-8858258)	0.524	2
UniProt:P80192 M3K9			0.524	2
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.524	2
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.524	2
UniProt:Q13555 CAMK2G	5	p-T287-CAMK2G [plasma membrane] (R-HSA-432797) p-T287-CAMK2G [endocytic vesicle membrane] (R-HSA-417014) p-T287-CAMK2G [nucleoplasm] (R-HSA-444781) CAMK2G [cytosol] (R-HSA-9611358) p-T287-CAMK2G [cytosol] (R-HSA-445369)	0.524	2
UniProt:Q8TD19 NEK9	3	p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225) p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213)	0.524	2
UniProt:P49758 RGS6	1	RGS6 [plasma membrane] (R-HSA-939789)	0.524	2
UniProt:P36896 ACVR1B	2	ACVR1B [plasma membrane] (R-HSA-205867) p-4S,T188,T206-ACVR1B [plasma membrane] (R-HSA-205780)	0.524	2
UniProt:Q06187 BTK	6	p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) Active BTK [cytosol] (R-HSA-8964323) p-Y551-BTK [cytosol] (R-HSA-2685603) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807)	0.524	2
UniProt:P31751 AKT2	7	p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056) p-T309-AKT2 [cytosol] (R-HSA-202066) AKT2 [cytosol] (R-HSA-49859) AKT2 [plasma membrane] (R-HSA-202053) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087)	0.524	2
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.524	2
UniProt:Q05513 PRKCZ	5	pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cell junction] (R-HSA-2134483) PRKCZ [cytosol] (R-HSA-58218) p-T410-PRKCZ [cytosol] (R-HSA-437181)	0.524	2
UniProt:Q00534 CDK6	3	CDK6 [cytosol] (R-HSA-68336) CDK6 [nucleoplasm] (R-HSA-141283) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.524	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.524	2
UniProt:Q01432 AMPD3	4	AMPD3 [cytosol] (R-HSA-49929) AMPD3 [ficolin-1-rich granule lumen] (R-HSA-6801077) AMPD3 [extracellular region] (R-HSA-6806502) AMPD3 [secretory granule lumen] (R-HSA-6801064)	0.499	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.499	2
UniProt:Q8IWX7 UN45B			0.499	2
UniProt:P04899 GNAI2	1	GNAI2 [plasma membrane] (R-HSA-55435)	0.483	2
UniProt:P19838 NFKB1	8	NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.483	3

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