Reactome | HSP90AB1 [secretory granule lumen]

HSP90AB1 [secretory granule lumen]

Stable Identifier

R-HSA-6801477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Heat shock protein HSP 90-beta, HS90B_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08238 HSP90AB1

Gene Names

HSP90AB1, HSP90B, HSPC2, HSPCB

Chain

initiator methionine:1, chain:2-724

Reference Genes

BioGPS Gene:3326 HSP90AB1

COSMIC (genes):HSP90AB1 HSP90AB1

CTD Gene:3326 HSP90AB1

dbSNP Gene:3326 HSP90AB1

ENSEMBL:ENSG00000096384 HSP90AB1

HGNC:5258 HSP90AB1

KEGG Gene (Homo sapiens):3326 HSP90AB1

Monarch:3326 HSP90AB1

NCBI Gene:3326 HSP90AB1

OMIM:140572 HSP90AB1

UCSC:P08238 HSP90AB1

Reference Transcript

Other Identifiers

0003990687

1161_at

11723417_s_at

1557910_at

17009217

18670460

18670461

18670462

18670463

18670464

200064_PM_at

200064_at

214359_s_at

2719007

2719013

2735193

2735196

2735198

2735199

2735200

2735203

2735204

2735209

2735210

2735211

2735212

2908477

2908481

2908482

2908483

2908485

2908486

2908487

2908488

2908489

2908491

2908492

2908494

2908495

2908497

2908498

2908499

2908500

2908501

2908502

2908503

2908505

2908508

2908509

2908510

2908511

2908512

3326

33984_at

7892509

7892652

7892902

7893138

7893191

7893244

7893264

7893316

7893547

7893650

7893762

7893769

7894012

7894366

7894429

7894672

7894798

7895123

7895328

7895585

7895953

7896022

8119993

A_14_P109676

A_23_P145089

A_24_P170295

GE57843

GO:0000003

GO:0000166

GO:0000902

GO:0001890

GO:0002134

GO:0002135

GO:0002376

GO:0003674

GO:0003723

GO:0003725

GO:0005515

GO:0005524

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005886

GO:0006259

GO:0006457

GO:0006464

GO:0006805

GO:0006810

GO:0006913

GO:0006950

GO:0006986

GO:0007004

GO:0007049

GO:0007165

GO:0008092

GO:0008150

GO:0008180

GO:0008219

GO:0009056

GO:0009058

GO:0009651

GO:0009986

GO:0010033

GO:0015031

GO:0016020

GO:0016192

GO:0016234

GO:0016323

GO:0016324

GO:0016887

GO:0017098

GO:0019062

GO:0019887

GO:0019899

GO:0019900

GO:0019901

GO:0021955

GO:0022607

GO:0022618

GO:0023026

GO:0030010

GO:0030154

GO:0030234

GO:0030235

GO:0030511

GO:0030911

GO:0031072

GO:0031396

GO:0031410

GO:0031526

GO:0031625

GO:0032092

GO:0032435

GO:0032516

GO:0032564

GO:0032991

GO:0033138

GO:0034605

GO:0034641

GO:0034751

GO:0034774

GO:0035590

GO:0038096

GO:0040007

GO:0042220

GO:0042277

GO:0042307

GO:0042470

GO:0042493

GO:0042592

GO:0042802

GO:0042803

GO:0042826

GO:0043008

GO:0043025

GO:0043066

GO:0043167

GO:0043226

GO:0043312

GO:0043524

GO:0044183

GO:0044294

GO:0044295

GO:0044325

GO:0044403

GO:0045296

GO:0045429

GO:0045597

GO:0045793

GO:0046983

GO:0048156

GO:0048471

GO:0048675

GO:0048856

GO:0050821

GO:0051082

GO:0051131

GO:0051248

GO:0051276

GO:0051897

GO:0051973

GO:0060334

GO:0060338

GO:0065003

GO:0070062

GO:0070182

GO:0071157

GO:0071353

GO:0071407

GO:0071902

GO:0097435

GO:0097718

GO:0120293

GO:1900034

GO:1901389

GO:1901799

GO:1902949

GO:1903660

GO:1903827

GO:1904031

GO:1904813

GO:1905323

GO:1990226

GO:1990565

GO:1990913

GO:1990917

GO:2000010

HMNXSV003041712

Hs.74335.1.S1_3p_a_at

Hs2.434250.1.S1_3p_s_at

ILMN_1673711

J04988_at

PH_hs_0028959

PH_hs_0031307

TC06000615.hg

g9082288_3p_at

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

HSP90AB1 [ficolin-1-rich granule lumen]

HSP90AB1 [extracellular region]

HSP90AB1 [cytosol]

HSP90AB1 [nucleoplasm]

HSP90AB1 [lysosomal lumen]

Inferred To

HSP90AB1 [secretory granule lumen] (Canis familiaris)

HSP90AB1 [secretory granule lumen] (Gallus gallus)

HSP90AB1 [secretory granule lumen] (Plasmodium falciparum)

HSP90AB1 [secretory granule lumen] (Sus scrofa)

HSP90AB1 [secretory granule lumen] (Xenopus tropicalis)

HSC82 [secretory granule lumen] (Saccharomyces cerevisiae)

Hsp90ab1 [secretory granule lumen] (Mus musculus)

Hsp90ab1 [secretory granule lumen] (Rattus norvegicus)

hspD [secretory granule lumen] (Dictyostelium discoideum)

daf-21 [secretory granule lumen] (Caenorhabditis elegans)

swo1 [secretory granule lumen] (Schizosaccharomyces pombe)

Hsp83 [secretory granule lumen] (Drosophila melanogaster)

hsp90ab1 [secretory granule lumen] (Danio rerio)

HSP82 [secretory granule lumen] (Saccharomyces cerevisiae)

Homologues of HSP90AB1 [secretory granule lumen] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_031381.2, NP_001258900.1, NP_001258898.1, NP_001258899.1

Guide to Pharmacology - Targets

2907

OpenTargets

ENSG00000096384

ZINC - Substances

HS90B_HUMAN

ZINC - Biogenic

HS90B_HUMAN

ZINC target

P08238

PRO

P08238

GlyGen

P08238

PDB

3PRY, 3FWV, 6N8Y, 5UCJ, 1UYM, 3UQ3, 5FWP, 2L6J, 3NMQ, 1QZ2, 5FWK, 5UCH, 5FWL, 5UC4, 5UCI, 6N8W, 5FWM

ZINC - Investigational

HS90B_HUMAN

GeneCards

P08238

HPA

ENSG00000096384-HSP90AB1

Ensembl

ENSP00000360609, ENST00000371646, ENST00000371554, ENSP00000481908, ENSP00000360709, ENSG00000096384, ENST00000620073, ENST00000353801, ENSP00000325875

Pharos - Targets

P08238

ZINC - Predictions - Purchasable

HS90B_HUMAN

Interactors (124)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.89	10
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.889	11
UniProt:Q13451 FKBP5	2	FKBP5 [cytosol] (R-HSA-5618096) FKBP5 [nucleoplasm] (R-HSA-8939165)	0.849	16
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.832	11
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.829	8
UniProt:P53041 PPP5C	2	PPP5C [nucleoplasm] (R-HSA-5683410) PPP5C [cytosol] (R-HSA-5675402)	0.827	7
UniProt:Q9UHD1 CHRD1			0.801	6
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-8939162) FKBP4 [cytosol] (R-HSA-5618108) FKBP4 [nucleoplasm] (R-HSA-5324621)	0.793	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.788	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491)	0.761	4
UniProt:P04049 RAF1	20	p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) RAF1 [cytosol] (R-HSA-167205) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115)	0.758	5
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646)	0.757	8
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.744	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.743	5
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [platelet dense granule lumen] (R-HSA-8848903) CDC37L1 [extracellular region] (R-HSA-8848918)	0.743	5
UniProt:P04626 ERBB2	20	p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) ERBB2 G309E [plasma membrane] (R-HSA-9665342) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) ERBB2 G309A [plasma membrane] (R-HSA-9665349)	0.734	4
UniProt:P11802 CDK4	3	CDK4 [cytosol] (R-HSA-68330) p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [nucleoplasm] (R-HSA-113843)	0.723	4
UniProt:Q96GD4 AURKB	3	SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231) AURKB [nucleoplasm] (R-HSA-4655360)	0.723	4
UniProt:O95433 AHSA1			0.702	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.688	4
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) p-T559-MAP3K14 [cytosol] (R-HSA-5668531) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525)	0.688	5
UniProt:O95801 TTC4			0.682	5
UniProt:P15056 BRAF	20	BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF E501G [cytosol] (R-HSA-9651132) BRAF-MACF1fusion [cytosol] (R-HSA-6802402) BRAF D594N [cytosol] (R-HSA-6802299) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L505H [cytosol] (R-HSA-9648845) BRAF D594G [cytosol] (R-HSA-6802295) BRAF E586K [cytosol] (R-HSA-6802308) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF N581D [cytosol] (R-HSA-9651152) BRAF G464E [cytosol] (R-HSA-6802369) BRAF L597V [cytosol] (R-HSA-6802397) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469V [cytosol] (R-HSA-9648620) BRAF D638E [cytosol] (R-HSA-9651125) BRAF A246P [cytosol] (R-HSA-9651123) BRAF V600K [cytosol] (R-HSA-6802502) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305)	0.669	4
UniProt:Q15418 RPS6KA1	7	RPS6KA1 [nucleoplasm] (R-HSA-199860) p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [cytosol] (R-HSA-444256) p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol] (R-HSA-9619871) p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm] (R-HSA-444292) p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol] (R-HSA-9619993) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957)	0.669	4
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG [nucleoplasm] (R-HSA-4755413) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG E391* [cytosol] (R-HSA-5262924) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG R173G [cytosol] (R-HSA-5262966)	0.669	4
UniProt:P41279 MAP3K8	4	p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259) p-S400-MAP3K8 [cytosol] (R-HSA-5684308) MAP3K8 [cytosol] (R-HSA-389388) p-S400-MAP3K8 [cytosol] (R-HSA-389738)	0.656	3
UniProt:O14757 CHEK1	3	p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838) CHEK1 [cytosol] (R-HSA-205285) CHEK1 [nucleoplasm] (R-HSA-113826)	0.656	3
UniProt:P49840 GSK3A	3	GSK3A [cytosol] (R-HSA-198326) p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490)	0.646	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [lysosomal lumen] (R-HSA-9622850) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [nucleoplasm] (R-HSA-5082401)	0.643	9
UniProt:P06241 FYN	6	MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) p-Y531-FYN [cytosol] (R-HSA-391819) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873)	0.641	4
UniProt:Q13618 CUL3	3	CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.641	3
UniProt:P09769 FGR	3	FGR [extracellular region] (R-HSA-6806524) FGR [secretory granule lumen] (R-HSA-6804974) FGR [cytosol] (R-HSA-432116)	0.641	4
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.641	4
UniProt:Q2WGJ6 KLH38			0.641	3
UniProt:P06239 LCK	4	p-Y394-LCK [cytosol] (R-HSA-202308) p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) LCK [cytosol] (R-HSA-167609)	0.641	4
UniProt:Q15831 STK11	2	STK11 [cytosol] (R-HSA-380954) STK11 [nucleoplasm] (R-HSA-164119)	0.641	4
UniProt:P21333 FLNA	3	FLNA [extracellular region] (R-HSA-350712) FLNA [cytosol] (R-HSA-210019) p-S2152-FLNA [cytosol] (R-HSA-5669246)	0.615	3
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-450290) p-TBK1 [cytosol] (R-HSA-9008705) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.589	3
UniProt:Q13546 RIPK1	14	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) RIPK1 D324N [cytosol] (R-HSA-9693930) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) RIPK1 [endosome membrane] (R-HSA-450326) RIPK1 D324H [cytosol] (R-HSA-9693922) RIPK1 D324V [cytosol] (R-HSA-9693927) RIPK1 D324Y [cytosol] (R-HSA-9693931) RIPK1 [plasma membrane] (R-HSA-937073) RIPK1(325-671) [cytosol] (R-HSA-5212671) p-S166-RIPK1 [cytosol] (R-HSA-5218872) K63polyUb-RIPK1 [cytosol] (R-HSA-937021) RIPK1 [cytosol] (R-HSA-168651)	0.589	2
UniProt:Q14164 IKBKE	4	p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278)	0.589	3
UniProt:Q9H1R3 MYLK2			0.564	3
UniProt:Q9BXA6 TSSK6			0.564	3
UniProt:P08631 HCK	2	HCK [cytosol] (R-HSA-167708) p-HCK [cytosol] (R-HSA-9676060)	0.564	3
UniProt:P51813 BMX	3	BMX(1-242) [cytosol] (R-HSA-351899) BMX(243-675) [cytosol] (R-HSA-351875) BMX [cytosol] (R-HSA-351917)	0.564	3
UniProt:P51812 RPS6KA3	7	RPS6KA3 [cytosol] (R-HSA-444250) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [nucleoplasm] (R-HSA-444286) p-4S,T231,T365-RPS6KA3 [nucleoplasm] (R-HSA-199830) p-S227,T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619872) p-T365,S369,S386,T577,T737-RPS6KA3 [cytosol] (R-HSA-9619989) RPS6KA3 [nucleoplasm] (R-HSA-199869) p-T365,S369,T577-RPS6KA3 [cytosol] (R-HSA-9619959)	0.564	3
UniProt:Q08881 ITK	3	ITK [cytosol] (R-HSA-202319) p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616)	0.564	2
UniProt:Q07912 ACK1			0.564	3
UniProt:P07948 LYN	7	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) p-Y396-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [plasma membrane] (R-HSA-197943) MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) p-Y397-LYN [cytosol] (R-HSA-8942608)	0.564	2
UniProt:P07947 YES1	2	MyrG-p-Y426-YES1 [plasma membrane] (R-HSA-1810411) YES1 [cytosol] (R-HSA-373640)	0.564	3
UniProt:P05129 PRKCG	1	PRKCG [cytosol] (R-HSA-58204)	0.564	2
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.564	2
UniProt:Q13131 PRKAA1	3	p-T183-PRKAA1 [cytosol] (R-HSA-380964) PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206)	0.564	2
UniProt:P11362 FGFR1	8	FGFR1 N546K [plasma membrane] (R-HSA-1614377) p-8Y-FGFR1 N546K [plasma membrane] (R-HSA-2023358) FGFR1 R576W [plasma membrane] (R-HSA-2011844) p-8Y- FGFR1 R576W [plasma membrane] (R-HSA-2023361) FGFR1 K656E [plasma membrane] (R-HSA-1614373) p-6Y FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853142) p-8Y-FGFR1 K656E [plasma membrane] (R-HSA-2023356) FGFR1(22-763):TACC1(571-805) fusion [plasma membrane] (R-HSA-8853241)	0.564	2
UniProt:Q92918 M4K1			0.564	3
UniProt:Q13619 CUL4A	2	G76-NEDD8-K705-CUL4A [nucleoplasm] (R-HSA-8952514) CUL4A [nucleoplasm] (R-HSA-976006)	0.564	2
UniProt:Q13617 CUL2	3	G76-NEDD8-K689-CUL2 [cytosol] (R-HSA-8952511) CUL2 [cytosol] (R-HSA-416982) CUL2 [nucleoplasm] (R-HSA-1234126)	0.564	2
UniProt:Q96QS6 KPSH2			0.564	2
UniProt:O75426 FBX24			0.564	2
UniProt:Q9UKC9 FBXL2			0.564	2
UniProt:O60260 PRKN	2	PARK2 [cytosol] (R-HSA-201579) polyUb-PARK2 [cytosol] (R-HSA-5689094)	0.564	2
UniProt:P21860 ERBB3			0.564	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.564	2
UniProt:Q13620 CUL4B	2	G76-NEDD8-K859-CUL4B [nucleoplasm] (R-HSA-8952522) CUL4B [nucleoplasm] (R-HSA-975973)	0.564	2
UniProt:Q00526 CDK3			0.564	2
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.564	3
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.564	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [cytosol] (R-HSA-210616) EIF2C1 [nucleoplasm] (R-HSA-5578686)	0.564	3
UniProt:Q8N165 PDK1L			0.564	2
UniProt:Q9UQM7 CAMK2A	6	p-T286-CAMK2A [endocytic vesicle membrane] (R-HSA-416999) p-T286-CAMK2A [cytosol] (R-HSA-445368) p-T286-CAMK2A [nucleoplasm] (R-HSA-444797) p-T286,T305,T306-CAMK2A [cytosol] (R-HSA-4332334) p-T286-CAMK2A [plasma membrane] (R-HSA-432796) CAMK2A [cytosol] (R-HSA-4332329)	0.564	3
UniProt:Q86YV6 MYLK4			0.564	2
UniProt:P22694 PRKACB	3	PRKACB [cytosol] (R-HSA-57846) PRKACB [nucleoplasm] (R-HSA-111937) PRKACB [ciliary base] (R-HSA-5610404)	0.564	2
UniProt:Q13882 PTK6	5	p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007) p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y351-PTK6 [cytosol] (R-HSA-8857570)	0.564	3
UniProt:Q13616 CUL1	3	CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519) CUL1 [cytosol] (R-HSA-174230)	0.564	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.564	2
UniProt:P30530 AXL	2	p-Y772,Y814-AXL [plasma membrane] (R-HSA-5357460) AXL [plasma membrane] (R-HSA-197705)	0.564	3
UniProt:P31749 AKT1	13	AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-T308-AKT1 [cytosol] (R-HSA-198634) AKT1 [cytosol] (R-HSA-58252)	0.564	3
UniProt:Q8N7X4 MAGB6			0.556	3
ChEBI:47785 AMP-PNP			0.544	3
ChEBI:16761 ADP			0.544	3
UniProt:Q96A26 F162A			0.543	3
UniProt:O14920 IKBKB	3	IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB [cytosol] (R-HSA-168114)	0.536	3
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [cytosol] (R-HSA-66370)	0.536	2
UniProt:P35579 MYH9	3	MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y ALK(1067-1620) fusion [cytosol] (R-HSA-9715279) MYH9 [cytosol] (R-HSA-419173)	0.527	2
UniProt:P13569 CFTR	17	CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR [plasma membrane] (R-HSA-383188) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR [endosome membrane] (R-HSA-6782965) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) CFTR N1303K [plasma membrane] (R-HSA-5678983) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) ub-CFTR F508del [cytosol] (R-HSA-8866838) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	11
UniProt:P36896 ACVR1B	2	ACVR1B [plasma membrane] (R-HSA-205867) p-4S,T188,T206-ACVR1B [plasma membrane] (R-HSA-205780)	0.524	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181)	0.524	2
UniProt:O15146 MUSK	1	MUSK [plasma membrane] (R-HSA-197753)	0.524	2
UniProt:P29317 EPHA2	3	EPHA2 [plasma membrane] (R-HSA-2682326) EPHA2 [plasma membrane] (R-HSA-211422) p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380)	0.524	2
UniProt:P51817 PRKX	1	PRKX [nucleoplasm] (R-HSA-3222308)	0.524	2
UniProt:O75469 NR1I2			0.524	2
UniProt:Q15208 STK38	1	STK38 [cytosol] (R-HSA-9715143)	0.524	2
UniProt:O94921 CDK14			0.524	2
UniProt:P53671 LIMK2	2	p-T505-LIMK2 [cytosol] (R-HSA-419711) LIMK2 [cytosol] (R-HSA-419171)	0.524	2
UniProt:Q9P215 POGK			0.524	2
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.524	2
UniProt:P31751 AKT2	8	p-T309,S474-AKT2 [cytosol] (R-HSA-202062) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) p-T309-AKT2 [cytosol] (R-HSA-202066) p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087) AKT2 [plasma membrane] (R-HSA-202053) p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056) AKT2 [cytosol] (R-HSA-49859) p-T309,S474-AKT2 [cytosol] (R-HSA-166800)	0.524	2
UniProt:P11801 KPSH1			0.524	2
UniProt:Q96Q40 CDK15			0.524	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.524	2
UniProt:Q15303 ERBB4			0.524	2
UniProt:P22607 FGFR3	20	FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 S371C [plasma membrane] (R-HSA-1614421) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) FGFR3 K650T [plasma membrane] (R-HSA-1614411) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) pY-FGFR3 [plasma membrane] (R-HSA-2038368) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) FGFR3 [plasma membrane] (R-HSA-2038357)	0.524	2
UniProt:Q96S53 TESK2			0.524	2
UniProt:Q8TF76 HASP			0.524	2
UniProt:Q15131 CDK10			0.524	2
UniProt:P29597 TYK2	5	p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-TYK2 [cytosol] (R-HSA-8950424) TYK2 [cytosol] (R-HSA-877348) p-Y1054-TYK2 [cytosol] (R-HSA-1112598) p-Y-TYK2 [cytosol] (R-HSA-6784366)	0.524	2
UniProt:Q16671 AMHR2	1	AMHR2 [plasma membrane] (R-HSA-8858258)	0.524	2
UniProt:P80192 M3K9			0.524	2
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.524	2
UniProt:Q01974 ROR2	2	ROR2 [plasma membrane] (R-HSA-197731) ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729)	0.524	2
UniProt:Q9UPZ9 CILK1			0.524	2
UniProt:Q13555 CAMK2G	5	p-T287-CAMK2G [nucleoplasm] (R-HSA-444781) p-T287-CAMK2G [cytosol] (R-HSA-445369) p-T287-CAMK2G [plasma membrane] (R-HSA-432797) p-T287-CAMK2G [endocytic vesicle membrane] (R-HSA-417014) CAMK2G [cytosol] (R-HSA-9611358)	0.524	2
UniProt:P31152 MAPK4	4	MAPK4 [cytosol] (R-HSA-5686973) p-S186 MAPK4 [nucleoplasm] (R-HSA-5687022) p-S186 MAPK4 [cytosol] (R-HSA-5687023) MAPK4 [nucleoplasm] (R-HSA-5686975)	0.524	2
UniProt:P35916 FLT4	1	FLT4 [plasma membrane] (R-HSA-195359)	0.524	2
UniProt:Q8TD19 NEK9	3	p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213) p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225)	0.524	2
UniProt:Q16832 DDR2	1	DDR2 [plasma membrane] (R-HSA-211419)	0.524	2
UniProt:P49758 RGS6	1	RGS6 [plasma membrane] (R-HSA-939789)	0.524	2
UniProt:Q9UM73 ALK	20	p-7Y ALK T1087I [plasma membrane] (R-HSA-9723885) p-7Y ALK M1166N [plasma membrane] (R-HSA-9723299) p-7Y ALK R1061Q [plasma membrane] (R-HSA-9723884) p-7Y ALK M1166T [plasma membrane] (R-HSA-9700486) p-7Y ALK Y1239H [plasma membrane] (R-HSA-9715290) p-7Y ALK I1171T [plasma membrane] (R-HSA-9700489) p-7Y ALK R1275L [plasma membrane] (R-HSA-9699800) p-7Y ALK F1174C [plasma membrane] (R-HSA-9699821) p-7Y ALK F1174V [plasma membrane] (R-HSA-9699921) p-7Y ALK E1384K [plasma membrane] (R-HSA-9715285) p-7Y ALK L1196Q [plasma membrane] (R-HSA-9700476) p-7Y ALK V1180L [plasma membrane] (R-HSA-9715289) p-7Y ALK G1201R [plasma membrane] (R-HSA-9701860) p-7Y ALK L1196M [plasma membrane] (R-HSA-9700464) p-7Y ALK R1275* [plasma membrane] (R-HSA-9699915) p-7Y ALK M1166R [plasma membrane] (R-HSA-9700477) p-Y ALK S1206C [plasma membrane] (R-HSA-9715292) p-7Y ALK I1171S [plasma membrane] (R-HSA-9714063) p- 7Y ALK L1122V [plasma membrane] (R-HSA-9715294) p-7Y ALK G1128S [plasma membrane] (R-HSA-9700462)	0.524	2
UniProt:Q00534 CDK6	3	CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.524	2
UniProt:Q06187 BTK	6	Active BTK [cytosol] (R-HSA-8964323) p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y551-BTK [cytosol] (R-HSA-2685603) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) BTK [cytosol] (R-HSA-197948)	0.524	2
UniProt:Q01432 AMPD3	4	AMPD3 [cytosol] (R-HSA-49929) AMPD3 [secretory granule lumen] (R-HSA-6801064) AMPD3 [extracellular region] (R-HSA-6806502) AMPD3 [ficolin-1-rich granule lumen] (R-HSA-6801077)	0.499	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.499	2
UniProt:Q8IWX7 UN45B			0.499	2
UniProt:P04899 GNAI2	1	GNAI2 [plasma membrane] (R-HSA-55435)	0.483	2
UniProt:P19838 NFKB1	8	NFKB1(1-968) [cytosol] (R-HSA-451607) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-433) [cytosol] (R-HSA-168168)	0.483	3

Cite Us!