Reactome | HSP90AB1 [secretory granule lumen]

HSP90AB1 [secretory granule lumen]

Stable Identifier

R-HSA-6801477

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

Heat shock protein HSP 90-beta, HS90B_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P08238 HSP90AB1

Gene Names

HSP90AB1, HSP90B, HSPC2, HSPCB

Chain

initiator methionine:1, chain:2-724

Reference Genes

BioGPS Gene:3326 HSP90AB1

COSMIC (genes):HSP90AB1 HSP90AB1

CTD Gene:3326 HSP90AB1

dbSNP Gene:3326 HSP90AB1

ENSEMBL:ENSG00000096384 HSP90AB1

HGNC:5258 HSP90AB1

KEGG Gene (Homo sapiens):3326 HSP90AB1

Monarch:3326 HSP90AB1

NCBI Gene:3326 HSP90AB1

OMIM:140572 HSP90AB1

UCSC:P08238 HSP90AB1

Reference Transcript

Other Identifiers

0003990687

1161_at

11723417_s_at

1557910_at

17009217

18670460

18670461

18670462

18670463

18670464

1QZ2

1UYM

200064_at

200064_PM_at

214359_s_at

2719007

2719013

2735193

2735196

2735198

2735199

2735200

2735203

2735204

2735209

2735210

2735211

2735212

2908477

2908481

2908482

2908483

2908485

2908486

2908487

2908488

2908489

2908491

2908492

2908494

2908495

2908497

2908498

2908499

2908500

2908501

2908502

2908503

2908505

2908508

2908509

2908510

2908511

2908512

2L6J

3326

33984_at

3FWV

3NMQ

3PRY

3UQ3

5230

55729

5FWK

5FWL

5FWM

5FWP

5UC4

5UCH

5UCI

5UCJ

72606

74351

7892509

7892652

7892902

7893138

7893191

7893244

7893264

7893316

7893547

7893650

7893762

7893769

7894012

7894366

7894429

7894672

7894798

7895123

7895328

7895585

7895953

7896022

8119993

A0A024RD80

A_14_P109676

A_23_P145089

A_24_P170295

AAA36025

AAA36026

AAD14062

AAF82792

AAH04928

AAH09206

AAH12807

AAH14485

AAH16753

AAH68474

AAQ63401

ABC40731

AF275719

AH007358

AK312255

AL136543

AL139392

AY359878

BAG35187

BC004928

BC009206

BC012807

BC014485

BC016753

BC068474

CAB005230

CAB66478

CCDS4909

CH471081

DQ314872

EAX04257

EAX04258

EAX04260

ENSG00000096384

ENSP00000325875

ENSP00000360609

ENSP00000360709

ENSP00000481908

ENST00000353801

ENST00000353801.7

ENST00000371554

ENST00000371554.2

ENST00000371646

ENST00000371646.9

ENST00000620073

ENST00000620073.4

EntrezGene:3326

EntrezGene:HSP90AB1

g9082288_3p_at

GE57843

GO:0000003

GO:0000166

GO:0000902

GO:0001890

GO:0002134

GO:0002135

GO:0002376

GO:0003674

GO:0003723

GO:0003725

GO:0005515

GO:0005524

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005773

GO:0005829

GO:0005886

GO:0006259

GO:0006457

GO:0006464

GO:0006805

GO:0006810

GO:0006950

GO:0006986

GO:0007004

GO:0007049

GO:0007165

GO:0008092

GO:0008144

GO:0008150

GO:0008180

GO:0008219

GO:0009056

GO:0009058

GO:0009651

GO:0009986

GO:0010033

GO:0016020

GO:0016192

GO:0016234

GO:0016323

GO:0016324

GO:0016887

GO:0017098

GO:0019062

GO:0019887

GO:0019899

GO:0019900

GO:0019901

GO:0021955

GO:0022607

GO:0022618

GO:0023026

GO:0030010

GO:0030154

GO:0030234

GO:0030235

GO:0030511

GO:0030911

GO:0031072

GO:0031396

GO:0031410

GO:0031526

GO:0031625

GO:0032092

GO:0032435

GO:0032516

GO:0032564

GO:0032991

GO:0033138

GO:0034605

GO:0034641

GO:0034751

GO:0034774

GO:0035690

GO:0038096

GO:0040007

GO:0042220

GO:0042277

GO:0042470

GO:0042493

GO:0042592

GO:0042623

GO:0042802

GO:0042803

GO:0042826

GO:0043008

GO:0043025

GO:0043066

GO:0043167

GO:0043226

GO:0043312

GO:0043524

GO:0044183

GO:0044294

GO:0044295

GO:0044325

GO:0044403

GO:0045296

GO:0045429

GO:0045597

GO:0045793

GO:0046983

GO:0048156

GO:0048471

GO:0048675

GO:0048856

GO:0050821

GO:0051082

GO:0051131

GO:0051248

GO:0051276

GO:0051897

GO:0051973

GO:0060334

GO:0060338

GO:0065003

GO:0070062

GO:0070182

GO:0071157

GO:0071353

GO:0071407

GO:0071902

GO:0097435

GO:0097718

GO:1900034

GO:1901389

GO:1901799

GO:1902949

GO:1903660

GO:1903827

GO:1904031

GO:1904813

GO:1905323

GO:1990226

GO:1990565

GO:1990913

GO:1990917

GO:2000010

HGNC:5258

HPA055729

HPA072606

HPA074351

Hs.74335.1.S1_3p_a_at

Hs2.434250.1.S1_3p_s_at

HSP90AB1

HSP90AB1-201

HSP90AB1-202

HSP90AB1-203

HSP90AB1-204

ILMN_1673711

IPR001404

IPR003594

IPR019805

IPR020568

IPR020575

IPR036890

IPR037196

J04988

J04988_at

M16660

MIM:140572

NM_001271969

NM_001271970

NM_001271971

NM_001271972

NM_007355

NP_001258898

NP_001258899

NP_001258900

NP_001258901

NP_031381

PF00183

PF02518

PH_hs_0028959

PH_hs_0031307

PR00775

SM00387

TC06000615.hg

UPI00001411EF

XM_024446421

XP_024302189

Participant Of

hasMember

Secretory granule lumen proteins [secretory granule lumen]

Other forms of this molecule

HSP90AB1 [extracellular region]

HSP90AB1 [ficolin-1-rich granule lumen]

HSP90AB1 [lysosomal lumen]

HSP90AB1 [nucleoplasm]

HSP90AB1 [cytosol]

Inferred To

HSP90AB1 [secretory granule lumen] (Bos taurus)

HSP90AB1 [secretory granule lumen] (Caenorhabditis elegans)

HSP90AB1 [secretory granule lumen] (Canis familiaris)

HSP90AB1 [secretory granule lumen] (Dictyostelium discoideum)

HSP90AB1 [secretory granule lumen] (Drosophila melanogaster)

HSP90AB1 [secretory granule lumen] (Mus musculus)

HSP90AB1 [secretory granule lumen] (Plasmodium falciparum)

HSP90AB1 [secretory granule lumen] (Rattus norvegicus)

HSP90AB1 [secretory granule lumen] (Saccharomyces cerevisiae)

HSP90AB1 [secretory granule lumen] (Schizosaccharomyces pombe)

HSP90AB1 [secretory granule lumen] (Sus scrofa)

HSP90AB1 [secretory granule lumen] (Xenopus tropicalis)

Homologues of HSP90AB1 [secretory granule lumen] (Bos taurus)

Cross References

ZINC - Investigational

HS90B_HUMAN

RefSeq

NP_031381.2, NP_001258899.1, NP_001258900.1, NP_001258898.1

OpenTargets

ENSG00000096384

GeneCards

P08238

ZINC - Substances

HS90B_HUMAN

ZINC target

P08238

ZINC - Biogenic

HS90B_HUMAN

PRO

P08238

ZINC - Predictions - Purchasable

HS90B_HUMAN

PDB

5FWM, 2L6J, 5FWL, 5UCH, 1QZ2, 3NMQ, 5FWK, 6N8W, 5UC4, 5UCI, 6N8Y, 3UQ3, 3FWV, 5UCJ, 3PRY, 5FWP, 1UYM

Interactors (102)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.889	11
UniProt:Q13451 FKBP5	2	FKBP5 [nucleoplasm] (R-HSA-8939165) FKBP5 [cytosol] (R-HSA-5618096)	0.849	16
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.839	8
UniProt:P10636-8 MAPT	2	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521)	0.832	11
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.832	7
UniProt:O00170 AIP	2	AIP [cytosol] (R-HSA-8936839) AIP [nucleoplasm] (R-HSA-8937156)	0.829	8
UniProt:Q02790 FKBP4	3	FKBP4 [nucleoplasm] (R-HSA-5324621) FKBP4 [cytosol] (R-HSA-5618108) FKBP4 [nucleoplasm] (R-HSA-8939162)	0.793	6
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.788	7
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [lysosomal lumen] (R-HSA-9622846) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [cytosol] (R-HSA-419617)	0.761	4
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.744	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.743	5
UniProt:Q7L3B6 CDC37L1	2	CDC37L1 [platelet dense granule lumen] (R-HSA-8848903) CDC37L1 [extracellular region] (R-HSA-8848918)	0.743	5
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.734	4
UniProt:P11802 CDK4	3	CDK4 [nucleoplasm] (R-HSA-113843) p-T172-CDK4 [nucleoplasm] (R-HSA-113830) CDK4 [cytosol] (R-HSA-68330)	0.723	4
UniProt:Q96GD4 AURKB	3	AURKB [nucleoplasm] (R-HSA-4655360) SUMO2,3-K202-AURKB [cytosol] (R-HSA-4655414) AURKB [cytosol] (R-HSA-174231)	0.723	4
UniProt:O95433 AHSA1			0.702	4
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S576 ARAF [plasma membrane] (R-HSA-5672648) p-S299,S302,T452,T455,S576 ARAF [cytosol] (R-HSA-5672646) p-S576 ARAF [cytosol] (R-HSA-5672681) p-S214,S576 ARAF [cytosol] (R-HSA-5672639)	0.688	6
UniProt:P04049 RAF1	10	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) RAF1 [cytosol] (R-HSA-167205) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S259,S621-RAF1 [cytosol] (R-HSA-109786) p-S621-RAF1 [plasma membrane] (R-HSA-206222) hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5675420) p-S621-RAF1 [cytosol] (R-HSA-206028) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) p-S338,Y341,T491,S494,S621 RAF1 [cytosol] (R-HSA-5672664)	0.688	3
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.688	4
UniProt:O95801 TTC4			0.682	5
UniProt:Q9Y6K9 IKBKG	12	IKBKG [nucleoplasm] (R-HSA-4755413) SUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wro447 [cytosol] (R-HSA-5262978) IKBKG [cytosol] (R-HSA-168108) K63polyUb-NEMO [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397)	0.669	4
UniProt:P21333 FLNA	3	p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [cytosol] (R-HSA-210019) FLNA [extracellular region] (R-HSA-350712)	0.669	3
UniProt:Q9UHD1 CHRD1			0.659	3
UniProt:P41279 MAP3K8	4	MAP3K8 [cytosol] (R-HSA-389388) p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259) p-S400-MAP3K8 [cytosol] (R-HSA-5684308) p-S400-MAP3K8 [cytosol] (R-HSA-389738)	0.656	3
UniProt:O14757 CHEK1	3	CHEK1 [nucleoplasm] (R-HSA-113826) CHEK1 [cytosol] (R-HSA-205285) p-S317,S345-CHEK1 [nucleoplasm] (R-HSA-113838)	0.656	3
UniProt:P07900 HSP90AA1	8	HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.643	9
UniProt:Q2WGJ6 KLH38			0.641	3
UniProt:Q15831 STK11	2	STK11 [nucleoplasm] (R-HSA-164119) STK11 [cytosol] (R-HSA-380954)	0.641	4
UniProt:Q13546 RIPK1	9	PolyUb-RIPK1 [cytosol] (R-HSA-6783197) K48polyUb-RIPK1 [cytosol] (R-HSA-6783308) K63pUb-K377-RIP1 [cytosol] (R-HSA-5212672) RIPK1(1-324) [cytosol] (R-HSA-5212664) p-S-RIPK1 [cytosol] (R-HSA-5218872) RIPK1 [cytosol] (R-HSA-168651) RIPK1(325-671) [cytosol] (R-HSA-5212671) RIPK1 [endosome membrane] (R-HSA-450326) K63polyUb-RIPK1 [cytosol] (R-HSA-937021)	0.589	2
UniProt:Q9UHD2 TBK1	6	p-S172-TBK1 [endosome membrane] (R-HSA-450290) p-S172-TBK1 [plasma membrane] (R-HSA-936983) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397) TBK1 [cytosol] (R-HSA-166267) p-S172-TBK1 [cytosol] (R-HSA-168379)	0.589	3
UniProt:Q14164 IKBKE	5	p-S172-IKBKE [endosome membrane] (R-HSA-450278) IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [plasma membrane] (R-HSA-936973) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) SUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	3
UniProt:Q12933 TRAF2	5	K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) TRAF2 [cytosol] (R-HSA-66370) PolyUb-TRAF2 [cytosol] (R-HSA-6782848)	0.589	2
UniProt:O14920 IKBKB	3	IKBKB [cytosol] (R-HSA-168114) p-S177,S181-IKBKB [cytosol] (R-HSA-202506) IKBKB Q432Pfs*62 [cytosol] (R-HSA-9628518)	0.589	3
UniProt:Q99558 MAP3K14	5	K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531) p-MAP3K14 [cytosol] (R-HSA-168187) MAP3K14 [cytosol] (R-HSA-168189) Active NIK [cytosol] (R-HSA-5607646)	0.589	3
UniProt:P04899 GNAI2	1	GNAI2 [plasma membrane] (R-HSA-55435)	0.564	2
UniProt:Q9BXA6 TSSK6			0.564	3
UniProt:Q08881 ITK	3	p-Y512-ITK [cytosol] (R-HSA-422519) p-Y180,Y512-ITK [cytosol] (R-HSA-2685616) ITK [cytosol] (R-HSA-202319)	0.564	2
UniProt:Q15418 RPS6KA1	7	p-4S,T359,T573-RPS6KA1 [nucleoplasm] (R-HSA-199829) RPS6KA1 [nucleoplasm] (R-HSA-199860) RPS6KA1 [cytosol] (R-HSA-444256) p-T359,S363,T573-RPS6KA1 [cytosol] (R-HSA-9619957) p-S221,T459,S363,S380,T573,T732-RPS6KA1 [cytosol] (R-HSA-9619871) p-T359,S363,S380.T573,T372-RPS6KA1 [cytosol] (R-HSA-9619993) p-S221,T359,S363,S380,T573,T732-RPS6KA1 [nucleoplasm] (R-HSA-444292)	0.564	2
UniProt:Q9UKT8 FBXW2	1	FBXW2 [cytosol] (R-HSA-391300)	0.564	2
UniProt:Q13131 PRKAA1	3	PRKAA1 [cytosol] (R-HSA-380935) p-T183-PRKAA1 [nucleoplasm] (R-HSA-2151206) p-T183-PRKAA1 [cytosol] (R-HSA-380964)	0.564	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.564	2
UniProt:Q96QS6 KPSH2			0.564	2
UniProt:O75426 FBX24			0.564	2
UniProt:Q9UKC9 FBXL2			0.564	2
UniProt:O60260 PRKN	2	polyUb-PARK2 [cytosol] (R-HSA-5689094) PARK2 [cytosol] (R-HSA-201579)	0.564	2
UniProt:P21860 ERBB3			0.564	3
UniProt:Q00526 CDK3			0.564	2
UniProt:P50613 CDK7	1	CDK7 [nucleoplasm] (R-HSA-69218)	0.564	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [cytosol] (R-HSA-210616) EIF2C1 [nucleoplasm] (R-HSA-5578686)	0.564	3
UniProt:Q8N165 PDK1L			0.564	2
UniProt:Q86YV6 MYLK4			0.564	2
UniProt:P22694 PRKACB	3	PRKACB [cytosol] (R-HSA-57846) PRKACB [ciliary base] (R-HSA-5610404) PRKACB [nucleoplasm] (R-HSA-111937)	0.564	2
UniProt:P19838 NFKB1	8	p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004)	0.564	3
UniProt:P15056 BRAF	68	BRAF-MACF1fusion [cytosol] (R-HSA-6802402) p-S,T-BRAF [cytosol] (R-HSA-169856) p-BRAF-MACF1 fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620) BRAF T244P [cytosol] (R-HSA-9651165) BRAF G469R [cytosol] (R-HSA-9648621) BRAF L597R [cytosol] (R-HSA-9648617) BRAF G469E [cytosol] (R-HSA-9648618) BRAF L597Q [cytosol] (R-HSA-9648619) BRAF G466A [cytosol] (R-HSA-9648613) BRAF G466V [cytosol] (R-HSA-9648838) BRAF N581S [cytosol] (R-HSA-9648850) BRAF G464V [cytosol] (R-HSA-9648611) p-BRAF L597V [plasma membrane] (R-HSA-8936647) p-BRAF L505H [plasma membrane] (R-HSA-9648862) p-BRAF G464E [plasma membrane] (R-HSA-8936645) p-BRAF F595L [plasma membrane] (R-HSA-8936641) p-BRAF A246P [plasma membrane] (R-HSA-9651188) p-BRAF E586K [plasma membrane] (R-HSA-8936639) p-BRAF N581D [plasma membrane] (R-HSA-9651191) p-BRAF V600K [plasma membrane] (R-HSA-8936651) p-BRAF G464V [plasma membrane] (R-HSA-9648633) p-BRAF T244P [plasma membrane] (R-HSA-9651194) p-BRAF G469E [plasma membrane] (R-HSA-9648634) p-BRAF G466V [plasma membrane] (R-HSA-9648859) p-BRAF G469V [plasma membrane] (R-HSA-9648628) p-BRAF G466A [plasma membrane] (R-HSA-9648629) p-BRAF L597Q [plasma membrane] (R-HSA-9648630) p-BRAF L597R [plasma membrane] (R-HSA-9648631) p-BRAF N581S [plasma membrane] (R-HSA-9648866) p-BRAF G469R [plasma membrane] (R-HSA-9648627) BRAF 599dupT [cytosol] (R-HSA-6802281) BRAF G534R [cytosol] (R-HSA-9651134) BRAF S467A [cytosol] (R-HSA-9651161) BRAF K601N [cytosol] (R-HSA-9648857) BRAF G469A [cytosol] (R-HSA-6802381) BRAF L485F [cytosol] (R-HSA-9651147) BRAF Q257R [cytosol] (R-HSA-9651157) BRAF K499E [cytosol] (R-HSA-9651142) BRAF V600E [cytosol] (R-HSA-6802498) BRAF K601E [cytosol] (R-HSA-9648833) BRAF V600E V169_M438del [cytosol] (R-HSA-6802489) BRAF V600E V47_D380del [cytosol] (R-HSA-6802491) BRAF V600E V47_M438del [cytosol] (R-HSA-6802495) V600E BRAF V169_D380del [cytosol] (R-HSA-6802486) p-S445,S729-BRAF [plasma membrane] (R-HSA-8933622) BRAF [cytosol] (R-HSA-167224) p-S365,S445,S729 BRAF [cytosol] (R-HSA-5672667) hyperphosphorylated BRAF [plasma membrane] (R-HSA-5675199) p-S445,T599,S602,S729 BRAF [plasma membrane] (R-HSA-5672679) p-S445,S729-BRAF [cytosol] (R-HSA-5672673) p-S445,T599,S602,S729 BRAF [cytosol] (R-HSA-5672676)	0.564	2
ChEBI:47785 AMP-PNP			0.544	3
ChEBI:16761 ADP			0.544	3
UniProt:Q96A26 F162A			0.543	3
UniProt:P35579 MYH9	1	MYH9 [cytosol] (R-HSA-419173)	0.527	2
UniProt:P36896 ACVR1B	2	p-4S,T188,T206-ACVR1B [plasma membrane] (R-HSA-205780) ACVR1B [plasma membrane] (R-HSA-205867)	0.524	2
UniProt:P49840 GSK3A	3	p-S21-GSK3A [cytosol] (R-HSA-198352) p-Y279-GSK3A [cytosol] (R-HSA-9635490) GSK3A [cytosol] (R-HSA-198326)	0.524	2
UniProt:O15146 MUSK	1	MUSK [plasma membrane] (R-HSA-197753)	0.524	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-2682326)	0.524	2
UniProt:P51817 PRKX	1	PRKX [nucleoplasm] (R-HSA-3222308)	0.524	2
UniProt:O75469 NR1I2			0.524	2
UniProt:Q06187 BTK	6	p-Y551-BTK [cytosol] (R-HSA-2685603) Active BTK [cytosol] (R-HSA-8964323) p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807) BTK [cytosol] (R-HSA-197948)	0.524	2
UniProt:Q15208 STK38			0.524	2
UniProt:O94921 CDK14			0.524	2
UniProt:P53671 LIMK2	2	LIMK2 [cytosol] (R-HSA-419171) p-T505-LIMK2 [cytosol] (R-HSA-419711)	0.524	2
UniProt:Q9P215 POGK			0.524	2
UniProt:Q15139 PRKD1	1	PRKD1 [cytosol] (R-HSA-58210)	0.524	2
UniProt:P11801 KPSH1			0.524	2
UniProt:Q96Q40 CDK15			0.524	2
UniProt:P49674 CSNK1E	2	CSNK1E [nucleoplasm] (R-HSA-421306) CSNK1E [cytosol] (R-HSA-205877)	0.524	2
UniProt:Q15303 ERBB4			0.524	2
UniProt:P22607 FGFR3	40	FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 795fs139 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419) p-6Y-FGFR3 S371C [plasma membrane] (R-HSA-2011886) p-6Y-FGFR3 G370C [plasma membrane] (R-HSA-2011883) p-6Y-FGFR3 Y373C [plasma membrane] (R-HSA-2011889) p-6Y-FGFR3 795fs139 [plasma membrane] (R-HSA-2038360) p-6Y-FGFR3 R248C [plasma membrane] (R-HSA-2011884) pY-FGFR3 [plasma membrane] (R-HSA-2038368) p-6Y-FGFR3 K650Q [plasma membrane] (R-HSA-2032962) p-6Y-FGFR3 K650N [plasma membrane] (R-HSA-2032961) p-6Y-FGFR3 K650E [plasma membrane] (R-HSA-2032952) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-4Y FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853147) p-4Y FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853155) p-4Y FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853145) p-4Y FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853129) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) p-4Y FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853128) p-4Y FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853151)	0.524	2
UniProt:P06241 FYN	6	MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) p-Y420-FYN [cytosol] (R-HSA-391821) FYN [cytosol] (R-HSA-200917) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410)	0.524	2
UniProt:Q96S53 TESK2			0.524	2
UniProt:Q8TF76 HASP			0.524	2
UniProt:Q13618 CUL3	3	CUL3 [nucleoplasm] (R-HSA-5635033) CUL3 [cytosol] (R-HSA-975979) G76-NEDD8-K712-CUL3 [cytosol] (R-HSA-8952516)	0.524	2
UniProt:P06239 LCK	4	p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [plasma membrane] (R-HSA-8857940) LCK [cytosol] (R-HSA-167609) p-Y394-LCK [cytosol] (R-HSA-202308)	0.524	2
UniProt:Q9UM73 ALK			0.524	2
UniProt:Q15131 CDK10			0.524	2
UniProt:P29597 TYK2	5	p-Y-TYK2 [cytosol] (R-HSA-6784366) p-TYK2 [cytosol] (R-HSA-8950424) TYK2 [cytosol] (R-HSA-877348) p-Y1054,Y1055-TYK2 [cytosol] (R-HSA-909682) p-Y1054-TYK2 [cytosol] (R-HSA-1112598)	0.524	2
UniProt:Q16671 AMHR2	1	AMHR2 [plasma membrane] (R-HSA-8858258)	0.524	2
UniProt:P80192 M3K9			0.524	2
UniProt:P42679 MATK	1	MATK [cytosol] (R-HSA-1433581)	0.524	2
UniProt:Q9UPZ9 ICK			0.524	2
UniProt:Q13555 CAMK2G	5	p-T287-CAMK2G [endocytic vesicle membrane] (R-HSA-417014) p-T287-CAMK2G [plasma membrane] (R-HSA-432797) CAMK2G [cytosol] (R-HSA-9611358) p-T287-CAMK2G [cytosol] (R-HSA-445369) p-T287-CAMK2G [nucleoplasm] (R-HSA-444781)	0.524	2
UniProt:P31152 MAPK4	4	MAPK4 [cytosol] (R-HSA-5686973) MAPK4 [nucleoplasm] (R-HSA-5686975) p-S186 MAPK4 [cytosol] (R-HSA-5687023) p-S186 MAPK4 [nucleoplasm] (R-HSA-5687022)	0.524	2
UniProt:P35916 FLT4	1	FLT4 [plasma membrane] (R-HSA-195359)	0.524	2
UniProt:Q8TD19 NEK9	3	p-S29,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984213) p-T333-NEK9 [cytosol] (R-HSA-2530600) p-S29,T210,T333,S750,S869-NEK9 [cytosol] (R-HSA-2984225)	0.524	2
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.524	2
UniProt:Q16832 DDR2	1	DDR2 [plasma membrane] (R-HSA-211419)	0.524	2
UniProt:P49758 RGS6	1	RGS6 [plasma membrane] (R-HSA-939789)	0.524	2
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) p-T410-PRKCZ [cytosol] (R-HSA-437181) PRKCZ [cytosol] (R-HSA-58218) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824) PRKCZ [cell junction] (R-HSA-2134483)	0.524	2
UniProt:Q00534 CDK6	3	CDK6 [nucleoplasm] (R-HSA-141283) CDK6 [cytosol] (R-HSA-68336) p-T177-CDK6 [nucleoplasm] (R-HSA-69628)	0.524	2
UniProt:P31751 AKT2	8	p-T309,S474-AKT2 [cytosol] (R-HSA-166800) p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056) p-T309-AKT2 [cytosol] (R-HSA-202066) p-T309,S474-AKT2 [nucleoplasm] (R-HSA-202087) AKT2 [cytosol] (R-HSA-49859) AKT2 [plasma membrane] (R-HSA-202053) p-S474-AKT2 [plasma membrane] (R-HSA-2317312) p-T309,S474-AKT2 [cytosol] (R-HSA-202062)	0.524	2
UniProt:Q01974 ROR2	2	ROR2 [clathrin-coated endocytic vesicle membrane] (R-HSA-5140729) ROR2 [plasma membrane] (R-HSA-197731)	0.524	2
UniProt:P09769 FGR	3	FGR [secretory granule lumen] (R-HSA-6804974) FGR [extracellular region] (R-HSA-6806524) FGR [cytosol] (R-HSA-432116)	0.524	2
UniProt:Q01432 AMPD3	4	AMPD3 [extracellular region] (R-HSA-6806502) AMPD3 [secretory granule lumen] (R-HSA-6801064) AMPD3 [ficolin-1-rich granule lumen] (R-HSA-6801077) AMPD3 [cytosol] (R-HSA-49929)	0.499	2
UniProt:P62913 RPL11	1	RPL11 [cytosol] (R-HSA-72406)	0.499	2
UniProt:Q8IWX7 UN45B			0.499	2