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DSC1 [plasma membrane]
Stable Identifier
R-HSA-6801533
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Desmocollin-1, DSC1_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Keratinization (Homo sapiens)
Formation of the cornified envelope (Homo sapiens)
CASP14 cleaves filaggrin (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
CDSN binds the cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Filaggrin binds Keratin tonofilament:Desmosome (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Fillagrin and keratin intermediate filaments polymerize forming a network (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Lamellar bodies bind the early cornified envelope (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Late envelope proteins bind cornified envelope:CDSN (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Late cornified envelope [plasma membrane] (Homo sapiens)
Cornified envelope:CDSN [plasma membrane] (Homo sapiens)
Cornified envelope [plasma membrane] (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
PERP binds desmosomes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Desmosome:PERP [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Plasma membrane resorption (Homo sapiens)
Mature cornified envelope [plasma membrane] (Homo sapiens)
No FGN-cornified envelope:CDSN [plasma membrane] (Homo sapiens)
No FGN-Cornified envelope [plasma membrane] (Homo sapiens)
No FGN-late cornified envelope [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome network [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Reinforcement of the Cornified Envelope (Homo sapiens)
Early cornified envelope [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
FLG-Keratin filament network [plasma membrane] (Homo sapiens)
FLG(?-?):Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Keratin filaments bind cell-cell adhesion complexes (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Keratin tonofilament:Desmosome [plasma membrane] (Homo sapiens)
Desmosome [plasma membrane] (Homo sapiens)
Desmocolins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
DSC1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q08554 DSC1
Gene Names
DSC1, CDHF1
Chain
signal peptide:1-29, propeptide:30-134, chain:135-894
Reference Genes
BioGPS Gene:1823 DSC1
COSMIC (genes):DSC1 DSC1
CTD Gene:1823 DSC1
dbSNP Gene:1823 DSC1
ENSEMBL:ENSG00000134765 DSC1
HGNC:3035 DSC1
KEGG:hsa:1823 DSC1
Monarch:1823 DSC1
NCBI Gene:1823 DSC1
OMIM:125643 DSC1
UCSC:Q08554 DSC1
Reference Transcript
RefSeq:NM_024421.2 DSC1
RefSeq:NM_004948.3 DSC1
Other Identifiers
11740488_x_at
16854509
1823
207324_PM_s_at
207324_s_at
34619_at
3802987
3803017
3803019
3803021
3803022
3803023
3803024
3803025
3803026
3803027
3803028
3803029
3803030
3803031
3803032
3803033
3803034
3803036
3803037
3803038
3803039
3803040
3803041
8022728
A_23_P38696
GE82835
GO:0001533
GO:0005509
GO:0005515
GO:0005886
GO:0005921
GO:0007155
GO:0007156
GO:0016020
GO:0030057
GO:0043226
GO:0046872
GO:0070062
GO:0070161
GO:0098609
GO:0101003
HMNXSV003018277
ILMN_1730284
ILMN_2402640
PH_hs_0023910
TC18000437.hg
X72925_at
g13435362_3p_a_at
Participates
as a member of
Desmocolins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
DSC1 [cornified envelope]
DSC1 [ficolin-1-rich granule membrane]
Inferred To
DSC1 [plasma membrane]
(Bos taurus)
DSC1 [plasma membrane]
(Gallus gallus)
DSC1 [plasma membrane]
(Sus scrofa)
dsc2l [plasma membrane]
(Danio rerio)
Dsc1 [plasma membrane]
(Mus musculus)
Dsc1 [plasma membrane]
(Rattus norvegicus)
cdh-4 [plasma membrane]
(Caenorhabditis elegans)
dsc3 [plasma membrane]
(Xenopus tropicalis)
Cross References
ENSEMBL
ENST00000257198
,
ENST00000257197
,
ENSP00000257198
,
ENSP00000257197
OpenTargets
ENSG00000134765
HPA
ENSG00000134765-DSC1
PRO
Q08554
Pharos - Targets
Q08554
GlyGen
Q08554
HMDB Protein
HMDBP07655
PDB
5IRY
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.615
5
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