Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PPIA [extracellular exosome]
Stable Identifier
R-HSA-6801538
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular exosome
Synonyms
Cyp A protein
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-12 family signaling (Homo sapiens)
Interleukin-12 signaling (Homo sapiens)
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
Expression of Peptidyl-prolyl cis-trans isomerase A (Homo sapiens)
PPIA [extracellular exosome] (Homo sapiens)
External Reference Information
External Reference
UniProt:P62937 PPIA
Gene Names
PPIA, CYPA
Chain
initiator methionine:1, chain:1-165, chain:2-165
Reference Genes
BioGPS Gene:5478 PPIA
COSMIC (genes):PPIA PPIA
CTD Gene:5478 PPIA
dbSNP Gene:5478 PPIA
ENSEMBL:ENSG00000196262 PPIA
HGNC:9253 PPIA
KEGG Gene (Homo sapiens):5478 PPIA
Monarch:5478 PPIA
NCBI Gene:5478 PPIA
OMIM:123840 PPIA
UCSC:P62937 PPIA
Reference Transcript
RefSeq:NM_001300981.1 PPIA
RefSeq:NM_021130.4 PPIA
Other Identifiers
0002690706
11725710_a_at
11725711_x_at
11725712_s_at
11752928_x_at
11758017_x_at
11758067_x_at
201293_3p_x_at
201293_x_at
211378_3p_x_at
211378_x_at
211765_3p_x_at
211765_x_at
211978_3p_x_at
211978_x_at
212661_3p_x_at
212661_x_at
226336_at
2567594
2567597
2675551
2898671
2898673
2898675
2949035
2949036
3000074
3000075
3000080
3000081
3000083
3000085
3000087
3000091
3000092
3000093
3000094
3000095
3000096
3000097
3062970
3295264
33667_at
3374006
3569637
3602437
3915708
5478
7919436
8067978
8132642
A_23_P258340
A_24_P920125
A_24_P95038
A_32_P68459
GE79899
GO:0000187
GO:0000413
GO:0001933
GO:0001934
GO:0002376
GO:0003674
GO:0003723
GO:0003755
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005829
GO:0005925
GO:0006259
GO:0006278
GO:0006457
GO:0006464
GO:0006469
GO:0006810
GO:0006915
GO:0006950
GO:0007155
GO:0007165
GO:0008150
GO:0008219
GO:0009058
GO:0015031
GO:0016018
GO:0016020
GO:0016032
GO:0016192
GO:0016853
GO:0019058
GO:0019061
GO:0019064
GO:0019068
GO:0019076
GO:0030168
GO:0030593
GO:0030595
GO:0031410
GO:0031982
GO:0032148
GO:0032873
GO:0032991
GO:0034389
GO:0034599
GO:0034641
GO:0034774
GO:0035307
GO:0035722
GO:0040011
GO:0042118
GO:0043167
GO:0043226
GO:0043231
GO:0043312
GO:0044403
GO:0045069
GO:0045070
GO:0046790
GO:0048870
GO:0050714
GO:0050900
GO:0051082
GO:0051092
GO:0060352
GO:0061024
GO:0061944
GO:0070062
GO:0070527
GO:0075713
GO:1902176
GO:1903901
GO:1904399
GO:1904813
GO:2001233
Hs.182937.2.S1_3p_s_at
Hs.182937.3.A1_3p_at
Hs.267690.2.S1_3p_s_at
ILMN_1704529
PH_hs_0032846
X52851_rna1_at
g10863926_3p_s_at
g12654762_3p_s_at
g13543665_3p_s_at
Participant Of
output
Expression of Peptidyl-prolyl cis-trans isomerase A
Other forms of this molecule
PPIA [ficolin-1-rich granule lumen]
PPIA [secretory granule lumen]
PPIA [cytosol]
PPIA [extracellular region]
Cross References
RefSeq
NP_001287910.1
,
NP_066953.1
OpenTargets
ENSG00000196262
ZINC - Substances
PPIA_HUMAN
ZINC target
P62937
PRO
P62937
PDB
1AWU
,
1CWL
,
6GJY
,
1VBS
,
1AWV
,
5NOX
,
1CWK
,
6U5D
,
2CPL
,
6U5G
,
5NOQ
,
2ALF
,
6X4M
,
6GJI
,
6X4N
,
3K0O
,
1FGL
,
2X2A
,
1W8M
,
5T9Z
,
4YUM
,
5NOU
,
2MS4
,
1M9E
,
6BTA
,
5NOV
,
1M63
,
5KV3
,
4N1R
,
1YND
,
5KUZ
,
5FJB
,
4N1Q
,
4YUP
,
5NOW
,
1RMH
,
3RDD
,
4YUI
,
5KV7
,
1ZKF
,
3K0Q
,
1AK4
,
5KUR
,
1CWA
,
5T9W
,
5KUS
,
4YUK
,
2X2C
,
6GJJ
,
5NOS
,
1AWQ
,
6X4O
,
1M9F
,
1CWH
,
2MZU
,
5KUL
,
1AWR
,
6X4P
,
1CWF
,
6X3R
,
6GJN
,
2RMB
,
5KUN
,
5KV0
,
3CYS
,
2XGY
,
2N0T
,
2RMA
,
5KV4
,
4YUH
,
6GS6
,
3K0R
,
1OCA
,
4N1P
,
1MIK
,
1M9X
,
5WC7
,
4N1O
,
3ODI
,
1AWS
,
5NOY
,
1CWJ
,
4IPZ
,
6U5E
,
1W8V
,
4N1M
,
1AWT
,
5NOR
,
2X2D
,
1CWI
,
4CYH
,
5NOT
,
3K0M
,
6GJL
,
5KUV
,
1W8L
,
4N1S
,
4YUN
,
5KV1
,
1M9D
,
1CWO
,
2CYH
,
5T9U
,
4YUO
,
1BCK
,
5KV5
,
5LUD
,
1M9C
,
2X25
,
6I42
,
6X3Y
,
1CWM
,
6GJP
,
5F66
,
1VBT
,
5TA4
,
5KUQ
,
3CYH
,
5CYH
,
3ODL
,
1M9Y
,
4YUJ
,
4YUG
,
1NMK
,
1MF8
,
5NOZ
,
3K0P
,
4N1N
,
3K0N
,
4YUL
,
5KUU
,
6GJM
,
5KUW
,
5TA2
,
6X4Q
,
1CWB
,
5KV2
,
6U5C
,
5KUO
,
1CWC
,
6GJR
,
5KV6
Target Pathogen
5b354852be737e166372e9a3
IntEnz
5.2.1.8
HPA
ENSG00000196262-PPIA
GeneCards
P62937
Ensembl
ENST00000355968
,
ENSP00000479961
,
ENST00000489459
,
ENSP00000419425
,
ENSP00000430817
,
ENST00000620047
,
ENST00000468812
,
ENSP00000427976
,
ENSG00000196262
ZINC - Predictions - Purchasable
PPIA_HUMAN
HMDB Protein
HMDBP10691
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P59595 N
11
SUMO1-K62-ADPr-p-S177-Ncap [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
SUMO1-K62-ADPr-p-S177-Ncap [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-Ncap [cytosol]
(R-COV-9682916)
ADPr-p-S177-Ncap [cytosol]
(R-COV-9686058)
p-S177-Ncap [cytosol]
(R-COV-9683754)
Ncap [cytosol]
(R-COV-9683625)
Ncap [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-Ncap [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-Ncap [plasma membrane]
(R-COV-9686063)
N [cytosol]
(R-COV-9681657)
p-S177,S181,S185,S187,S189,S191,S195,T199,S203,S207-N [cytosol]
(R-COV-9681626)
0.676
4
UniProt:P05067 APP
20
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.666
4
UniProt:Q72497 Q72497
0.623
7
UniProt:P46108-1 CRK
0.611
4
UniProt:Q99IB8-PRO_0000045602
0.59
2
UniProt:P35613 BSG
2
BSG [Golgi membrane]
(R-HSA-204478)
BSG [plasma membrane]
(R-HSA-197673)
0.589
2
UniProt:P62841 RPS15
2
RPS15 [cytosol]
(R-HSA-72335)
RPS15 [nucleoplasm]
(R-HSA-6798706)
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q00535 CDK5
4
p-Y15-CDK5 [cytosol]
(R-HSA-399809)
CDK5 [nucleoplasm]
(R-HSA-8863586)
CDK5 [cytosol]
(R-HSA-180064)
p-Y15,S159-CDK5 [nucleoplasm]
(R-HSA-6805249)
0.556
3
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.556
3
UniProt:O43614 HCRTR2
1
HCRTR2 [plasma membrane]
(R-HSA-389421)
0.556
3
UniProt:O00429 DNM1L
2
DNM1L [cytosol]
(R-HSA-351943)
DNM1L [mitochondrial outer membrane]
(R-HSA-351942)
0.527
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:Q16849 PTPRN
0.508
3
UniProt:P0C6X7-PRO_0000037309 REP
0.508
4
UniProt:O00267 SUPT5H
1
p-SUPT5H [nucleoplasm]
(R-HSA-3009372)
0.508
2
UniProt:O95831 AIFM1
0.463
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text