Reactome | FLG2 [extracellular region]

FLG2 [extracellular region]

Stable Identifier

R-HSA-6801543

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Filaggrin-2, FILA2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q5D862 FLG2

Gene Names

FLG2, IFPS

Chain

chain:1-2391

Reference Genes

BioGPS Gene:388698 FLG2

COSMIC (genes):FLG2 FLG2

CTD Gene:388698 FLG2

dbSNP Gene:388698 FLG2

ENSEMBL:ENSG00000143520 FLG2

ENSEMBL_homo_sapiens_GENE:ENSG00000143520.6 FLG2

HGNC:33276 FLG2

KEGG Gene (Homo sapiens):388698 FLG2

Monarch:388698 FLG2

NCBI Gene:388698 FLG2

OMIM:616284 FLG2

UCSC:Q5D862 FLG2

Reference Transcript

RefSeq:NM_001014342.2 FLG2

Other Identifiers

11733396_at

1569410_PM_at

1569410_at

16693318

2435654

2435655

2435656

2435657

2435658

2435659

2435660

2435662

2435663

2435664

2435665

2435666

2435667

2435668

2435669

2435670

2435671

2435672

2435673

2435674

2435675

2435676

2435677

2435678

2435679

2435680

2435681

2435682

2435683

388698

7920175

A_33_P3297080

GE568250

GO:0001533

GO:0005198

GO:0005509

GO:0005576

GO:0005634

GO:0005737

GO:0005886

GO:0007155

GO:0031410

GO:0036457

GO:0043226

GO:0046872

GO:0046914

GO:0048730

GO:0048856

GO:0061436

GO:1904724

HMNXSV003026392

Hs2.382139.1.S1_3p_at

ILMN_1743715

PH_hs_0018654

PH_hs_0031893

TC01003246.hg

Participates

as a member of

Tertiary granule lumen proteins [extracellular region] (Homo sapiens)

Other forms of this molecule

FLG2 [tertiary granule lumen]

Inferred To

ENSRNOG00000064129 [extracellular region] (Rattus norvegicus)

FLG2 [extracellular region] (Mus musculus)

Cross References

RefSeq

NP_001014364.1

OpenTargets

ENSG00000143520

GeneCards

Q5D862

HPA

ENSG00000143520-FLG2

Ensembl

ENST00000388718, ENSP00000373370, ENSG00000143520

PRO

Q5D862

Pharos - Targets

Q5D862

Orphanet

26057

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	12

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