Reactome | CTSZ [extracellular region]

CTSZ [extracellular region]

Stable Identifier

R-HSA-6801569

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Cathepsin Z, CATZ_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9UBR2 CTSZ

Gene Names

CTSZ

Chain

signal peptide:1-23, propeptide:24-61, chain:62-303

Reference Genes

BioGPS Gene:1522 CTSZ

COSMIC (genes):CTSZ CTSZ

CTD Gene:1522 CTSZ

dbSNP Gene:1522 CTSZ

ENSEMBL:ENSG00000101160 CTSZ

HGNC:2547 CTSZ

KEGG:hsa:1522 CTSZ

Monarch:1522 CTSZ

NCBI Gene:1522 CTSZ

OMIM:603169 CTSZ

UCSC:Q9UBR2 CTSZ

Reference Transcript

RefSeq:NM_001336.3 CTSZ

Other Identifiers

11726594_at

1522

16920762

210042_PM_s_at

210042_s_at

3205250

32514_s_at

3911751

3911753

3911754

3911756

3911758

3911760

3911762

3911764

3911766

3911768

3911769

3911770

3911771

3911772

3911773

3911774

3911775

3911776

3911778

3911779

3911780

3911781

3911782

3911783

3911784

3946555

61829_at

8067279

A_23_P40240

A_33_P3250398

GE475635

GE816852

GO:0002003

GO:0003824

GO:0004180

GO:0004197

GO:0005515

GO:0005576

GO:0005615

GO:0005764

GO:0005773

GO:0005783

GO:0005788

GO:0005886

GO:0005938

GO:0006508

GO:0008234

GO:0010757

GO:0016787

GO:0030134

GO:0030312

GO:0031012

GO:0031410

GO:0033116

GO:0035580

GO:0043226

GO:0043231

GO:0051603

GO:0051604

GO:0060441

GO:0062023

GO:0070062

GO:0140096

GO:1904813

HMNXSV003014927

HMNXSV003039493

ILMN_1666269

PH_hs_0013327

TC20000992.hg

TC20001680.hg

g3650497_3p_at

p28622

p33806

Participates

as a member of

Other forms of this molecule

CTSZ [specific granule lumen]

CTSZ [ficolin-1-rich granule lumen]

(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum lumen]

(Glc)3(GlcNAc)2(Man)9-CTSZ [COPII-coated ER to Golgi transport vesicle]

(Glc)3(GlcNAc)2(Man)9-CTSZ [endoplasmic reticulum-Golgi intermediate compartment membrane]

CTSZ [plasma membrane]

CTSZ [lysosomal lumen]

CTSZ [Golgi lumen]

Inferred To

CTSZ [extracellular region] (Bos taurus)

CTSZ [extracellular region] (Canis familiaris)

CTSZ [extracellular region] (Gallus gallus)

CTSZ [extracellular region] (Sus scrofa)

Ctsz [extracellular region] (Mus musculus)

Ctsz [extracellular region] (Rattus norvegicus)

cpz-1 [extracellular region] (Caenorhabditis elegans)

ctsZ [extracellular region] (Dictyostelium discoideum)

ctsz [extracellular region] (Danio rerio)

ctsz [extracellular region] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

2354

OpenTargets

ENSG00000101160

ENSEMBL

ENSP00000217131, ENST00000217131

HPA

ENSG00000101160-CTSZ

ZINC - Substances

CATZ_HUMAN

ZINC target

Q9UBR2

PRO

Q9UBR2

Pharos - Targets

Q9UBR2

GlyGen

Q9UBR2

ZINC - Predictions - Purchasable

CATZ_HUMAN

PDB

1DEU, 1EF7

Interactors (20)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P26371 KRTAP5-9	1	KRTAP5-9 [cytosol] (R-HSA-6810265)	0.83	8
UniProt:Q9UJV3-2 MID2			0.718	6
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.666	4
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q63HR2 TENS2			0.556	3
UniProt:Q9BYR9 KRTAP2-4	1	KRTAP2-4 [cytosol] (R-HSA-6809951)	0.556	3
UniProt:Q9BYV9 BACH2			0.556	3
UniProt:Q5TD97 FHL5			0.556	3
UniProt:Q9BYR6 KRTAP3-3	1	KRTAP3-3 [cytosol] (R-HSA-6809859)	0.556	3
UniProt:Q6A162 KRT40	1	KRT40 [cytosol] (R-HSA-6809605)	0.556	3
IntAct:EBI-16436789 CCSB ORF ID			0.556	3
UniProt:Q5JR59 MTUS2			0.556	3
UniProt:O15162 PLS1			0.556	3
UniProt:Q8N9N5-2 BANP			0.556	3
UniProt:Q07627 KRTAP1-1	1	KRTAP1-1 [cytosol] (R-HSA-6809855)	0.556	3
UniProt:P60014 KRTAP10-10	1	KRTAP10-10 [cytosol] (R-HSA-6810293)	0.556	3
UniProt:Q92764 KRT35	1	KRT35 [cytosol] (R-HSA-6809595)	0.556	3
UniProt:O75031 HSF2B			0.556	3
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3

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