Reactome | Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)

Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)

Stable Identifier

R-HSA-6801766

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

extracellular region

ReviewStatus

5/5

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Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)

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Regenerating islet-derived 3 (REG3) proteins belong to the family of C-type lectins (Cash HL et al. 2006a,b; Lehotzky RE et al. 2010). REG3A and REG3G are expressed in the intestine where they moodulate the host interactions with commensal and pathogenic gut bacteria. REG3 proteins bind the peptidoglycan moieties of bacteria inducing damage to the bacterial cell wall. The antibacterial activities of REG3 proteins are restricted to Gram-positive bacteria and are tightly controlled by an inhibitory N-terminal prosegment that is removed by trypsin in vivo (Cash HL et al. 2006; Mukherjee S et al. 2009; Medveczky P et al. 2009).

Literature References

PubMed ID	Title	Journal	Year
19095652	Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment Whitham, CV, Partch, CL, Chu, H, Bevins, CL, Gardner, KH, Lehotzky, RE, Mukherjee, S, Hooper, LV	J. Biol. Chem.	2009
19254208	Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation Medveczky, P, Sahin-Tóth, M, Szmola, R	Biochem. J.	2009