Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)

Stable Identifier
R-HSA-6801766
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Regenerating islet-derived 3 (REG3) proteins belong to the family of C-type lectins (Cash HL et al. 2006a,b; Lehotzky RE et al. 2010). REG3A and REG3G are expressed in the intestine where they moodulate the host interactions with commensal and pathogenic gut bacteria. REG3 proteins bind the peptidoglycan moieties of bacteria inducing damage to the bacterial cell wall. The antibacterial activities of REG3 proteins are restricted to Gram-positive bacteria and are tightly controlled by an inhibitory N-terminal prosegment that is removed by trypsin in vivo (Cash HL et al. 2006; Mukherjee S et al. 2009; Medveczky P et al. 2009).

Literature References
PubMed ID Title Journal Year
19254208 Proteolytic activation of human pancreatitis-associated protein is required for peptidoglycan binding and bacterial aggregation

Medveczky, P, Szmola, R, Sahin-Tóth, M

Biochem. J. 2009
19095652 Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment

Mukherjee, S, Partch, CL, Lehotzky, RE, Whitham, CV, Chu, H, Bevins, CL, Gardner, KH, Hooper, LV

J. Biol. Chem. 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
serine-type peptidase activity of Trypsin 2, 3 [extracellular region]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed