Reactome: A Curated Pathway Database

REG3A binds bacterial phospholipids

Stable Identifier
R-HSA-6801776
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, cell wall
Locations in the PathwayBrowser
Summation

Structural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).

Literature References
PubMed ID Title Journal Year
24256734 Antibacterial membrane attack by a pore-forming intestinal C-type lectin Nature 2014
Participants
input
output
entityOnOtherCell
Participant Of
hasEvent
Orthologous Events
 
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