REG3A binds bacterial phospholipids

Stable Identifier
R-HSA-6801776
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, cell wall
Locations in the PathwayBrowser
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Summation

Structural studies of human REG3A by X-ray diffraction with electron microscopy suggest that REG3A binds to bacterial membrane phospholipids and kills bacteria by forming a hexameric membrane-permeabilizing pore (Mukherjee S et al. 2014).

Literature References
PubMed ID Title Journal Year
24256734 Antibacterial membrane attack by a pore-forming intestinal C-type lectin Nature 2014
Participants
Input
Output
Entity On Other Cell
Participant Of
hasEvent
Orthologous Events
REG3A binds bacterial phospholipids (Bos taurus)
REG3A binds bacterial phospholipids (Canis familiaris)
REG3A binds bacterial phospholipids (Mus musculus)
REG3A binds bacterial phospholipids (Rattus norvegicus)
REG3A binds bacterial phospholipids (Sus scrofa)
Authored
Shamovsky, Veronica, 2015-10-05
Reviewed
Hains, David S, 2016-08-02
Jupe, Steve, 2016-04-15