Reactome | ESRP1(1-606)-RAF1(227-648) fusion [cytosol]

ESRP1(1-606)-RAF1(227-648) fusion [cytosol]

Stable Identifier

R-HSA-6802312

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20526349	Rearrangements of the RAF kinase pathway in prostate cancer, gastric cancer and melanoma Shankar, S, Siddiqui, J, Kuefer, R, Chen, YB, Greenson, JK, Lafargue, CJ, Ramnarayanan, K, Han, B, Palanisamy, N, Demichelis, F, Esgueva, R, Dhanasekaran, SM, Giordano, TJ, Fullen, DR, Pflueger, D, Moeller, P, Rubin, MA, Maher, CA, Cao, Q, Cao, X, Ateeq, B, Banerjee, S, Bismar, TA, Tomlins, SA, Varambally, S, Kumar-Sinha, C, Chinnaiyan, AM, Johnson, TM, Suleman, K, Tan, P, Kalyana-Sundaram, S	Nat. Med.	2010

External Reference Information

External Reference

UniProt:Q6NXG1 ESRP1

Gene Names

ESRP1, RBM35A

Chain

chain:1-681

Reference Genes

COSMIC (genes):ESRP1 Q6NXG13

dbSNP Gene:54845 Q6NXG13

ENSEMBL:ENSG00000104413 ESRP1

Participates

as a component of

ESRP1-RAF1 fusion dimer [cytosol] (Homo sapiens)

Other forms of this molecule

ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]

ESRP1 [nucleoplasm]

Modified Residues

Name

Insertion of residues 227 to 648 at 607 from UniProt:P04049 RAF1

Coordinate

607

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
cancer	DOID:162	malignant tumor, malignant neoplasm, primary cancer
prostate cancer	DOID:10283	NGP - New growth of prostate, neoplasm of prostate (disorder), tumor of the prostate, malignant tumor of prostate (disorder), prostate neoplasm, malignant tumor of the prostate, malignant tumor of prostate (disorder), prostatic cancer, prostatic neoplasm

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.805	12
UniProt:Q6ZRY4 RBPS2			0.666	4
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) p-6Y-FGFR3 A391E [plasma membrane] (R-HSA-2065835) p-6Y-FGFR3 K650T [plasma membrane] (R-HSA-2032966) p-6Y-FGFR3 G382D [plasma membrane] (R-HSA-2032950) p-6Y-FGFR3 G380R [plasma membrane] (R-HSA-2032946) p-6Y-FGFR3 K650M [plasma membrane] (R-HSA-2032959)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P13637 ATP1A3	1	ATP1A3 [plasma membrane] (R-HSA-936803)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
IntAct:EBI-25857482 CCSB			0.556	3
UniProt:Q96G42 KLD7B			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:Q13393 PLD1	4	PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P02766 TTR	2	TTR [azurophil granule lumen] (R-HSA-6799366) TTR [extracellular region] (R-HSA-976883)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:P08670 VIM	11	Vimentin [lysosomal lumen] (R-HSA-9659977) Vimentin [cytosol] (R-HSA-9646687) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [late endosome lumen] (R-HSA-9660019) VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-429) [cytosol] (R-HSA-350317) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294) VIM(2-85) [cytosol] (R-HSA-350264)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
UniProt:P00488 F13A1	4	factor XIIIa A chain [extracellular region] (R-HSA-140788) factor XIII A chain [extracellular region] (R-HSA-140600) factor XIII A chain activation peptide [extracellular region] (R-HSA-140790) F13A1(1-731) [platelet alpha granule lumen] (R-HSA-349759)	0.556	3
UniProt:P16284 PECAM1	5	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) p-Y713-PECAM1 [plasma membrane] (R-HSA-9860772) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:P34741 SDC2	20	HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643) HS(3)-SDC2 [plasma membrane] (R-HSA-2076631) HS(5)-SDC2 [plasma membrane] (R-HSA-2076665) SDC2 [endoplasmic reticulum lumen] (R-HSA-8956741) p-SDC2 [endoplasmic reticulum lumen] (R-HSA-8956945) XylS-SDC2 [Golgi lumen] (R-HSA-2064109) Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2064132) SDC2 [Golgi lumen] (R-HSA-2054101) Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063988) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397)	0.556	3

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