BRAF G466E [cytosol]

Stable Identifier
R-HSA-6802374
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
B-RAF
BRAF G466E [cytosol] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
15035987 Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF

Wan, PT, Garnett, MJ, Roe, SM, Lee, S, Niculescu-Duvaz, D, Good, VM, Jones, CM, Marshall, CJ, Springer, CJ, Barford, D, Marais, R

Cell 2004
12068308 Mutations of the BRAF gene in human cancer

Davies, H, Bignell, GR, Cox, C, Stephens, P, Edkins, S, Clegg, S, Teague, J, Woffendin, H, Garnett, MJ, Bottomley, W, Davis, N, Dicks, E, Ewing, R, Floyd, Y, Gray, K, Hall, S, Hawes, R, Hughes, J, Kosmidou, V, Menzies, A, Mould, C, Parker, A, Stevens, C, Watt, S, Hooper, S, Wilson, R, Jayatilake, H, Gusterson, BA, Cooper, C, Shipley, J, Hargrave, D, Pritchard-Jones, K, Maitland, N, Chenevix-Trench, G, Riggins, GJ, Bigner, DD, Palmieri, G, Cossu, A, Flanagan, A, Nicholson, A, Ho, JW, Leung, SY, Yuen, ST, Weber, BL, Seigler, HF, Darrow, TL, Paterson, H, Marais, R, Marshall, CJ, Wooster, R, Stratton, MR, Futreal, PA

Nature 2002
External Reference Information
External Reference
Gene Names
BRAF, BRAF1, RAFB1
Chain
initiator methionine:1, chain:2-766
Reference Transcript
Other Identifiers
11732491_s_at
1654_at
17063631
206044_s_at
3076364
3076365
3076366
3076367
3076368
3076370
3076372
3076374
3076375
3076380
3076381
3076382
3076383
3076384
3076386
3076388
3076392
3076393
3076396
3076399
3076414
3076416
3076439
3076440
3076441
3076442
3982166
3982173
40306_at
673
8143417
86199_r_at
A_23_P42935
GE58163
GE766137
GO:0000165
GO:0000166
GO:0000186
GO:0003674
GO:0003824
GO:0004672
GO:0004674
GO:0005509
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0005975
GO:0006464
GO:0006468
GO:0006810
GO:0006950
GO:0007165
GO:0007173
GO:0008150
GO:0008152
GO:0008219
GO:0009887
GO:0010628
GO:0010828
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0033138
GO:0035556
GO:0042802
GO:0043066
GO:0043167
GO:0043226
GO:0043231
GO:0046872
GO:0048856
GO:0055085
GO:0070374
GO:0070413
GO:0071277
GO:0090150
GO:0097110
ILMN_1652472
M95712_at
PH_hs_0027912
TC07001927.hg
g4757867_3p_a_at
Participant Of
Other forms of this molecule
Modified Residues
Name
glycine 466 replaced with L-glutamic acid
Coordinate
466
PsiMod
A protein modification that effectively converts a source amino acid residue to an L-glutamic acid.
A protein modification that effectively removes or replaces an glycine.
Disease
Name Identifier Synonyms
melanoma 1909 Naevocarcinoma, melanoma, melanoma, malignant melanoma, morphology (morphologic abnormality), malignant melanoma NOS (morphologic abnormality), malignant melanoma (disorder), malignant melanoma, malignant melanoma, malignant melanoma, malignant melanoma
Cross References
RefSeq
ZINC - World Drugs
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
COSMIC
GeneCards
Orphanet
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (25)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q02750 MAP2K1  27 0.977 60
 UniProt:P04049 RAF1  54 0.959 57
 UniProt:P15056 BRAF  68 0.907 13
 UniProt:P63104 YWHAZ  2 0.899 10
 UniProt:P31946 YWHAB  1 0.818 7
 UniProt:P61981 YWHAG  1 0.813 7
 UniProt:P27348 YWHAQ  1 0.813 7
 UniProt:P10398 ARAF  4 0.802 6
 UniProt:P36507 MAP2K2  12 0.802 9
 UniProt:P01112 HRAS  23 0.783 5
 UniProt:P08238 HSP90AB1  6 0.669 4
 UniProt:Q04917 YWHAH  1 0.643 6
 UniProt:P62258 YWHAE  1 0.643 4
 UniProt:Q13233 MAP3K1  2 0.609 2
 UniProt:P01111 NRAS  25 0.591 3
 UniProt:Q02156 PRKCE  2 0.589 3
 UniProt:P31947 SFN  1 0.564 3
 UniProt:P46940 IQGAP1  3 0.544 4
 UniProt:Q16543 CDC37  1 0.527 3
 UniProt:Q8N122 RPTOR  3 0.527 2
 UniProt:P11021 HSPA5  6 0.527 3
 UniProt:P38646 HSPA9  6 0.527 2
 UniProt:P11142 HSPA8  10 0.527 2
 UniProt:Q61097  5 0.499 3
 UniProt:Q99N57  10 0.499 3
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