LMNA(1-567)-RAF1(279-648) fusion [cytosol]

Stable Identifier
R-HSA-6802399
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
25204415 The landscape of kinase fusions in cancer

Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E

Nat Commun 2014
External Reference Information
External Reference
Gene Names
LMNA, LMN1
Chain
chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664
Participates
Other forms of this molecule
Modified Residues
Name
Insertion of residues 279 to 648 at 568 from UniProt:P04049 RAF1
Coordinate
568
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
skin melanoma DOID:8923 malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
Interactors (90)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P20700 LMNB1  8 0.933 23
 UniProt:Q03252 LMNB2      0.849 10
 UniProt:P50402 EMD  4 0.799 7
 UniProt:Q9UII6 DS13B      0.781 7
 UniProt:P13569 CFTR  17 0.774 23
 UniProt:Q9UH99 SUN2  1 0.723 5
 UniProt:O75694 NUP155  2 0.672 6
 UniProt:Q13573 SNW1  1 0.666 4
 UniProt:P42166 TMPO      0.629 4
 UniProt:P16104 H2AFX  7 0.604 3
 UniProt:Q0D2I5-5 IFFO1      0.576 4
 UniProt:O60684 KPNA6  2 0.569 5
 UniProt:P42167 TMPO  1 0.569 4
 UniProt:O94901 SUN1  1 0.564 2
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:P62701 RPS4X  2 0.556 3
 UniProt:Q3B820 F161A      0.556 3
 UniProt:Q7Z699 SPRED1  2 0.556 3
 UniProt:Q96MN9-2 Q96MN92      0.556 3
 UniProt:Q7Z698 SPRED2  2 0.556 3
 UniProt:Q96LX8 ZNF597  1 0.556 3
 UniProt:Q8WXF7 ATLA1      0.556 3
 UniProt:Q86WT6-2 TRIM69      0.556 3
 UniProt:Q70EL1-9 USP54      0.556 3
 UniProt:Q9C0F3 ZNF436  1 0.556 3
 UniProt:P17024 ZNF20  1 0.556 3
 UniProt:Q9NWB1-5 RBFOX1      0.556 3
 UniProt:Q14585 ZN345      0.556 3
 UniProt:Q6ZNH5 ZN497      0.556 3
 IntAct:EBI-25842396 CCSB      0.556 3
 UniProt:P60409 KRTAP10-7  1 0.556 3
 UniProt:Q04323-2 UBXN1      0.556 3
 IntAct:EBI-10171679 386682      0.556 3
 UniProt:Q9BS31 ZNF649  1 0.556 3
 UniProt:O43309 ZSC12      0.556 3
 UniProt:Q7Z3I7 ZN572      0.556 3
 UniProt:Q8IZU1 FAM9A      0.556 3
 UniProt:Q9Y4E8-2 USP15      0.556 3
 UniProt:Q96EL1 INKA1      0.556 3
 UniProt:P46379-2 BAG6      0.556 3
 UniProt:Q9HBE1-4 PATZ1      0.556 3
 UniProt:Q6H8Q1-8 ABLIM2      0.556 3
 UniProt:Q9BZ95-3 Q9BZ953      0.556 3
 UniProt:Q8N0Y2-2 ZNF444      0.556 3
 UniProt:A6H8Z2-3 A6H8Z23      0.556 3
 UniProt:O76041 NEBL      0.556 3
 UniProt:Q99612 KLF6      0.556 3
 UniProt:Q96GN5-2 CDCA7L      0.556 3
 UniProt:Q96KP6 TNIP3  1 0.556 3
 UniProt:Q8TBE0 BAHD1      0.556 3
 UniProt:Q8NEA9 GMCL2      0.556 3
 UniProt:Q12986 NFX1      0.556 3
 UniProt:Q5VYS8-5 TUT7      0.556 3
 UniProt:Q03181-2 PPARD      0.556 3
 UniProt:Q8NA54 IQUB      0.556 3
 UniProt:Q8WVD3 RNF138  1 0.556 3
 UniProt:Q8TCX5 RHPN1  1 0.556 3
 UniProt:Q8TBZ8 ZNF564  1 0.556 3
 UniProt:Q14005-2 Q140052      0.556 3
 UniProt:Q15776 ZKSCAN8  1 0.556 3
 UniProt:Q96FA3 PELI1  2 0.556 3
 UniProt:Q9UNE7 STUB1  1 0.556 3
 UniProt:Q8WW38 ZFPM2  1 0.556 3
 UniProt:O75925 PIAS1  1 0.556 3
 UniProt:Q9ULD4-2 Q9ULD42      0.556 3
 UniProt:Q96DX5 ASB9  1 0.556 3
 UniProt:Q8N488 RYBP  1 0.556 3
 UniProt:Q8IYM2 SLN12      0.556 3
 UniProt:Q13123 IK  1 0.556 3
 UniProt:Q9Y239 NOD1  1 0.556 3
 IntAct:EBI-25851697 CCSB      0.556 3
 UniProt:Q3SX64 CMA1D      0.556 3
 UniProt:Q6ZN57 ZFP2  1 0.556 3
 UniProt:Q6X4W1-6 NSMF      0.556 3
 UniProt:O75886 STAM2  2 0.556 3
 UniProt:Q13133-3 NR1H3      0.556 3
 UniProt:P10074 TZAP      0.556 3
 UniProt:P58499 FAM3B      0.556 3
 UniProt:P54274-2 TERF1      0.556 3
 UniProt:P10073 ZSC22      0.556 3
 UniProt:Q6ZNE9 RUFY4      0.556 3
 UniProt:Q9D666 Sun1  1 0.528 2
 UniProt:O75531 BANF1  4 0.527 2
 UniProt:P17029 ZKSCAN1  1 0.527 2
 UniProt:P01106 MYC  2 0.527 3
 UniProt:P18054 ALOX12  1 0.508 4
 UniProt:Q8NC56 LEMD2  1 0.491 2
 UniProt:O75937 DNAJC8  1 0.483 3
 UniProt:Q9H2H8 PPIL3  1 0.483 2
 UniProt:Q8WXH0-1 SYNE2      0.463 3
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