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PAPD7(1-653)-RAF1(331-648) fusion [cytosol]
Stable Identifier
R-HSA-6802430
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Oncogenic MAPK signaling (Homo sapiens)
Signaling by BRAF and RAF1 fusions (Homo sapiens)
BRAF and RAF fusion mutant dimers are phosphorylated (Homo sapiens)
BRAF/RAF fusion dimers [cytosol] (Homo sapiens)
PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
PAPD7(1-653)-RAF1(331-648) fusion [cytosol] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
25204415
The landscape of kinase fusions in cancer
Kim, JL
,
Schalm, S
,
Stransky, N
,
Lengauer, C
,
Cerami, E
Nat Commun
2014
External Reference Information
External Reference
UniProt:Q5XG87 TENT4A
Gene Names
TENT4A, PAPD7, POLS, TRF4
Chain
chain:1-772
Reference Genes
BioGPS Gene:11044 TENT4A
COSMIC (genes):TENT4A TENT4A
CTD Gene:11044 TENT4A
dbSNP Gene:11044 TENT4A
ENSEMBL:ENSG00000112941 PAPD7
HGNC:16705 TENT4A
KEGG Gene (Homo sapiens):11044 TENT4A
Monarch:11044 TENT4A
NCBI Gene:11044 TENT4A
OMIM:605198 TENT4A
UCSC:Q5XG87 TENT4A
Reference Transcript
RefSeq:NM_006999.4 TENT4A
RefSeq:NM_001171805.1 TENT4A
RefSeq:NM_001171806.1 TENT4A
Other Identifiers
11044
16982959
2800515
2800532
2800533
2800534
2800535
2800537
2800538
2800539
2800542
2800544
2800547
2800550
2800553
2800554
2800556
2800557
8104378
GO:0000166
GO:0000278
GO:0003674
GO:0004652
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005654
GO:0005730
GO:0005737
GO:0005794
GO:0006259
GO:0006302
GO:0006397
GO:0006412
GO:0006950
GO:0007049
GO:0007059
GO:0007062
GO:0007076
GO:0008150
GO:0009056
GO:0009058
GO:0009410
GO:0016740
GO:0016779
GO:0031123
GO:0031499
GO:0031965
GO:0032991
GO:0034641
GO:0034655
GO:0043167
GO:0043221
GO:0043226
GO:0043631
GO:0046872
GO:0051276
GO:0060212
GO:0070568
GO:0071076
GO:0140014
GO:1905870
HMNXSV003006156
TC05000045.hg
Participates
as a component of
PAPD7-RAF1 fusion dimer [cytosol] (Homo sapiens)
Other forms of this molecule
PAPD7(1-653)-p-RAF1(331-648) fusion [cytosol]
Modified Residues
Name
Insertion of residues 331 to 648 at 654 from UniProt:P04049 RAF1
Coordinate
654
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name
Identifier
Synonyms
prostate adenocarcinoma
DOID:2526
adenocarcinoma of prostate (disorder), prostate adenocarcinoma
cancer
DOID:162
malignant tumor, malignant neoplasm, primary cancer
Cross References
RefSeq
NP_008930.1
,
NP_001165277.1
,
NP_001165276.1
OpenTargets
ENSG00000112941
IntEnz
2.7.7.19
GeneCards
Q5XG87
HPA
ENSG00000112941-TENT4A
Ensembl
ENST00000631941
,
ENSG00000112941
,
ENSP00000488642
PRO
Q5XG87
Pharos - Targets
Q5XG87
HMDB Protein
HMDBP11873
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