FAM131B(1-18)-p-BRAF(381-766) fusion [cytosol]

Stable Identifier
R-HSA-6802527
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
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Literature References
PubMed ID Title Journal Year
21424530 Oncogenic FAM131B-BRAF fusion resulting from 7q34 deletion comprises an alternative mechanism of MAPK pathway activation in pilocytic astrocytoma

Herr, R, Scheurlen, W, Jabado, N, Jacob, K, Gnekow, A, Collins, VP, Lichter, P, Pekrun, A, Falkenstein, F, Meyer, C, Remke, M, von Deimling, A, Witt, H, Korshunov, A, Pfister, SM, Marschalek, R, Cin, H, Bender, S, Benner, A, Omran, H, Olbrich, H, Van Anh, TN, Kulozik, AE, Witt, O, Lambert, S, Janzarik, WG, Brummer, T, Jones, DT

Acta Neuropathol. 2011
External Reference Information
External Reference
UniProt:Q86XD5 FAM131B
Gene Names
FAM131B, KIAA0773
Chain
initiator methionine:, chain:1-332
Reference Genes
BioGPS Gene:9715 FAM131B
COSMIC (genes):FAM131B FAM131B
CTD Gene:9715 FAM131B
dbSNP Gene:9715 FAM131B
ENSEMBL:ENSG00000159784 FAM131B
ENSEMBL_homo_sapiens_GENE:ENSG00000159784.18 FAM131B
HGNC:22202 FAM131B
KEGG Gene (Homo sapiens):9715 FAM131B
Monarch:9715 FAM131B
NCBI Gene:9715 FAM131B
OMIM:619282 FAM131B
UCSC:Q86XD5 FAM131B
Reference Transcript
Other Identifiers
11726950_a_at
11726951_s_at
11726952_a_at
17063930
205368_PM_at
205368_at
3077272
3077274
3077275
3077276
3077277
3077278
3077279
3077280
3077281
3077282
3077283
3077284
3077285
3077286
3077287
3077288
3077290
3077294
3077296
3077297
3077298
3077299
3077300
3077301
3077302
3077303
3077304
41873_at
8143564
9715
A_23_P215718
A_24_P252310
A_33_P3270668
GE53480
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0043226
HMNXSV003043219
ILMN_1652694
ILMN_1736127
ILMN_1752280
PH_hs_0008174
TC07001969.hg
g7662299_3p_at
g7662299_3p_x_at
Participates
as a component of
Other forms of this molecule
FAM131B(1-18)-BRAF(381-766) fusion [cytosol]
Modified Residues
Name
Insertion of residues 381 to 766 at 19 from UniProt:P15056 BRAF
Coordinate
19
Name
O-phospho-L-serine at 446
Coordinate
446
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 729
Coordinate
729
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 599
Coordinate
599
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 602
Coordinate
602
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
pilocytic astrocytoma DOID:4851 Piloid astrocytoma, grade I Astrocytic tumor
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
Interactors (5)
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