Reactome | p-LMNA-RAF1 fusion [cytosol]

p-LMNA-RAF1 fusion [cytosol]

Stable Identifier

R-HSA-6802537

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Stransky, N, Cerami, E, Schalm, S, Kim, JL, Lengauer, C	Nat Commun	2014

External Reference Information

External Reference

UniProt:P02545 LMNA

Gene Names

LMNA, LMN1

Chain

chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664

Reference Genes

BioGPS Gene:4000 LMNA

COSMIC (genes):LMNA LMNA

CTD Gene:4000 LMNA

dbSNP Gene:4000 LMNA

ENSEMBL:ENSG00000160789 LMNA

HGNC:6636 LMNA

KEGG Gene (Homo sapiens):4000 LMNA

Monarch:4000 LMNA

NCBI Gene:4000 LMNA

OMIM:150330 LMNA

UCSC:P02545 LMNA

Reference Transcript

Other Identifiers

0001740242

0002970021

11719260_x_at

11719261_s_at

11752340_x_at

11752506_s_at

11752507_x_at

11752673_x_at

1554600_s_at

16671914

203411_s_at

212086_x_at

212089_at

2361280

2361282

2361283

2361298

2361299

2361300

2361301

2361302

2361303

2361308

2361309

2361312

2361313

2361314

2361316

2361317

2361320

2361322

2361323

2361325

2361327

2361329

2361330

2361331

2361334

2361335

2361337

2361338

37377_i_at

37378_r_at

4000

71746_s_at

7906085

A_14_P114205

A_23_P34835

A_24_P162718

A_33_P3311285

A_33_P3408762

GE81529

GO:0000278

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005635

GO:0005638

GO:0005652

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0006464

GO:0006606

GO:0006810

GO:0006913

GO:0006950

GO:0006997

GO:0006998

GO:0007005

GO:0007010

GO:0007049

GO:0007084

GO:0007165

GO:0007568

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0010628

GO:0015031

GO:0016604

GO:0016607

GO:0030154

GO:0030334

GO:0030951

GO:0031647

GO:0031965

GO:0034504

GO:0036498

GO:0040011

GO:0043226

GO:0048856

GO:0048870

GO:0051276

GO:0055015

GO:0061024

GO:0071456

GO:0072201

GO:0090201

GO:0090343

GO:1900114

GO:1900180

GO:1903243

GO:2001237

Hs.77886.1.S1_3p_a_at

Hs.77886.2.S2_3p_at

Hs2.377973.4.S1_3p_s_at

ILMN_1696749

ILMN_1737394

M13452_s_at

PH_hs_0025504

g5031874_3p_a_at

Participant Of

hasComponent

p-LMNA-RAF1 fusion dimer [cytosol]

Other forms of this molecule

LMNA(1-664) [nucleoplasm]

LMNA-RAF1 fusion [cytosol]

Modified Residues

Name

Insertion of residues 279 to 648 at 568 from UniProt:P04049 RAF1

Coordinate

568

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 338

Coordinate

338

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 341

Coordinate

341

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 491

Coordinate

491

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 494

Coordinate

494

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
skin melanoma	8923	malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
cancer	162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_733821.1, NP_001269554.1, NP_001244303.1, NP_001269555.1, NP_733822.1, NP_005563.1, NP_001269553.1

OpenTargets

ENSG00000160789

HPA

ENSG00000160789-LMNA

GeneCards

P02545

Ensembl

ENST00000368299, ENST00000347559, ENST00000368300, ENST00000368301, ENST00000448611, ENSP00000292304, ENSP00000357282, ENSP00000421821, ENSP00000357284, ENSP00000357283, ENST00000473598, ENSG00000160789, ENSP00000395597

PRO

P02545

Orphanet

16364

PDB

3V4W, 1IFR, 6SNZ, 1X8Y, 2XV5, 1IVT, 2YPT, 6JLB, 3V4Q, 3V5B, 3GEF, 6GHD

Interactors (28)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.813	9
UniProt:Q9UII6 DS13B			0.781	7
UniProt:P42166 TMPO			0.642	4
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.642	4
UniProt:P16104 H2AX	7	p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.641	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.641	4
UniProt:Q03252 LMNB2			0.623	5
UniProt:P42167 TMPO			0.597	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:Q8TBZ8 ZNF564	1	ZNF564 [nucleoplasm] (R-HSA-1973885)	0.556	3
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
UniProt:Q96FA3 PELI1	2	p-PELI1 [cytosol] (R-HSA-450815) PELI1 [cytosol] (R-HSA-450696)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.528	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.527	11
UniProt:P18054 ALOX12	1	ALOX12 [cytosol] (R-HSA-2142768)	0.508	4
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.491	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.491	2
UniProt:Q8WXH0-1 SYNE2			0.463	3
UniProt:Q9Y2U8 LEMD3	1	LEMD3 [nuclear envelope] (R-HSA-2993886)	0.462	4
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.462	3
UniProt:P15927 RPA2	2	p-S33-RPA2 [nucleoplasm] (R-HSA-5685148) RPA2 [nucleoplasm] (R-HSA-68457)	0.462	3
UniProt:O60684 IMA7			0.462	4
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.462	3
UniProt:Q14739 LBR	2	LBR [nuclear envelope] (R-HSA-194637) p-S71,S86-LBR [nuclear envelope] (R-HSA-9624811)	0.462	4
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) SUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.462	2
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.462	3