Reactome | p-LMNA-RAF1 fusion [cytosol]

p-LMNA-RAF1 fusion [cytosol]

Stable Identifier

R-HSA-6802537

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
25204415	The landscape of kinase fusions in cancer Stransky, N, Cerami, E, Schalm, S, Kim, JL, Lengauer, C	Nat Commun	2014

External Reference Information

External Reference

UniProt:P02545 LMNA

Gene Names

LMNA, LMN1

Chain

chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664

Reference Genes

BioGPS Gene:4000 LMNA

COSMIC (genes):LMNA LMNA

CTD Gene:4000 LMNA

dbSNP Gene:4000 LMNA

ENSEMBL:ENSG00000160789 LMNA

HGNC:6636 LMNA

KEGG Gene (Homo sapiens):4000 LMNA

Monarch:4000 LMNA

NCBI Gene:4000 LMNA

OMIM:150330 LMNA

UCSC:P02545 LMNA

Reference Transcript

Other Identifiers

0001740242

0002970021

11719260_x_at

11719261_s_at

11752340_x_at

11752506_s_at

11752507_x_at

11752673_x_at

1554600_s_at

16671914

1IFR

1IVT

1X8Y

203411_s_at

212086_x_at

212089_at

2361280

2361282

2361283

2361298

2361299

2361300

2361301

2361302

2361303

2361308

2361309

2361312

2361313

2361314

2361316

2361317

2361320

2361322

2361323

2361325

2361327

2361329

2361330

2361331

2361334

2361335

2361337

2361338

2XV5

2YPT

37377_i_at

37378_r_at

3GEF

3V4Q

3V4W

3V5B

4000

4022

6660

6GHD

71746_s_at

7906085

A0A0C4DGC5

A0A384MQX1

A_14_P114205

A_23_P34835

A_24_P162718

A_33_P3311285

A_33_P3408762

AAA36160

AAA36164

AAH00511

AAH03162

AAH14507

AAK59326

AAR29466

AAW32538

AAW32540

ADO22171

AF381029

AK295390

AL135927

AL355388

AL356734

AY357727

AY847595

AY847597

BAG58344

BC000511

BC003162

BC014507

CAA27173

CAA27174

CAB004022

CCDS1129

CCDS1131

CCDS58038

CCDS72941

CH471121

D6RB20

EAW52997

EAW52999

ENSG00000160789

ENSP00000292304

ENSP00000357280

ENSP00000357282

ENSP00000357283

ENSP00000357284

ENSP00000395597

ENSP00000421821

ENST00000347559

ENST00000347559.6

ENST00000368297

ENST00000368299

ENST00000368299.7

ENST00000368300

ENST00000368300.8

ENST00000368301

ENST00000368301.6

ENST00000448611

ENST00000448611.6

ENST00000473598

ENST00000473598.6

EntrezGene:4000

EntrezGene:LMNA

g5031874_3p_a_at

GE81529

GO:0000278

GO:0003674

GO:0005198

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005635

GO:0005638

GO:0005652

GO:0005654

GO:0005737

GO:0005829

GO:0005856

GO:0005882

GO:0006464

GO:0006606

GO:0006810

GO:0006913

GO:0006950

GO:0006997

GO:0006998

GO:0007005

GO:0007010

GO:0007049

GO:0007084

GO:0007165

GO:0007568

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0010628

GO:0016607

GO:0030154

GO:0030334

GO:0030951

GO:0031647

GO:0031965

GO:0034504

GO:0036498

GO:0040011

GO:0043226

GO:0048856

GO:0048870

GO:0051276

GO:0055015

GO:0061024

GO:0071456

GO:0072201

GO:0090201

GO:0090343

GO:1900114

GO:1900180

GO:1903243

GO:2001237

GQ891309

H0YAB0

HGNC:6636

HPA006660

Hs.77886.1.S1_3p_a_at

Hs.77886.2.S2_3p_at

Hs2.377973.4.S1_3p_s_at

ILMN_1696749

ILMN_1737394

IPR001322

IPR018039

IPR036415

IPR039008

LMNA

LMNA-201

LMNA-205

LMNA-206

LMNA-207

LMNA-208

LMNA-213

LRG_254

LRG_254t1

M13451

M13452

M13452_s_at

MIM:115200

MIM:150330

MIM:151660

MIM:176670

MIM:181350

MIM:212112

MIM:248370

MIM:275210

MIM:605588

MIM:610140

MIM:613205

MIM:616516

NM_001257374

NM_001282625

NM_001282626

NM_005572

NM_170707

NM_170708

NP_001244303

NP_001269554

NP_001269555

NP_005563

NP_733821

NP_733822

PF00038

PF00932

PH_hs_0025504

Q3BDU5

Q5TCI8

SM01391

UPI000002AD0F

UPI000002AD10

UPI000012E20D

UPI00002318D2

UPI0000D46791

UPI0001AE794A

X03444

X03445

XM_011509533

XM_011509534

XP_011507835

XP_011507836

XR_921781

Participant Of

hasComponent

p-LMNA-RAF1 fusion dimer [cytosol]

Other forms of this molecule

LMNA-RAF1 fusion [cytosol]

LMNA(1-664) [nucleoplasm]

Modified Residues

Name

Insertion of residues 279 to 648 at 568 from UniProt:P04049 RAF1

Coordinate

568

Name

O-phospho-L-serine at 621

Coordinate

621

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 338

Coordinate

338

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O4'-phospho-L-tyrosine at 341

Coordinate

341

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O-phospho-L-threonine at 491

Coordinate

491

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

O-phospho-L-serine at 494

Coordinate

494

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Disease

Name	Identifier	Synonyms
skin melanoma	8923	malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
cancer	162	malignant tumor, malignant neoplasm, primary cancer

Cross References

RefSeq

NP_005563.1, NP_001269553.1, NP_001244303.1, NP_001269555.1, NP_001269554.1, NP_733821.1, NP_733822.1

OpenTargets

ENSG00000160789

GeneCards

P02545

PRO

P02545

Orphanet

16364

PDB

3V4Q, 3V4W, 3GEF, 6GHD, 3V5B, 2XV5, 1IFR, 1X8Y, 1IVT, 2YPT

Interactors (25)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.813	9
UniProt:P42166 TMPO			0.642	4
UniProt:P16104 H2AFX	7	p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) H2AFX [nucleoplasm] (R-HSA-56151) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317) H2AFX [extracellular region] (R-HSA-977583)	0.641	3
UniProt:Q9UH99 SUN2	1	SUN2 [nuclear envelope] (R-HSA-912382)	0.641	4
UniProt:Q03252 LMNB2			0.623	5
UniProt:P42167 TMPO			0.597	4
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P60409 KRTAP10-7	1	KRTAP10-7 [cytosol] (R-HSA-6810279)	0.556	3
IntAct:EBI-10171679 386682			0.556	3
UniProt:Q9UII6 DS13B			0.556	3
UniProt:Q9D666 Sun1	1	Sun1 [nuclear envelope] (R-MMU-912375)	0.528	2
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	3
UniProt:P18054 ALOX12	1	ALOX12 [cytosol] (R-HSA-2142768)	0.508	4
UniProt:P49790 NUP153	1	NUP153 [nucleoplasm] (R-HSA-157695)	0.491	4
UniProt:Q8NC56 LEMD2	1	LEMD2 [nuclear envelope] (R-HSA-3067329)	0.491	2
UniProt:Q96FA3 PELI1	2	p-PELI1 [cytosol] (R-HSA-450815) PELI1 [cytosol] (R-HSA-450696)	0.488	2
UniProt:Q9Y2U8 LEMD3	1	LEMD3 [nuclear envelope] (R-HSA-2993886)	0.462	4
UniProt:Q9UKX7 NUP50	1	NUP50 [nucleoplasm] (R-HSA-157740)	0.462	3
UniProt:P52294 KPNA1	2	KPNA1 [nucleoplasm] (R-HSA-188865) KPNA1 [cytosol] (R-HSA-180612)	0.462	3
UniProt:P27694 RPA1	2	RPA1 [nucleoplasm] (R-HSA-68461) SUMO2,3-K449,K577-RPA1 [nucleoplasm] (R-HSA-4551644)	0.462	2
UniProt:P15927 RPA2	2	RPA2 [nucleoplasm] (R-HSA-68457) p-S33-RPA2 [nucleoplasm] (R-HSA-5685148)	0.462	3
UniProt:P50402 EMD	3	EMD [cytosol] (R-HSA-9613988) EMD [endoplasmic reticulum membrane] (R-HSA-9613998) EMD [nuclear envelope] (R-HSA-201573)	0.462	3
UniProt:Q14739 LBR	1	LBR [nuclear envelope] (R-HSA-194637)	0.462	4
UniProt:Q93009 USP7	2	USP7 [nucleoplasm] (R-HSA-3215278) USP7 [cytosol] (R-HSA-8853511)	0.462	3
UniProt:O60684 IMA7			0.462	4