p-LMNA-RAF1 fusion [cytosol]

Stable Identifier
R-HSA-6802537
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
25204415 The landscape of kinase fusions in cancer

Stransky, N, Cerami, E, Schalm, S, Kim, JL, Lengauer, C

Nat Commun 2014
External Reference Information
External Reference
Gene Names
LMNA, LMN1
Chain
chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664
Other Identifiers
0001740242
0002970021
11719260_x_at
11719261_s_at
11752340_x_at
11752506_s_at
11752507_x_at
11752673_x_at
1554600_s_at
16671914
203411_s_at
212086_x_at
212089_at
2361280
2361282
2361283
2361298
2361299
2361300
2361301
2361302
2361303
2361308
2361309
2361312
2361313
2361314
2361316
2361317
2361320
2361322
2361323
2361325
2361327
2361329
2361330
2361331
2361334
2361335
2361337
2361338
37377_i_at
37378_r_at
4000
71746_s_at
7906085
A_14_P114205
A_23_P34835
A_24_P162718
A_33_P3311285
A_33_P3408762
GE81529
GO:0000278
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005638
GO:0005652
GO:0005654
GO:0005737
GO:0005829
GO:0005856
GO:0005882
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006950
GO:0006997
GO:0006998
GO:0007005
GO:0007010
GO:0007049
GO:0007084
GO:0007165
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0010628
GO:0015031
GO:0016604
GO:0016607
GO:0030154
GO:0030334
GO:0030951
GO:0031647
GO:0031965
GO:0034504
GO:0036498
GO:0040011
GO:0043226
GO:0048856
GO:0048870
GO:0051276
GO:0055015
GO:0061024
GO:0071456
GO:0072201
GO:0090201
GO:0090343
GO:1900114
GO:1900180
GO:1903243
GO:2001237
Hs.77886.1.S1_3p_a_at
Hs.77886.2.S2_3p_at
Hs2.377973.4.S1_3p_s_at
ILMN_1696749
ILMN_1737394
M13452_s_at
PH_hs_0025504
g5031874_3p_a_at
Participant Of
Other forms of this molecule
Modified Residues
Name
Insertion of residues 279 to 648 at 568 from UniProt:P04049 RAF1
Coordinate
568
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 338
Coordinate
338
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341
Coordinate
341
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-threonine at 491
Coordinate
491
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494
Coordinate
494
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
skin melanoma 8923 malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
cancer 162 malignant tumor, malignant neoplasm, primary cancer
Interactors (28)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P20700 LMNB1  8 0.813 9
 UniProt:Q9UII6 DS13B      0.781 7
 UniProt:P42166 TMPO      0.642 4
 UniProt:P50402 EMD  3 0.642 4
 UniProt:P16104 H2AX  7 0.641 3
 UniProt:Q9UH99 SUN2  1 0.641 4
 UniProt:Q03252 LMNB2      0.623 5
 UniProt:P42167 TMPO      0.597 4
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:Q8TBZ8 ZNF564  1 0.556 3
 UniProt:P60409 KRTAP10-7  1 0.556 3
 UniProt:Q96FA3 PELI1  2 0.556 3
 IntAct:EBI-10171679 386682      0.556 3
 UniProt:Q9D666 Sun1  1 0.528 2
 UniProt:P01106 MYC  2 0.527 3
 UniProt:P13569 CFTR  17 0.527 11
 UniProt:P18054 ALOX12  1 0.508 4
 UniProt:P49790 NUP153  1 0.491 4
 UniProt:Q8NC56 LEMD2  1 0.491 2
 UniProt:Q8WXH0-1 SYNE2      0.463 3
 UniProt:Q9Y2U8 LEMD3  1 0.462 4
 UniProt:Q9UKX7 NUP50  1 0.462 3
 UniProt:P15927 RPA2  2 0.462 3
 UniProt:O60684 IMA7      0.462 4
 UniProt:P52294 KPNA1  2 0.462 3
 UniProt:Q14739 LBR  2 0.462 4
 UniProt:P27694 RPA1  2 0.462 2
 UniProt:Q93009 USP7  2 0.462 3
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