p-LMNA-RAF1 fusion [cytosol]

Stable Identifier
R-HSA-6802537
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Literature References
PubMed ID Title Journal Year
25204415 The landscape of kinase fusions in cancer

Kim, JL, Schalm, S, Stransky, N, Lengauer, C, Cerami, E

Nat Commun 2014
External Reference Information
External Reference
UniProt:P02545 LMNA
Gene Names
LMNA, LMN1
Chain
chain:1-661, chain:1-646, propeptide:647-661, propeptide:662-664
Reference Genes
BioGPS Gene:4000 LMNA
COSMIC (genes):LMNA LMNA
CTD Gene:4000 LMNA
dbSNP Gene:4000 LMNA
ENSEMBL:ENSG00000160789 LMNA
HGNC:6636 LMNA
KEGG Gene (Homo sapiens):4000 LMNA
Monarch:4000 LMNA
NCBI Gene:4000 LMNA
OMIM:150330 LMNA
UCSC:P02545 LMNA
Reference Transcript
Other Identifiers
0001740242
0002970021
11719260_x_at
11719261_s_at
11752340_x_at
11752506_s_at
11752507_x_at
11752673_x_at
1554600_s_at
16671914
203411_s_at
212086_x_at
212089_at
2361280
2361282
2361283
2361298
2361299
2361300
2361301
2361302
2361303
2361308
2361309
2361312
2361313
2361314
2361316
2361317
2361320
2361322
2361323
2361325
2361327
2361329
2361330
2361331
2361334
2361335
2361337
2361338
37377_i_at
37378_r_at
4000
71746_s_at
7906085
A_14_P114205
A_23_P34835
A_24_P162718
A_33_P3311285
A_33_P3408762
GE81529
GO:0000278
GO:0003674
GO:0005198
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005635
GO:0005638
GO:0005652
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005856
GO:0005882
GO:0006259
GO:0006464
GO:0006606
GO:0006810
GO:0006913
GO:0006950
GO:0006997
GO:0006998
GO:0007005
GO:0007010
GO:0007049
GO:0007084
GO:0007165
GO:0007517
GO:0007568
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0010628
GO:0015031
GO:0016363
GO:0016604
GO:0016607
GO:0030154
GO:0030334
GO:0030951
GO:0031647
GO:0031965
GO:0032204
GO:0034504
GO:0034613
GO:0034641
GO:0035861
GO:0036498
GO:0040011
GO:0042592
GO:0042802
GO:0043226
GO:0048471
GO:0048856
GO:0048870
GO:0051276
GO:0055015
GO:0061024
GO:0071456
GO:0072201
GO:0090201
GO:0090343
GO:0140014
GO:1900114
GO:1900180
GO:1903243
GO:1990683
GO:2001237
HMNXSV003021995
HMNXSV003040267
HMNXSV003043843
HMNXSV003044458
Hs.77886.1.S1_3p_a_at
Hs.77886.2.S2_3p_at
Hs2.377973.4.S1_3p_s_at
ILMN_1696749
ILMN_1737394
M13452_s_at
PH_hs_0025504
g5031874_3p_a_at
Participates
as a component of
Other forms of this molecule
LMNA(1-664) [nucleoplasm]
LMNA-RAF1 fusion [cytosol]
Modified Residues
Name
Insertion of residues 279 to 648 at 568 from UniProt:P04049 RAF1
Coordinate
568
Name
O-phospho-L-serine at 621
Coordinate
621
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 338
Coordinate
338
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O4'-phospho-L-tyrosine at 341
Coordinate
341
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-threonine at 491
Coordinate
491
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 494
Coordinate
494
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Disease
Name Identifier Synonyms
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
skin melanoma DOID:8923 malignant lip melanoma, malignant ear melanoma, malignant melanoma of ear and/or external auricular canal, cutaneous melanoma, malignant melanoma of skin of trunk except scrotum, malignant neck melanoma, malignant melanoma of skin of upper limb, malignant scalp melanoma, malignant upper limb melanoma, malignant lower limb melanoma, malignant melanoma of skin of lower limb, malignant trunk melanoma
Cross References
RefSeq
OpenTargets
GeneCards
HPA
Ensembl
PRO
Pharos - Targets
GlyGen
Orphanet
PDB
Interactors (84)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P20700 LMNB1  8 0.849 10
 UniProt:P50402 EMD  4 0.799 7
 UniProt:Q9UII6 DS13B      0.781 7
 UniProt:Q03252 LMNB2      0.713 6
 UniProt:O75694 NUP155  2 0.672 6
 UniProt:Q13573 SNW1  1 0.666 4
 UniProt:P13569 CFTR  17 0.643 13
 UniProt:Q9UH99 SUN2  1 0.641 4
 UniProt:P42166 TMPO      0.629 4
 UniProt:P16104 H2AX  7 0.604 3
 UniProt:Q0D2I5-5 IFFO1      0.576 4
 UniProt:P42167 TMPO  1 0.569 4
 UniProt:P63104 YWHAZ  2 0.564 2
 UniProt:P62701 RPS4X  2 0.556 3
 UniProt:Q3B820 F161A      0.556 3
 UniProt:Q7Z699 SPRED1  2 0.556 3
 UniProt:Q7Z698 SPRED2  2 0.556 3
 UniProt:Q96MN9-2 Q96MN92      0.556 3
 UniProt:Q96LX8 ZNF597  1 0.556 3
 UniProt:Q8WXF7 ATLA1      0.556 3
 UniProt:Q86WT6-2 TRIM69      0.556 3
 UniProt:Q70EL1-9 USP54      0.556 3
 UniProt:Q9C0F3 ZNF436  1 0.556 3
 UniProt:P17024 ZNF20  1 0.556 3
 UniProt:Q9NWB1-5 RBFOX1      0.556 3
 UniProt:Q14585 ZN345      0.556 3
 UniProt:Q6ZNH5 ZN497      0.556 3
 UniProt:P60409 KRTAP10-7  1 0.556 3
 IntAct:EBI-25842396 CCSB      0.556 3
 UniProt:Q04323-2 UBXN1      0.556 3
 IntAct:EBI-10171679 386682      0.556 3
 UniProt:Q9BS31 ZNF649  1 0.556 3
 UniProt:O43309 ZSC12      0.556 3
 UniProt:Q9UNE7 STUB1  1 0.556 3
 UniProt:Q7Z3I7 ZN572      0.556 3
 UniProt:Q8IZU1 FAM9A      0.556 3
 UniProt:Q9Y4E8-2 USP15      0.556 3
 UniProt:Q96EL1 INKA1      0.556 3
 UniProt:P46379-2 BAG6      0.556 3
 UniProt:Q9HBE1-4 PATZ1      0.556 3
 UniProt:Q6H8Q1-8 ABLIM2      0.556 3
 UniProt:Q9BZ95-3 Q9BZ953      0.556 3
 UniProt:Q8N0Y2-2 ZNF444      0.556 3
 UniProt:A6H8Z2-3 A6H8Z23      0.556 3
 UniProt:O76041 NEBL      0.556 3
 UniProt:Q99612 KLF6      0.556 3
 UniProt:Q96GN5-2 CDCA7L      0.556 3
 UniProt:Q96KP6 TNIP3  1 0.556 3
 UniProt:Q8TBE0 BAHD1      0.556 3
 UniProt:Q8NEA9 GMCL2      0.556 3
 UniProt:Q12986 NFX1      0.556 3
 UniProt:Q5VYS8-5 TUT7      0.556 3
 UniProt:Q03181-2 PPARD      0.556 3
 UniProt:Q8NA54 IQUB      0.556 3
 UniProt:Q8WVD3 RNF138  1 0.556 3
 UniProt:Q8TBZ8 ZNF564  1 0.556 3
 UniProt:Q8TCX5 RHPN1  1 0.556 3
 UniProt:Q14005-2 Q140052      0.556 3
 UniProt:Q15776 ZKSCAN8  1 0.556 3
 UniProt:Q6ZNE9 RUFY4      0.556 3
 UniProt:P54274-2 TERF1      0.556 3
 UniProt:P58499 FAM3B      0.556 3
 UniProt:P10073 ZSC22      0.556 3
 UniProt:P10074 TZAP      0.556 3
 UniProt:Q13133-3 NR1H3      0.556 3
 UniProt:O75886 STAM2  2 0.556 3
 UniProt:Q6X4W1-6 NSMF      0.556 3
 IntAct:EBI-25851697 CCSB      0.556 3
 UniProt:Q3SX64 OD3L2      0.556 3
 UniProt:Q6ZN57 ZFP2  1 0.556 3
 UniProt:Q13123 RED      0.556 3
 UniProt:Q8IYM2 SLN12      0.556 3
 UniProt:Q8N488 RYBP  1 0.556 3
 UniProt:Q96DX5 ASB9  1 0.556 3
 UniProt:Q9ULD4-2 Q9ULD42      0.556 3
 UniProt:Q9Y239 NOD1  1 0.556 3
 UniProt:Q96FA3 PELI1  2 0.556 3
 UniProt:O75925 PIAS1  1 0.556 3
 UniProt:Q8WW38 ZFPM2  1 0.556 3
 UniProt:Q9D666 Sun1  1 0.528 2
 UniProt:P01106 MYC  2 0.527 3
 UniProt:P18054 ALOX12  1 0.508 4
 UniProt:Q8NC56 LEMD2  1 0.491 2
 UniProt:Q8WXH0-1 SYNE2      0.463 3
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