PLK3 phosphorylates CDC25C

Stable Identifier
R-HSA-6802973
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

PLK3 phosphorylates CDC25C at serine residue S191 within the nuclear export signal (NES). Phosphorylation of CDC25C at S191 promotes nuclear localization of CDC25C, probably by masking the NES. Nuclear accumulation of CDC25C may be important for coordination of M phase events (Bahassi et al. 2004).

Literature References
PubMed ID Title Journal Year
14968113 Cdc25C phosphorylation on serine 191 by Plk3 promotes its nuclear translocation

Bahassi, el M, Hennigan, RF, Myer, DL, Stambrook, PJ

Oncogene 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein serine/threonine kinase activity of PLK3 [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created