Reactome: A Curated Pathway Database

DCD peptide binds bacterial membrane phospholipids

Stable Identifier
R-HSA-6803047
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Dermcidin peptides, DCD1(63-109) and DCD-1L(63-110), are anionic peptides with a net negative charge of -2 at physiological pH (Paulmann M et al. 2012). Despite its negative net charge, DCD peptides possess an amphiphilic structure due to its cationic N-terminal region (Ser1 to Lys23) and its anionic C-terminal part (Asp24 to Leu48). The cationic N-terminal part is mainly responsible for the binding of DCD to the negatively charged phospholipids.

Literature References
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