Dermcidin peptides, DCD1(63-109) and DCD-1L(63-110), are anionic peptides with a net negative charge of -2 at physiological pH (Paulmann M et al. 2012). Despite its negative net charge, DCD peptides possess an amphiphilic structure due to its cationic N-terminal region (Ser1 to Lys23) and its anionic C-terminal part (Asp24 to Leu48). The cationic N-terminal part is mainly responsible for the binding of DCD to the negatively charged phospholipids.
Song, C, Weichbrodt, C, Salnikov, ES, Dynowski, M, Forsberg, BO, Bechinger, B, Steinem, C, de Groot, BL, Zachariae, U, Zeth, K
Jung, HH, Yang, ST, Sim, JY, Lee, S, Lee, JY, Kim, HH, Shin, SY, Kim, JI
Paulmann, M, Arnold, T, Linke, D, Özdirekcan, S, Kopp, A, Gutsmann, T, Kalbacher, H, Wanke, I, Schuenemann, VJ, Habeck, M, Bürck, J, Ulrich, AS, Schittek, B
Schittek, B
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