TP53 Regulates Transcription of Genes Involved in Cytochrome C Release

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Homo sapiens
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Apoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and probably BNIP3L, AIFM2, STEAP3, TRIAP1 and TP53AIP1 (Miyashita and Reed 1995, Oda et al. 2000, Samuels-Lev et al. 2001, Nakano and Vousden 2001, Sax et al. 2002, Passer et al. 2003, Bergamaschi et al. 2004, Li et al. 2004, Fei et al. 2004, Wu et al. 2004, Park and Nakamura 2005, Patel et al. 2008, Wang et al. 2012, Wilson et al. 2013), thus promoting the activation of the apoptotic pathway.

Transcriptional activation of TP53AIP1 requires phosphorylation of TP53 at serine residue S46 (Oda et al. 2000, Taira et al. 2007). Phosphorylation of TP53 at S46 is regulated by another TP53 pro-apoptotic target, TP53INP1 (Okamura et al. 2001, Tomasini et al. 2003).

Literature References
PubMed ID Title Journal Year
22766503 iASPPsv antagonizes apoptosis induced by chemotherapeutic agents in MCF-7 cells and mouse thymocytes

Tang, K, Tian, Z, Wang, L, Xing, H, Peng, L, Rao, Q, Wang, J, Li, Y, Wang, M

Biochem. Biophys. Res. Commun. 2012
11463392 PUMA, a novel proapoptotic gene, is induced by p53

Nakano, K, Vousden, KH

Mol Cell 2001
7834749 Tumor suppressor p53 is a direct transcriptional activator of the human bax gene

Miyashita, T, Reed, JC

Cell 1995
10807576 Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis

Taniguchi, T, Tokino, T, Yamashita, T, Shibue, T, Ohki, R, Oda, E, Nemoto, J, Murasawa, H, Tanaka, N

Science 2000
15273740 AMID is a p53-inducible gene downregulated in tumors

Su, T, Zhai, Z, Wu, M, Shu, HB, Tian, Y, Xu, LG

Oncogene 2004
11511362 p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis

Arakawa, H, Nakanishi, H, Nakamura, Y, Monden, M, Taya, Y, Ng, CC, Tanaka, T, Okamura, S

Mol. Cell 2001
14729977 ASPP1 and ASPP2: common activators of p53 family members

Samuels, Y, Lu, X, Jin, B, Duraisingham, S, Bergamaschi, D, Crook, T

Mol. Cell. Biol. 2004
18676979 Molecular interactions of ASPP1 and ASPP2 with the p53 protein family and the apoptotic promoters PUMA and Bax

Autore, F, Fraternali, F, Ladbury, JE, Patel, S, George, R, Nikolova, PV

Nucleic Acids Res. 2008
12851404 TP53INP1s and homeodomain-interacting protein kinase-2 (HIPK2) are partners in regulating p53 activity

Malissen, B, Tomasini, R, Carrier, A, Dusetti, NJ, Isnardon, D, Samir, AA, Cecchinelli, B, Soddu, S, Iovanna, JL, Dagorn, JC

J. Biol. Chem. 2003
15735003 p53CSV, a novel p53-inducible gene involved in the p53-dependent cell-survival pathway

Nakamura, Y, Park, WR

Cancer Res. 2005
12606722 The p53-inducible TSAP6 gene product regulates apoptosis and the cell cycle and interacts with Nix and the Myt1 kinase

Roborel de Climens, A, Cans, C, Prieur, S, Passer, BJ, Susini, L, Dausset, J, Nancy-Portebois, V, Amson, R, Bouvard, V, Morchoisne, S, Fiucci, G, Telerman, A, Tuynder, M, Crible, V, Lespagnol, A, Amzallag, N, Oren, M

Proc. Natl. Acad. Sci. U.S.A. 2003
15607964 Bnip3L is induced by p53 under hypoxia, and its knockdown promotes tumor growth

Dicker, DT, Wang, W, Buzzai, M, Wang, S, McKenna, WG, Kim, SH, Fei, P, Bernhard, EJ, Sax, JK, Burns, TF, El-Deiry, WS

Cancer Cell 2004
15126337 Apoptotic signaling pathways induced by nitric oxide in human lymphoblastoid cells expressing wild-type or mutant p53

Hanigan, CL, Robles, AI, Trudel, LJ, Hofseth, LJ, Li, CQ, Wogan, GN, Harris, CC

Cancer Res 2004
11684014 ASPP proteins specifically stimulate the apoptotic function of p53

Hsieh, JK, Trigiante, G, Crook, T, Zhong, S, Bergamaschi, D, O'Connor, DJ, Lu, X, Campargue, I, Naumovski, L, Samuels-Lev, Y

Mol. Cell 2001
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Feinstein, E, Wilson, AM, Morquette, B, Abdouh, M, Bernier, G, Unsain, N, Di Polo, A, Barker, PA

J. Neurosci. 2013
12402042 BID regulation by p53 contributes to chemosensitivity

Murphy, ME, Bernhard, E, Fei, P, Korsmeyer, SJ, Sax, JK, El-Deiry, WS

Nat. Cell Biol. 2002
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