TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain

Stable Identifier
R-HSA-6803205
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The exact mechanisms of action of several other pro-apoptotic TP53 (p53) targets, such as TP53I3 (PIG3), RABGGTA, BCL2L14, BCL6, NDRG1 and PERP, remain uncertain (Attardi et al. 2000, Guo et al. 2001, Samuels-Lev et al. 2001, Contente et al. 2002, Ihrie et al. 2003, Bergamaschi et al. 2004, Stein et al. 2004, Phan and Dalla-Favera 2004, Jen and Cheung 2005, Margalit et al. 2006, Zhang et al. 2007, Saito et al. 2009, Davies et al. 2009, Giam et al. 2012).

Literature References
PubMed ID Title Journal Year
10733530 PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family Genes Dev. 2000
11054413 Bcl-G, a novel pro-apoptotic member of the Bcl-2 family J. Biol. Chem. 2001
16249378 BCL6 is regulated by p53 through a response element frequently disrupted in B-cell non-Hodgkin lymphoma Blood 2006
15377670 NDRG1 is necessary for p53-dependent apoptosis J. Biol. Chem. 2004
23059823 Bcl-2 family member Bcl-G is not a proapoptotic protein Cell Death Dis 2012
15577913 The BCL6 proto-oncogene suppresses p53 expression in germinal-centre B cells Nature 2004
14729977 ASPP1 and ASPP2: common activators of p53 family members Mol. Cell. Biol. 2004
19549844 BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma Proc. Natl. Acad. Sci. U.S.A. 2009
17442733 p53-dependent NDRG1 expression induces inhibition of intestinal epithelial cell proliferation but not apoptosis after polyamine depletion Am. J. Physiol., Cell Physiol. 2007
11919562 A polymorphic microsatellite that mediates induction of PIG3 by p53 Nat. Genet. 2002
14614825 Perp is a mediator of p53-dependent apoptosis in diverse cell types Curr. Biol. 2003
19040420 P53 apoptosis mediator PERP: localization, function and caspase activation in uveal melanoma J. Cell. Mol. Med. 2009
16140933 Identification of novel p53 target genes in ionizing radiation response Cancer Res. 2005
11684014 ASPP proteins specifically stimulate the apoptotic function of p53 Mol. Cell 2001
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