TP53 Regulates Transcription of Caspase Activators and Caspases

Stable Identifier
R-HSA-6803207
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

TP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are involved either in the intrinsic apoptosis pathway or in the extrinsic apoptosis pathway triggerred by death receptors or the inflammation-related cell death pyroptosis (Lin et al. 2000, Robles et al. 2001, Gupta et al. 2001, MacLachlan and El-Deiry 2002, Rikhof et al. 2003, Sadasivam et al. 2005, Brough and Rothwell 2007).

Literature References
PubMed ID Title Journal Year
10973264 Pidd, a new death-domain-containing protein, is induced by p53 and promotes apoptosis

Lin, Y, Ma, W, Benchimol, S

Nat. Genet. 2000
17284521 Caspase-1-dependent processing of pro-interleukin-1beta is cytosolic and precedes cell death

Brough, D, Rothwell, NJ

J Cell Sci 2007
15580302 Caspase-1 activator Ipaf is a p53-inducible gene involved in apoptosis

Sadasivam, S, Gupta, S, Radha, V, Batta, K, Kundu, TK, Swarup, G

Oncogene 2005
11278253 Direct transcriptional activation of human caspase-1 by tumor suppressor p53

Gupta, S, Radha, V, Furukawa, Y, Swarup, G

J. Biol. Chem. 2001
12089322 Apoptotic threshold is lowered by p53 transactivation of caspase-6

MacLachlan, TK, El-Deiry, WS

Proc. Natl. Acad. Sci. U.S.A. 2002
14688482 Caspase 10 levels are increased following DNA damage in a p53-dependent manner

Rikhof, B, Corn, PG, El-Deiry, WS

Cancer Biol. Ther. 2003
11559530 APAF-1 is a transcriptional target of p53 in DNA damage-induced apoptosis

Robles, AI, Bemmels, NA, Foraker, AB, Harris, CC

Cancer Res. 2001
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