TP53 Regulates Transcription of Death Receptors and Ligands

Stable Identifier
R-HSA-6803211
Type
Pathway
Species
Homo sapiens
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Pro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). TRAIL receptors and FAS induce pro-apoptotic signaling in response to external stimuli via extrinsic apoptosis pathway (Wu et al. 1997, Takimoto et al. 2000, Guan et al. 2001, Liu et al. 2004, Ruiz de Almodovar et al. 2004, Liu et al. 2005, Schilling et al. 2009, Wilson et al. 2013). IGFBP3 is a transcriptional target of TP53 that may serve as a ligand for a novel death receptor TMEM219 (Buckbinder et al. 1995, Ingermann et al. 2010).

Literature References
PubMed ID Title Journal Year
20353938 Identification of a novel cell death receptor mediating IGFBP-3-induced anti-tumor effects in breast and prostate cancer

Ingermann, AR, Yang, YF, Han, J, Mikami, A, Garza, AE, Mohanraj, L, Fan, L, Idowu, M, Ware, JL, Kim, HS, Lee, DY, Oh, Y

J. Biol. Chem. 2010
23365256 ASPP1/2 regulate p53-dependent death of retinal ganglion cells through PUMA and Fas/CD95 activation in vivo

Wilson, AM, Morquette, B, Abdouh, M, Unsain, N, Barker, PA, Feinstein, E, Bernier, G, Di Polo, A

J. Neurosci. 2013
7566179 Induction of the growth inhibitor IGF-binding protein 3 by p53

Buckbinder, L, Talbott, R, Velasco-Miguel, S, Takenaka, I, Faha, B, Seizinger, BR, Kley, N

Nature 1995
14623878 Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) decoy receptor TRAIL-R3 is up-regulated by p53 in breast tumor cells through a mechanism involving an intronic p53-binding site

Ruiz de Almodóvar, C, Ruiz-Ruiz, C, Rodríguez, A, Ortiz-Ferrón, G, Redondo, JM, López-Rivas, A

J. Biol. Chem. 2004
11382926 Evidence that the death receptor DR4 is a DNA damage-inducible, p53-regulated gene

Guan, B, Yue, P, Clayman, GL, Sun, SY

J. Cell. Physiol. 2001
15289308 p53 upregulates death receptor 4 expression through an intronic p53 binding site

Liu, X, Yue, P, Khuri, FR, Sun, SY

Cancer Res. 2004
10777207 Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site

Takimoto, R, el-Deiry, WS

Oncogene 2000
19615968 Active transcription of the human FAS/CD95/TNFRSF6 gene involves the p53 family

Schilling, T, Schleithoff, ES, Kairat, A, Melino, G, Stremmel, W, Oren, M, Krammer, PH, Müller, M

Biochem. Biophys. Res. Commun. 2009
9326928 KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene

Wu, GS, Burns, TF, McDonald, ER, Jiang, W, Meng, R, Krantz, ID, Kao, G, Gan, DD, Zhou, JY, Muschel, R, Hamilton, SR, Spinner, NB, Markowitz, S, Wu, G, el-Deiry, WS

Nat. Genet. 1997
16230375 Decoy receptor 2 (DcR2) is a p53 target gene and regulates chemosensitivity

Liu, X, Yue, P, Khuri, FR, Sun, SY

Cancer Res. 2005
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