Reactome | MAPK14 [secretory granule lumen]

MAPK14 [secretory granule lumen]

Stable Identifier

R-HSA-6803300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

MAP kinase p38 alpha, Mitogen-activated protein kinase 14, MK14_HUMAN, p38 alpha

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External Reference Information

External Reference

UniProt:Q16539 MAPK14

Gene Names

MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

Chain

initiator methionine:, chain:2-360

Reference Genes

BioGPS Gene:1432 MAPK14

COSMIC (genes):MAPK14 MAPK14

CTD Gene:1432 MAPK14

dbSNP Gene:1432 MAPK14

ENSEMBL:ENSG00000112062 MAPK14

HGNC:6876 MAPK14

KEGG:hsa:1432 MAPK14

Monarch:1432 MAPK14

NCBI Gene:1432 MAPK14

OMIM:600289 MAPK14

UCSC:Q16539 MAPK14

Reference Transcript

Participates

as a member of

Secretory granule lumen proteins [secretory granule lumen] (Homo sapiens)

Other forms of this molecule

p-T180,Y182-MAPK14 [nucleoplasm]

p-T180,Y182-MAPK14 [cytosol]

MAPK14 [cytosol]

MAPK14 [nucleoplasm]

MAPK14 [ficolin-1-rich granule lumen]

MAPK14 [extracellular region]

Inferred To

cdc7 [secretory granule lumen] (Dictyostelium discoideum)

p38b [secretory granule lumen] (Drosophila melanogaster)

mapk14b [secretory granule lumen] (Danio rerio)

Mapk14 [secretory granule lumen] (Mus musculus)

Mapk14 [secretory granule lumen] (Rattus norvegicus)

pmk-1 [secretory granule lumen] (Caenorhabditis elegans)

Homologues of MAPK14 [secretory granule lumen] (Caenorhabditis elegans)

Homologues of MAPK14 [secretory granule lumen] (Dictyostelium discoideum)

Homologues of MAPK14 [secretory granule lumen] (Drosophila melanogaster)

p38c [secretory granule lumen] (Drosophila melanogaster)

pmk-3 [secretory granule lumen] (Caenorhabditis elegans)

mapk14 [secretory granule lumen] (Xenopus tropicalis)

p38a [secretory granule lumen] (Drosophila melanogaster)

sty1 [secretory granule lumen] (Schizosaccharomyces pombe)

gskl-2 [secretory granule lumen] (Caenorhabditis elegans)

MAPK14 [secretory granule lumen] (Bos taurus)

MAPK14 [secretory granule lumen] (Caenorhabditis elegans)

MAPK14 [secretory granule lumen] (Canis familiaris)

MAPK14 [secretory granule lumen] (Dictyostelium discoideum)

MAPK14 [secretory granule lumen] (Gallus gallus)

MAPK14 [secretory granule lumen] (Sus scrofa)

HOG1 [secretory granule lumen] (Saccharomyces cerevisiae)

pmk-2 [secretory granule lumen] (Caenorhabditis elegans)

Cross References

RefSeq

NP_620583.1, NP_001306.1, NP_620582.1, NP_620581.1

ZINC - World Drugs

MK14_HUMAN

Guide to Pharmacology - Targets

1499

OpenTargets

ENSG00000112062

ENSEMBL

ENST00000310795, ENSP00000229794, ENSG00000112062, ENSP00000308669, ENST00000229794, ENST00000229795, ENSP00000229795

ZINC - FDA approved

MK14_HUMAN

ZINC - Substances

MK14_HUMAN

ZINC - Biogenic

MK14_HUMAN

ZINC target

Q16539

PRO

Q16539

GlyGen

Q16539

PDB

3HP5, 5XYX, 4EWQ, 1WBN, 4EH3, 3FMN, 3MVM, 2LGC, 1WFC, 1ZYJ, 3ROC, 4KIN, 3HV3, 3CTQ, 4EH7, 4F9W, 5N66, 5OMG, 2BAQ, 3OC1, 6HWV, 3OBJ, 3NEW, 3OCG, 6M95, 4E5A, 4AAC, 5WJJ, 3IW8, 3ODY, 3GI3, 2YIX, 3D83, 5MTY, 3L8S, 5ETI, 2QD9, 4L8M, 3O8P, 3FKN, 3IPH, 3S4Q, 1W84, 3HEC, 5N65, 3FMK, 3L8X, 3FLZ, 3MPT, 6HWU, 3MW1, 3UVP, 4AA4, 3GCP, 3GFE, 4E5B, 1YQJ, 3NNW, 3ODZ, 3BX5, 3KQ7, 2Y8O, 3FMM, 3FMH, 4EHV, 3MVL, 2ONL, 5N63, 4EH6, 3IW6, 3OEF, 2YIS, 3GCV, 6TCA, 4A9Y, 8A8M, 3LFE, 3FKL, 4E6A, 6QE1, 3GC7, 3E92, 3MH2, 3HUB, 2YIW, 3U8W, 5N67, 3FC1, 4ZTH, 5ETF, 2GFS, 5TCO, 1R39, 3LFD, 3GCU, 3O8U, 3NNU, 4GEO, 5XYY, 3C5U, 1WBS, 5ETA, 3FLQ, 3IW7, 1WBV, 3DT1, 3LFF, 3FLY, 3FMJ, 1BL6, 9CJ3, 3E93, 3MH3, 6ANL, 3MGY, 6QDZ, 3HUC, 6QYX, 3KF7, 3HV6, 1R3C, 1IAN, 1M7Q, 3NWW, 3OD6, 3NNV, 3FSF, 6OHD, 1OUY, 3LHJ, 1WBO, 3ZYA, 3HEG, 2FSO, 3FLN, 1KV1, 1OUK, 8VXE, 3LFC, 2RG6, 3FLW, 3ITZ, 3HV5, 3FI4, 5TBE, 4F9Y, 3MH0, 3BV3, 3GCS, 3HP2, 1A9U, 5ETC, 4DLI, 6SFK, 2BAK, 4R3C, 6RFO, 9CJ5, 4AA0, 3HA8, 4EH5, 3IW5, 5N64, 2ZAZ, 6M9L, 3S3I, 3O8T, 9CJ2, 1WBW, 2RG5, 2OKR, 1BL7, 3OBG, 3ZSH, 3UVR, 3MH1, 3ZS5, 5OMH, 4EH2, 1DI9, 1BMK, 3HRB, 3RIN, 3MPA, 5MZ3, 3HL7, 4DLJ, 2BAJ, 8X3M, 6SFO, 6ZWP, 3HV7, 4EH4, 3FLS, 1ZZ2, 2NPQ, 2FSM, 5O8U, 1W7H, 1WBT, 3K3I, 3ZSI, 1ZZL, 1W83, 3LFA, 3HV4, 5O8V, 4KIP, 4EH8, 5ML5, 3HLL, 3FL4, 4AA5, 3GCQ, 2ZB0, 6SFJ, 3NNX, 3QUD, 2BAL, 3PG3, 6ZQS, 2I0H, 9CJ4, 5MTX, 1KV2, 2FST, 2FSL, 6HWT, 3FKO, 4E6C, 3K3J, 1OZ1, 3LFB, 1W82, 9CJ1, 4FA2, 3D7Z, 4E8A, 5N68, 3FML, 3UVQ, 3ZSG, 3BV2, 4EH9, 4KIQ, 3HVC, 2ZB1, 1OVE, 6SFI, 3QUE, 3FSK, 3DS6

ZINC - Investigational

MK14_HUMAN

ZINC - Metabolites

MK14_HUMAN

IntEnz

2.7.11.24

GeneCards

MAPK14

HPA

ENSG00000112062-MAPK14

Pharos - Targets

Q16539

ZINC - Predictions - Purchasable

MK14_HUMAN

HMDB Protein

HMDBP01516

Interactors (39)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49137 MAPKAPK2	5	MAPKAPK2 [nucleoplasm] (R-HSA-450235) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) MAPKAPK2 [cytosol] (R-HSA-187743)	0.936	16
UniProt:Q16644 MAPKAPK3	4	MAPKAPK3 [nucleoplasm] (R-HSA-450218) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723) MAPKAPK3 [cytosol] (R-HSA-187764)	0.922	16
UniProt:O75676 RPS6KA4	1	RPS6KA4 [cytosol] (R-HSA-772527)	0.869	10
UniProt:P46734 MAP2K3	3	p-S218,T222-MAP2K3 [nucleoplasm] (R-HSA-450229) p-S218,T222-MAP2K3 [cytosol] (R-HSA-167955) MAP2K3 [cytosol] (R-HSA-168051)	0.802	7
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.798	7
UniProt:O75147 OBSL1	1	OBSL1 [cytosol] (R-HSA-8955929)	0.788	5
UniProt:Q9HBH9 MKNK2			0.788	5
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.779	6
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.767	4
UniProt:Q8NEM7 SUPT20H	1	SUPT20H [nucleoplasm] (R-HSA-3662286)	0.756	5
UniProt:Q9BY84 DUSP16	3	DUSP16 [cytosol] (R-HSA-5675336) DUSP16 [nucleoplasm] (R-HSA-5675337) Ac-55-DUSP16 [cytosol] (R-HSA-9636576)	0.738	4
UniProt:O43257 ZNHI1			0.72	7
UniProt:Q15750 TAB1	6	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238) TAB1(1-444) [cytosol] (R-HSA-9729751) TAB1(1-132) [cytosol] (R-HSA-9729698) TAB1(133-504) [cytosol] (R-HSA-9729724) TAB1(445-504) [cytosol] (R-HSA-9729691)	0.713	4
UniProt:P27361 MAPK3	6	p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295)	0.691	5
UniProt:Q15256 PTPRR			0.664	4
UniProt:O75582 RPS6KA5	3	p-S212,S360,S376,T581-RPS6KA5 [nucleoplasm] (R-HSA-198683) RPS6KA5 [nucleoplasm] (R-HSA-198657) RPS6KA5 [cytosol] (R-HSA-772525)	0.659	4
UniProt:Q6PJG2 MDEAS			0.659	3
UniProt:P46940 IQGAP1	3	IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [plasma membrane] (R-HSA-381681)	0.643	4
UniProt:Q9H0W5 CCDC8	1	CCDC8 [cytosol] (R-HSA-8955915)	0.643	3
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.623	4
UniProt:Q16829 DUSP7	2	DUSP7 [cytosol] (R-HSA-5675346) DUSP7 [nucleoplasm] (R-HSA-203791)	0.59	2
UniProt:P52564 MAP2K6	3	p-S207,T211-MAP2K6 [nucleoplasm] (R-HSA-450258) p-S207,T211-MAP2K6 [cytosol] (R-HSA-206255) MAP2K6 [cytosol] (R-HSA-167998)	0.564	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q9H869 YYAP1			0.553	2
UniProt:Q8IW41 MAPKAPK5	5	p-T182 MAPKAPK5 [cytosol] (R-HSA-5687004) p-S115 MAPKAPK5 [cytosol] (R-HSA-5687028) p-S115 MAPKAPK5 [nucleoplasm] (R-HSA-5687026) MAPKAPK5 [nucleoplasm] (R-HSA-2562517) p-T182-MAPKAPK5 [nucleoplasm] (R-HSA-3239018)	0.547	2
UniProt:Q14814 MEF2D	1	MEF2D [nucleoplasm] (R-HSA-445328)	0.547	2
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.547	2
UniProt:P68104 EEF1A1	7	EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [secretory granule lumen] (R-HSA-6801479) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.547	3
UniProt:P13639 EEF2	10	EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	2
UniProt:Q5VYV7 SLX4I			0.527	3
UniProt:Q14999 CUL7	1	CUL7 [cytosol] (R-HSA-535534)	0.527	2
UniProt:Q96RR4 CAMKK2	4	p-CAMKK2 [nucleoplasm] (R-HSA-9618968) CAMKK2 [nucleoplasm] (R-HSA-5336483) p-CAMKK2 [cytosol] (R-HSA-9619358) CAMKK2 [cytosol] (R-HSA-9619231)	0.527	2
UniProt:Q96CC6 RHDF1			0.527	2
UniProt:Q15170 TCAL1			0.527	2
UniProt:P78368 CSNK1G2	2	CSNK1G2 [plasma membrane] (R-HSA-205718) CSNK1G2 [cytosol] (R-HSA-429696)	0.527	3
UniProt:P51784 USP11	1	USP11 [cytosol] (R-HSA-391303)	0.527	2
UniProt:Q07352 ZFP36L1	3	p-S54,S92,S203-p-ZFP36L1 [cytosol] (R-HSA-450384) ZFP36L1 [cytosol] (R-HSA-450547) p-S92,S203-ZFP36L1 [cytosol] (R-HSA-450618)	0.508	2
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.508	2
UniProt:Q969H0 FBXW7	1	FBXW7 [cytosol] (R-HSA-391304)	0.471	5

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