Reactome | MAPK14 [secretory granule lumen]

MAPK14 [secretory granule lumen]

Stable Identifier

R-HSA-6803300

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

secretory granule lumen

Synonyms

MAP kinase p38 alpha, Mitogen-activated protein kinase 14, MK14_HUMAN, p38 alpha

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External Reference Information

External Reference

UniProt:Q16539 MAPK14

Gene Names

MAPK14, CSBP, CSBP1, CSBP2, CSPB1, MXI2, SAPK2A

Chain

initiator methionine:1, chain:2-360

Reference Genes

BioGPS Gene:1432 MAPK14

COSMIC (genes):MAPK14 MAPK14

CTD Gene:1432 MAPK14

dbSNP Gene:1432 MAPK14

ENSEMBL:ENSG00000112062 MAPK14

HGNC:6876 MAPK14

KEGG Gene (Homo sapiens):1432 MAPK14

Monarch:1432 MAPK14

NCBI Gene:1432 MAPK14

OMIM:600289 MAPK14

UCSC:Q16539 MAPK14

Reference Transcript

Other Identifiers

0000380088

0005910181

11717276_s_at

11742204_a_at

11742487_a_at

11749297_a_at

11753885_a_at

1432

1671_s_at

17007884

1999_s_at

202530_at

210449_x_at

211087_3p_x_at

211087_x_at

211561_x_at

232876_at

2904878

2904879

2904884

2904885

2904889

2904891

2904892

2904894

2904896

2904907

2904910

2904913

2904914

2904919

2904920

2904921

2904922

2904923

2904924

2904925

2904930

2904932

37733_at

78240_at

8119000

A_14_P111428

A_23_P426292

A_24_P283288

A_24_P397566

GE492524

GE57735

GO:0000003

GO:0000077

GO:0000166

GO:0000187

GO:0000902

GO:0000922

GO:0001502

GO:0001525

GO:0001890

GO:0002062

GO:0002376

GO:0002720

GO:0003674

GO:0004672

GO:0004674

GO:0004707

GO:0004708

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0005856

GO:0005975

GO:0006006

GO:0006355

GO:0006357

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006913

GO:0006915

GO:0006935

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0007166

GO:0007178

GO:0007265

GO:0007267

GO:0007519

GO:0007568

GO:0008134

GO:0008150

GO:0008219

GO:0008283

GO:0009056

GO:0009058

GO:0010468

GO:0010628

GO:0010759

GO:0010831

GO:0015031

GO:0016192

GO:0016301

GO:0016310

GO:0016607

GO:0016740

GO:0018105

GO:0019395

GO:0019899

GO:0019903

GO:0030154

GO:0030278

GO:0030316

GO:0031281

GO:0031410

GO:0031663

GO:0032495

GO:0032496

GO:0032735

GO:0034641

GO:0034655

GO:0034774

GO:0035331

GO:0035556

GO:0035924

GO:0035994

GO:0038066

GO:0040007

GO:0040011

GO:0042307

GO:0042592

GO:0042770

GO:0043167

GO:0043226

GO:0043312

GO:0044281

GO:0045648

GO:0045663

GO:0045944

GO:0046326

GO:0048010

GO:0048273

GO:0048646

GO:0048856

GO:0048870

GO:0051090

GO:0051146

GO:0051149

GO:0051525

GO:0055085

GO:0060045

GO:0070935

GO:0071222

GO:0071223

GO:0071356

GO:0071479

GO:0090090

GO:0090336

GO:0090400

GO:0098586

GO:1900015

GO:1901741

GO:1901796

GO:1904813

GO:1905050

GO:2000379

Hs.258010.0.S1_3p_at

ILMN_1737627

ILMN_1788002

ILMN_2388090

L35253_s_at

L35263_at

PH_hs_0004571

PH_hs_0020050

TC06000523.hg

g405742_3p_s_at

g4503068_3p_at

g7109716_3p_a_at

Participant Of

hasMember

Secretory granule lumen proteins [secretory granule lumen]

Other forms of this molecule

MAPK14 [ficolin-1-rich granule lumen]

MAPK14 [extracellular region]

MAPK14 [nucleoplasm]

MAPK14 [cytosol]

p-T180,Y182-MAPK14 [cytosol]

p-T180,Y182-MAPK14 [nucleoplasm]

Inferred To

SLT2 [secretory granule lumen] (Saccharomyces cerevisiae)

spm1 [secretory granule lumen] (Schizosaccharomyces pombe)

SMK1 [secretory granule lumen] (Saccharomyces cerevisiae)

p38b [secretory granule lumen] (Drosophila melanogaster)

mapk14b [secretory granule lumen] (Danio rerio)

Mapk14 [secretory granule lumen] (Mus musculus)

Mapk14 [secretory granule lumen] (Rattus norvegicus)

pmk-1 [secretory granule lumen] (Caenorhabditis elegans)

Homologues of MAPK14 [secretory granule lumen] (Danio rerio)

Homologues of MAPK14 [secretory granule lumen] (Dictyostelium discoideum)

Homologues of MAPK14 [secretory granule lumen] (Plasmodium falciparum)

Homologues of MAPK14 [secretory granule lumen] (Saccharomyces cerevisiae)

Homologues of MAPK14 [secretory granule lumen] (Schizosaccharomyces pombe)

sty1 [secretory granule lumen] (Schizosaccharomyces pombe)

mapk14a [secretory granule lumen] (Danio rerio)

MAPK14 [secretory granule lumen] (Bos taurus)

MAPK14 [secretory granule lumen] (Canis familiaris)

MAPK14 [secretory granule lumen] (Dictyostelium discoideum)

MAPK14 [secretory granule lumen] (Gallus gallus)

MAPK14 [secretory granule lumen] (Plasmodium falciparum)

MAPK14 [secretory granule lumen] (Sus scrofa)

MAPK14 [secretory granule lumen] (Xenopus tropicalis)

erkA [secretory granule lumen] (Dictyostelium discoideum)

HOG1 [secretory granule lumen] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_001306.1, NP_620581.1, NP_620582.1, NP_620583.1

ZINC - World Drugs

MK14_HUMAN

OpenTargets

ENSG00000112062

ZINC - FDA approved

MK14_HUMAN

ZINC - Substances

MK14_HUMAN

ZINC target

Q16539

ZINC - Biogenic

MK14_HUMAN

PRO

Q16539

PDB

1WBN, 1M7Q, 1ZYJ, 3HV3, 3E92, 3DT1, 1BL7, 4E6C, 4L8M, 4E8A, 3ZS5, 4KIP, 3GCS, 3LFE, 1OZ1, 3HA8, 4EH7, 3BV3, 3FMN, 3FKN, 3FML, 5ETF, 3MVL, 2RG6, 3IW6, 3LFB, 3MH0, 3HL7, 1WFC, 2ONL, 3ZSG, 3OBG, 2Y8O, 2YIX, 5N64, 3S4Q, 4EHV, 1WBW, 5MZ3, 2NPQ, 1DI9, 3ODY, 2BAK, 2ZAZ, 3GFE, 3L8X, 6SFK, 3GC7, 3OC1, 6HWV, 1KV1, 5XYX, 1W83, 3FLZ, 3IW5, 3UVR, 3K3I, 4EH8, 2OKR, 3FLN, 3FSF, 3QUD, 5TBE, 6QE1, 3MH3, 1R39, 3D83, 6M9L, 4E5B, 3OCG, 4EWQ, 3UVP, 6HWT, 5ETA, 3FC1, 3FLW, 3HRB, 4KIQ, 3GCU, 6QYX, 1W7H, 3HLL, 3FKO, 3ZSI, 1WBT, 3HV6, 3LFC, 3IW8, 3FMM, 2YIS, 5TCO, 3NNW, 3BX5, 4EH3, 3ZSH, 3HUB, 3U8W, 3FMJ, 3LFA, 4EH4, 3PG3, 3FI4, 4DLJ, 5N65, 5O8V, 6TCA, 3GCP, 5OMG, 6SFI, 2LGC, 4E5A, 1OUY, 1A9U, 4FA2, 3MPT, 3NEW, 1KV2, 1YQJ, 6SFO, 3IW7, 4AA5, 3GI3, 2FSO, 4F9W, 3ZYA, 4EH9, 4EH2, 3FMH, 4R3C, 1BMK, 5ML5, 5OMH, 4GEO, 1R3C, 3RIN, 3LHJ, 3LFF, 6HWU, 2QD9, 5N68, 3FSK, 2FSL, 3NNX, 3CTQ, 1WBO, 6ANL, 3MH1, 5MTX, 3GCQ, 3DS6, 1WBV, 5N63, 3HP2, 3HV7, 3HV4, 3FMK, 3NNU, 3ITZ, 2YIW, 6SFJ, 5N66, 2ZB0, 5WJJ, 1IAN, 4DLI, 3QUE, 2BAL, 3FLQ, 2FST, 3L8S, 3OBJ, 3O8T, 3FKL, 5ETI, 1W84, 3FLY, 3ODZ, 3E93, 4AAC, 5XYY, 4EH5, 3UVQ, 3NWW, 1BL6, 4F9Y, 3GCV, 3C5U, 3O8P, 4ZTH, 3FL4, 4E6A, 4A9Y, 3MGY, 2RG5, 3HUC, 4EH6, 2FSM, 1WBS, 3HP5, 3LFD, 3MW1, 5MTY, 3BV2, 3MH2, 5ETC, 4AA4, 3NNV, 2GFS, 5O8U, 3KF7, 1ZZL, 3HEG, 3HV5, 4AA0, 2ZB1, 5N67, 3HEC, 3IPH, 2BAJ, 3KQ7, 3ROC, 2BAQ, 3HVC, 3D7Z, 3MVM, 1ZZ2, 6OHD, 1OVE, 3FLS, 1OUK, 3S3I, 1W82, 6M95, 3K3J, 3O8U, 3OEF, 3OD6, 2I0H, 6RFO, 6QDZ, 3MPA, 4KIN

ZINC - Investigational

MK14_HUMAN

ZINC - Metabolites

MK14_HUMAN

HPA

ENSG00000112062-MAPK14

GeneCards

Q16539

Ensembl

ENST00000310795, ENSP00000229794, ENSG00000112062, ENSP00000308669, ENSP00000229795, ENST00000229795, ENST00000229794

ZINC - Predictions - Purchasable

MK14_HUMAN

HMDB Protein

HMDBP01516

Interactors (24)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P49137 MAPKAPK2	5	p-T222,S272-MAPKAPK2 [nucleoplasm] (R-HSA-199936) MAPKAPK2 [cytosol] (R-HSA-187743) p-S272,T222,T334-MAPKAPK2 [cytosol] (R-HSA-187760) p-T222,S272,T334-MAPKAPK2 [nucleoplasm] (R-HSA-450268) MAPKAPK2 [nucleoplasm] (R-HSA-450235)	0.912	9
UniProt:Q16644 MAPKAPK3	4	p-S,2T-MAPKAPK3 [cytosol] (R-HSA-187723) MAPKAPK3 [cytosol] (R-HSA-187764) p-S,2T-MAPKAPK3 [nucleoplasm] (R-HSA-450359) MAPKAPK3 [nucleoplasm] (R-HSA-450218)	0.891	8
UniProt:O75676 RPS6KA4	1	RPS6KA4 [cytosol] (R-HSA-772527)	0.779	6
UniProt:Q8NEM7 SUPT20H	1	SUPT20H [nucleoplasm] (R-HSA-3662286)	0.756	5
UniProt:Q15750 TAB1	2	TAB1 [cytosol] (R-HSA-167923) TAB1 [endosome membrane] (R-HSA-450238)	0.729	4
UniProt:O43257 ZNHI1			0.72	7
UniProt:P28562 DUSP1	1	DUSP1 [nucleoplasm] (R-HSA-203796)	0.704	3
UniProt:P27361 MAPK3	6	p-T202-MAPK3 [cytosol] (R-HSA-9635775) MAPK3 [endoplasmic reticulum lumen] (R-HSA-9636295) MAPK3 [nucleoplasm] (R-HSA-73724) p-T202,Y204-MAPK3 [nucleoplasm] (R-HSA-112359) p-T202,Y204-MAPK3 [cytosol] (R-HSA-109842) MAPK3 [cytosol] (R-HSA-59284)	0.704	5
UniProt:Q9HBH9 MKNK2			0.678	3
UniProt:P46734 MAP2K3	3	p-S189,T193-MAP2K3 [cytosol] (R-HSA-167955) MAP2K3 [cytosol] (R-HSA-168051) p-S189,T193-MAP2K3 [nucleoplasm] (R-HSA-450229)	0.669	4
UniProt:Q9BUB5 MKNK1	1	p-T250,T255,T385,S437-MKNK1 [cytosol] (R-HSA-947860)	0.659	3
UniProt:P06400 RB1	394	RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288) RB1 E209* [cytosol] (R-HSA-9661776) RB1 S618* [cytosol] (R-HSA-9662240) RB1 S463* [cytosol] (R-HSA-9662241) RB1 K720* [cytosol] (R-HSA-9662269) RB1 K429* [cytosol] (R-HSA-9662270) RB1 K652* [cytosol] (R-HSA-9662271) RB1 K715* [cytosol] (R-HSA-9662264) RB1 K615* [cytosol] (R-HSA-9662266) RB1 K412* [cytosol] (R-HSA-9662261) RB1 S567* [cytosol] (R-HSA-9662218) RB1 S807* [cytosol] (R-HSA-9662212) RB1 R467* [cytosol] (R-HSA-9662213) RB1 S834* [cytosol] (R-HSA-9662210) RB1 S576* [cytosol] (R-HSA-9662237) RB1 S758* [cytosol] (R-HSA-9662232) RB1 R7Pfs24 [cytosol] (R-HSA-9686292) RB1 S443 [cytosol] (R-HSA-9662230) RB1 S648* [cytosol] (R-HSA-9662224) RB1 S391* [cytosol] (R-HSA-9662225) RB1 S829* [cytosol] (R-HSA-9662226) RB1 D32Tfs33 [cytosol] (R-HSA-9688044) RB1 Y651Ifs7 [cytosol] (R-HSA-9688045) RB1 K143Mfs19 [cytosol] (R-HSA-9688046) RB1 V754Sfs4 [cytosol] (R-HSA-9688047) RB1 L44Rfs4 [cytosol] (R-HSA-9688040) RB1 E97Gfs13 [cytosol] (R-HSA-9688041) RB1 I679* [cytosol] (R-HSA-9688042) RB1 W195* [cytosol] (R-HSA-9689579) RB1 G100Efs11 [cytosol] (R-HSA-9688043) RB1 S648Tfs4 [cytosol] (R-HSA-9688036) RB1 H281Qfs6 [cytosol] (R-HSA-9688037) RB1 Q384 [cytosol] (R-HSA-9661925) RB1 S182Yfs2 [cytosol] (R-HSA-9688038) RB1 L343Sfs3 [cytosol] (R-HSA-9688039) RB1 L337Wfs12 [cytosol] (R-HSA-9688032) RB1 S318 [cytosol] (R-HSA-9688033) RB1 N627Mfs16 [cytosol] (R-HSA-9688034) RB1 N290Kfs20 [cytosol] (R-HSA-9688035) RB1 F299Lfs4 [cytosol] (R-HSA-9688060) RB1 Q637 [cytosol] (R-HSA-9662460) RB1 L76* [cytosol] (R-HSA-9688061) RB1 Q762* [cytosol] (R-HSA-9662461) RB1 Y655Lfs4 [cytosol] (R-HSA-9688062) RB1 N480Kfs13 [cytosol] (R-HSA-9688063) RB1 Q444* [cytosol] (R-HSA-9662463) RB1 T77Lfs34 [cytosol] (R-HSA-9688056) RB1 E747Gfs3 [cytosol] (R-HSA-9688057) RB1 M825* [cytosol] (R-HSA-9688058) RB1 L649Ffs11 [cytosol] (R-HSA-9688059) RB1 N472Ifs6 [cytosol] (R-HSA-9688052) RB1 Y813Kfs12 [cytosol] (R-HSA-9688053) RB1 I324Mfs17 [cytosol] (R-HSA-9688054) RB1 M460Ifs3 [cytosol] (R-HSA-9688055) RB1 Y655Ifs3 [cytosol] (R-HSA-9688048) RB1 L769Cfs41 [cytosol] (R-HSA-9688049) RB1 P28Lfs37 [cytosol] (R-HSA-9688050) RB1 E677Dfs19 [cytosol] (R-HSA-9688051) RB1 P370Lfs10 [cytosol] (R-HSA-9688012) RB1 N593Tfs11 [cytosol] (R-HSA-9688013) RB1 K329 [cytosol] (R-HSA-9661901) RB1 S249Ffs22 [cytosol] (R-HSA-9688014) RB1 K240 [cytosol] (R-HSA-9661902) RB1 L199Ffs4 [cytosol] (R-HSA-9688015) RB1 P253Gfs5 [cytosol] (R-HSA-9688008) RB1 K289* [cytosol] (R-HSA-9661896) RB1 S360Pfs2 [cytosol] (R-HSA-9688009) RB1 E323Kfs9 [cytosol] (R-HSA-9688010) RB1 L326* [cytosol] (R-HSA-9688011) RB1 P808Kfs12 [cytosol] (R-HSA-9688004) RB1 D584Nfs2 [cytosol] (R-HSA-9688005) RB1 N406Kfs4 [cytosol] (R-HSA-9688006) RB1 K417Wfs23 [cytosol] (R-HSA-9688007) RB1 L797Ffs18 [cytosol] (R-HSA-9688000) RB1 Q266Hfs2 [cytosol] (R-HSA-9688001) RB1 R255* [cytosol] (R-HSA-9661889) RB1 K4* [cytosol] (R-HSA-9661377) RB1 P641Afs12 [cytosol] (R-HSA-9688002) RB1 V450Sfs13 [cytosol] (R-HSA-9688003) RB1 K524Rfs28 [cytosol] (R-HSA-9688028) RB1 E280 [cytosol] (R-HSA-9661916) RB1 M825Ifs13 [cytosol] (R-HSA-9688029) RB1 M761Nfs21 [cytosol] (R-HSA-9688030) RB1 A11Rfs20 [cytosol] (R-HSA-9688031) RB1 E275 [cytosol] (R-HSA-9661919) RB1 A635Gfs6 [cytosol] (R-HSA-9688024) RB1 Q266 [cytosol] (R-HSA-9661912) RB1 I66Yfs11 [cytosol] (R-HSA-9688025) RB1 Q257 [cytosol] (R-HSA-9661913) RB1 P39Rfs26 [cytosol] (R-HSA-9688026) RB1 T664Nfs4 [cytosol] (R-HSA-9688027) RB1 Y771Lfs24 [cytosol] (R-HSA-9688020) RB1 R320Dfs12 [cytosol] (R-HSA-9688021) RB1 E282* [cytosol] (R-HSA-9661909) RB1 L277Pfs9 [cytosol] (R-HSA-9688022) RB1 I124 [cytosol] (R-HSA-9688023) RB1 N803Tfs7 [cytosol] (R-HSA-9688016) RB1 M386Ifs11 [cytosol] (R-HSA-9688017) RB1 E72Vfs34 [cytosol] (R-HSA-9688018) RB1 R150Kfs7 [cytosol] (R-HSA-9688019) RB1 L743* [cytosol] (R-HSA-9687980) RB1 R7Efs58 [cytosol] (R-HSA-9687981) RB1 T140Nfs6 [cytosol] (R-HSA-9687982) RB1 D479Efs16 [cytosol] (R-HSA-9687983) RB1 L199 [cytosol] (R-HSA-9661871) RB1 G801* [cytosol] (R-HSA-9662377) RB1 S215* [cytosol] (R-HSA-9661866) RB1 G435* [cytosol] (R-HSA-9662368) RB1 G581* [cytosol] (R-HSA-9662369) RB1 L134* [cytosol] (R-HSA-9687996) RB1 Y529Lfs26 [cytosol] (R-HSA-9687997) RB1 S816Qfs10 [cytosol] (R-HSA-9687998) RB1 E693Nfs3 [cytosol] (R-HSA-9687999) RB1 D346Rfs4 [cytosol] (R-HSA-9687992) RB1 Q35* [cytosol] (R-HSA-9661368) RB1 I806Lfs10 [cytosol] (R-HSA-9687993) RB1 E54 [cytosol] (R-HSA-9661369) RB1 L199Yfs2 [cytosol] (R-HSA-9687994) RB1 E48 [cytosol] (R-HSA-9661370) RB1 N854* [cytosol] (R-HSA-9687995) RB1 W75* [cytosol] (R-HSA-9661371) RB1 L389Ffs3 [cytosol] (R-HSA-9687988) RB1 S230 [cytosol] (R-HSA-9661876) RB1 H483Sfs10 [cytosol] (R-HSA-9687989) RB1 S842 [cytosol] (R-HSA-9687990) RB1 W78* [cytosol] (R-HSA-9661366) RB1 G449Efs8 [cytosol] (R-HSA-9687991) RB1 K63 [cytosol] (R-HSA-9661367) RB1 K537Nfs14 [cytosol] (R-HSA-9687984) RB1 L206 [cytosol] (R-HSA-9661872) RB1 K63Rfs38 [cytosol] (R-HSA-9687985) RB1 P732Lfs12 [cytosol] (R-HSA-9687986) RB1 L158* [cytosol] (R-HSA-9661874) RB1 A562Hfs49 [cytosol] (R-HSA-9687987) RB1 E72 [cytosol] (R-HSA-9661363) RB1 G540Afs3 [cytosol] (R-HSA-9688172) RB1 N328Ifs4 [cytosol] (R-HSA-9688173) RB1 E843* [cytosol] (R-HSA-9662573) RB1 L385* [cytosol] (R-HSA-9688174) RB1 E464* [cytosol] (R-HSA-9662574) RB1 N123Tfs2 [cytosol] (R-HSA-9688175) RB1 E112Dfs6 [cytosol] (R-HSA-9688168) RB1 E748* [cytosol] (R-HSA-9662568) RB1 M148Ifs8 [cytosol] (R-HSA-9688169) RB1 R661 [cytosol] (R-HSA-9688170) RB1 Y453* [cytosol] (R-HSA-9688164) RB1 K95* [cytosol] (R-HSA-9661540) RB1 M484Vfs8 [cytosol] (R-HSA-9688165) RB1 E533 [cytosol] (R-HSA-9662565) RB1 G86* [cytosol] (R-HSA-9661541) RB1 V654Sfs14 [cytosol] (R-HSA-9688166) RB1 E747 [cytosol] (R-HSA-9662566) RB1 E79* [cytosol] (R-HSA-9661542) RB1 C553Wfs53 [cytosol] (R-HSA-9688167) RB1 E677 [cytosol] (R-HSA-9662567) RB1 K96* [cytosol] (R-HSA-9661543) RB1 C102Yfs7 [cytosol] (R-HSA-9688160) RB1 E737 [cytosol] (R-HSA-9662560) RB1 E97* [cytosol] (R-HSA-9661536) RB1 R579Qfs29 [cytosol] (R-HSA-9688161) RB1 A525Pfs7 [cytosol] (R-HSA-9688162) RB1 L542Kfs11 [cytosol] (R-HSA-9688163) RB1 F482Sfs10 [cytosol] (R-HSA-9688188) RB1 L797* [cytosol] (R-HSA-9688189) RB1 P250Afs16 [cytosol] (R-HSA-9688190) RB1 S194Ffs7 [cytosol] (R-HSA-9688191) RB1 N623Qfs15 [cytosol] (R-HSA-9688184) RB1 T9Rfs56 [cytosol] (R-HSA-9688185) RB1 Y813Qfs10 [cytosol] (R-HSA-9688187) RB1 I768Cfs23 [cytosol] (R-HSA-9688180) RB1 L477Mfs17 [cytosol] (R-HSA-9688181) RB1 E675 [cytosol] (R-HSA-9662581) RB1 V654Cfs4 [cytosol] (R-HSA-9688182) RB1 F650Lfs5 [cytosol] (R-HSA-9688183) RB1 P39Sfs10 [cytosol] (R-HSA-9688176) RB1 H281Sfs2 [cytosol] (R-HSA-9688177) RB1 E551* [cytosol] (R-HSA-9662577) RB1 C61Vfs4 [cytosol] (R-HSA-9688178) RB1 D145Ifs8 [cytosol] (R-HSA-9688179) RB1 M148Hfs9 [cytosol] (R-HSA-9688140) RB1 E837 [cytosol] (R-HSA-9662540) RB1 L158Mfs19 [cytosol] (R-HSA-9688141) RB1 L832Ffs5 [cytosol] (R-HSA-9688142) RB1 E440* [cytosol] (R-HSA-9662542) RB1 D224Afs40 [cytosol] (R-HSA-9688136) RB1 P822Qfs4 [cytosol] (R-HSA-9688137) RB1 M148Vfs8 [cytosol] (R-HSA-9688138) RB1 L670Cfs7 [cytosol] (R-HSA-9688139) RB1 E465* [cytosol] (R-HSA-9662532) RB1 S414Kfs14 [cytosol] (R-HSA-9688133) RB1 K548Nfs3 [cytosol] (R-HSA-9688134) RB1 L135Tfs5 [cytosol] (R-HSA-9688135) RB1 Q207Tfs5 [cytosol] (R-HSA-9688128) RB1 Q384Tfs11 [cytosol] (R-HSA-9688129) RB1 L797Ffs14 [cytosol] (R-HSA-9688130) RB1 P232Rfs4 [cytosol] (R-HSA-9688131) RB1 T497Hfs22 [cytosol] (R-HSA-9688156) RB1 E817* [cytosol] (R-HSA-9662556) RB1 N367* [cytosol] (R-HSA-9688157) RB1 L809Rfs17 [cytosol] (R-HSA-9688158) RB1 E693 [cytosol] (R-HSA-9662558) RB1 K80* [cytosol] (R-HSA-9661534) RB1 W99Lfs11 [cytosol] (R-HSA-9688159) RB1 A15Pfs3 [cytosol] (R-HSA-9688152) RB1 Y239Lfs25 [cytosol] (R-HSA-9688153) RB1 D571Lfs41 [cytosol] (R-HSA-9688154) RB1 N186Ifs6 [cytosol] (R-HSA-9688155) RB1 E837Dfs12 [cytosol] (R-HSA-9688148) RB1 E672* [cytosol] (R-HSA-9662548) RB1 H483Yfs9 [cytosol] (R-HSA-9688149) RB1 R775Gfs35 [cytosol] (R-HSA-9688150) RB1 E580* [cytosol] (R-HSA-9662550) RB1 G617Rfs36 [cytosol] (R-HSA-9688151) RB1 E492 [cytosol] (R-HSA-9662551) RB1 A333Ffs13 [cytosol] (R-HSA-9688144) RB1 L564Sfs47 [cytosol] (R-HSA-9688145) RB1 D156Vfs19 [cytosol] (R-HSA-9688147) RB1 C438Vfs19 [cytosol] (R-HSA-9688108) RB1 C278* [cytosol] (R-HSA-9688109) RB1 E209Vfs3 [cytosol] (R-HSA-9688110) RB1 T116Lfs8 [cytosol] (R-HSA-9688111) RB1 R698Afs22 [cytosol] (R-HSA-9688104) RB1 V419 [cytosol] (R-HSA-9688105) RB1 I415Nfs13 [cytosol] (R-HSA-9688106) RB1 Y173Ffs11 [cytosol] (R-HSA-9688107) RB1 N133Tfs3 [cytosol] (R-HSA-9688100) RB1 M695Rfs10 [cytosol] (R-HSA-9688101) RB1 R418Sfs9 [cytosol] (R-HSA-9688102) RB1 Q689 [cytosol] (R-HSA-9662502) RB1 A74Efs4 [cytosol] (R-HSA-9688103) RB1 W99Yfs5 [cytosol] (R-HSA-9688096) RB1 G442Dfs15 [cytosol] (R-HSA-9688097) RB1 N258Efs11 [cytosol] (R-HSA-9688098) RB1 S182Ifs3 [cytosol] (R-HSA-9688099) RB1 Q436 [cytosol] (R-HSA-9662499) RB1 Q395Pfs11 [cytosol] (R-HSA-9688124) RB1 Y606Lfs47 [cytosol] (R-HSA-9688125) RB1 E539* [cytosol] (R-HSA-9662525) RB1 L317* [cytosol] (R-HSA-9688126) RB1 F104Lfs7 [cytosol] (R-HSA-9688127) RB1 E691 [cytosol] (R-HSA-9662527) RB1 D340Yfs5 [cytosol] (R-HSA-9688120) RB1 K740Tfs10 [cytosol] (R-HSA-9688121) RB1 H483Ifs12 [cytosol] (R-HSA-9688122) RB1 R611Lfs43 [cytosol] (R-HSA-9688123) RB1 V291Ifs9 [cytosol] (R-HSA-9688116) RB1 N133 [cytosol] (R-HSA-9688117) RB1 R334* [cytosol] (R-HSA-9688118) RB1 D697Qfs23 [cytosol] (R-HSA-9688119) RB1 L647Ffs5 [cytosol] (R-HSA-9688112) RB1 I723Nfs28 [cytosol] (R-HSA-9688113) RB1 L486Ifs6 [cytosol] (R-HSA-9688114) RB1 S565* [cytosol] (R-HSA-9688115) RB1 Y529Tfs3 [cytosol] (R-HSA-9688076) RB1 Q631 [cytosol] (R-HSA-9662476) RB1 S318Nfs13 [cytosol] (R-HSA-9688077) RB1 D856Efs17 [cytosol] (R-HSA-9688078) RB1 P595Lfs16 [cytosol] (R-HSA-9688079) RB1 P777Lfs33 [cytosol] (R-HSA-9688072) RB1 G310Dfs22 [cytosol] (R-HSA-9688073) RB1 P250Sfs20 [cytosol] (R-HSA-9688074) RB1 Q850* [cytosol] (R-HSA-9662474) RB1 I124Rfs6 [cytosol] (R-HSA-9688075) RB1 Q702 [cytosol] (R-HSA-9662475) RB1 E748Dfs6 [cytosol] (R-HSA-9688068) RB1 Q736 [cytosol] (R-HSA-9662468) RB1 R798Qfs4 [cytosol] (R-HSA-9688069) RB1 S588Ffs6 [cytosol] (R-HSA-9688070) RB1 K574* [cytosol] (R-HSA-9688071) RB1 D156Mfs19 [cytosol] (R-HSA-9688064) RB1 Y771Cfs23 [cytosol] (R-HSA-9688065) RB1 I66Dfs44 [cytosol] (R-HSA-9688066) RB1 Q685 [cytosol] (R-HSA-9662466) RB1 E125Kfs11 [cytosol] (R-HSA-9688067) RB1 Y655Lfs13 [cytosol] (R-HSA-9688092) RB1 R828Kfs10 [cytosol] (R-HSA-9688093) RB1 Y659Ifs4 [cytosol] (R-HSA-9688094) RB1 Q846* [cytosol] (R-HSA-9662494) RB1 E97Nfs14 [cytosol] (R-HSA-9688095) RB1 Q770 [cytosol] (R-HSA-9662495) RB1 C666* [cytosol] (R-HSA-9688088) RB1 Q471* [cytosol] (R-HSA-9662488) RB1 R71Efs39 [cytosol] (R-HSA-9688089) RB1 Q504 [cytosol] (R-HSA-9662489) RB1 R798Tfs17 [cytosol] (R-HSA-9688090) RB1 Q639 [cytosol] (R-HSA-9662490) RB1 N328* [cytosol] (R-HSA-9688091) RB1 S576Rfs34 [cytosol] (R-HSA-9688084) RB1 T726Nfs25 [cytosol] (R-HSA-9688085) RB1 Q597* [cytosol] (R-HSA-9662485) RB1 I532Nfs57 [cytosol] (R-HSA-9688086) RB1 K577Rfs34 [cytosol] (R-HSA-9688087) RB1 R73Sfs36 [cytosol] (R-HSA-9688080) RB1 E413Kfs4 [cytosol] (R-HSA-9688081) RB1 K844Sfs5 [cytosol] (R-HSA-9688082) RB1 A17Pfs3 [cytosol] (R-HSA-9688083) RB1 Q395* [cytosol] (R-HSA-9660655) RB1 L523* [cytosol] (R-HSA-9662176) RB1 R251* [cytosol] (R-HSA-9660640) RB1 L389* [cytosol] (R-HSA-9662178) RB1 Q217* [cytosol] (R-HSA-9660668) RB1 Q344* [cytosol] (R-HSA-9660669) RB1 S634* [cytosol] (R-HSA-9662207) RB1 S565* [cytosol] (R-HSA-9662200) RB1 S397* [cytosol] (R-HSA-9662202) RB1 S838* [cytosol] (R-HSA-9662203) RB1 R556* [cytosol] (R-HSA-9660661) RB1 R787* [cytosol] (R-HSA-9660656) RB1 G304* [cytosol] (R-HSA-9662152) RB1 W516* [cytosol] (R-HSA-9662660) RB1 W681* [cytosol] (R-HSA-9662661) RB1 E322* [cytosol] (R-HSA-9662149) RB1 W563* [cytosol] (R-HSA-9662656) RB1 L550* [cytosol] (R-HSA-9662173) RB1 R552* [cytosol] (R-HSA-9660637) RB1 L512* [cytosol] (R-HSA-9662168) RB1 R455* [cytosol] (R-HSA-9660632) RB1 R763* [cytosol] (R-HSA-9662681) RB1 L779* [cytosol] (R-HSA-9662169) RB1 R445* [cytosol] (R-HSA-9660633) RB1 R544* [cytosol] (R-HSA-9662677) RB1 R320* [cytosol] (R-HSA-9660630) RB1 L832* [cytosol] (R-HSA-9662167) RB1 Y498* [cytosol] (R-HSA-9662634) RB1 Y446* [cytosol] (R-HSA-9662628) RB1 Y655* [cytosol] (R-HSA-9662629) RB1 E323* [cytosol] (R-HSA-9662142) RB1 E364* [cytosol] (R-HSA-9662143) RB1 C489* [cytosol] (R-HSA-9662649) RB1 G310* [cytosol] (R-HSA-9662137) RB1 L335* [cytosol] (R-HSA-9662139) RB1 E313* [cytosol] (R-HSA-9662133) RB1 E315* [cytosol] (R-HSA-9662131) RB1 D479Vfs14 [cytosol] (R-HSA-9688204) RB1 C489Lfs5 [cytosol] (R-HSA-9688205) RB1 Y454* [cytosol] (R-HSA-9662605) RB1 E137Rfs3 [cytosol] (R-HSA-9688206) RB1 L676Ffs16 [cytosol] (R-HSA-9688207) RB1 Y728* [cytosol] (R-HSA-9662607) RB1 I799Ffs11 [cytosol] (R-HSA-9688200) RB1 D346Vfs17 [cytosol] (R-HSA-9688201) RB1 F514Pfs8 [cytosol] (R-HSA-9688202) RB1 N593Sfs5 [cytosol] (R-HSA-9688203) RB1 T58Yfs52 [cytosol] (R-HSA-9688196) RB1 N522Ifs2 [cytosol] (R-HSA-9688197) RB1 C553Vfs58 [cytosol] (R-HSA-9688198) RB1 P609Cfs43 [cytosol] (R-HSA-9688199) RB1 N269* [cytosol] (R-HSA-9688192) RB1 E287Rfs2 [cytosol] (R-HSA-9688193) RB1 E492Lfs4 [cytosol] (R-HSA-9688194) RB1 Q383Nfs3 [cytosol] (R-HSA-9688195) RB1 Y606 [cytosol] (R-HSA-9662617) RB1 Y756* [cytosol] (R-HSA-9662619) RB1 Y790* [cytosol] (R-HSA-9662612) RB1 T502Nfs17 [cytosol] (R-HSA-9688208) RB1 Y709 [cytosol] (R-HSA-9662608) RB1 Y749* [cytosol] (R-HSA-9662611) RB1 T738_R775del [nucleoplasm] (R-HSA-9661042) RB1 [cytosol] (R-HSA-9660621) hyperphosphorylated RB1 [nucleoplasm] (R-HSA-188389) p-S249-RB1 [nucleoplasm] (R-HSA-9687343) p-S230-RB1 [nucleoplasm] (R-HSA-9687336) p-T356-RB1 [nucleoplasm] (R-HSA-9687339) p-T826-RB1 [nucleoplasm] (R-HSA-9687334) p-S252-RB1 [nucleoplasm] (R-HSA-9687335) p-S807-RB1 [nucleoplasm] (R-HSA-9687356) p-T821-RB1 [nucleoplasm] (R-HSA-9687357) p-S795-RB1 [nucleoplasm] (R-HSA-69226) p-S612-RB1 [nucleoplasm] (R-HSA-9687352) p-S780-RB1 [nucleoplasm] (R-HSA-9687353) p-S811-RB1 [nucleoplasm] (R-HSA-9687354) RB1 [nucleoplasm] (R-HSA-68642) p-S788-RB1 [nucleoplasm] (R-HSA-9687347) p-S608-RB1 [nucleoplasm] (R-HSA-9687351) p-T373-RB1 [nucleoplasm] (R-HSA-9687355)	0.623	4
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q15256 PTPRR			0.556	3
UniProt:Q9H869 YYAP1			0.553	2
UniProt:Q15759 MAPK11	4	p-T180,Y182-MAPK11 [cytosol] (R-HSA-171009) MAPK11 [cytosol] (R-HSA-170989) MAPK11 [nucleoplasm] (R-HSA-203790) p-T180,Y182-MAPK11 [nucleoplasm] (R-HSA-198741)	0.547	2
UniProt:P68104 EEF1A1	7	EEF1A1 [cytosol] (R-HSA-156905) EEF1A1 [lysosomal membrane] (R-HSA-9626022) EEF1A1 [secretory granule lumen] (R-HSA-6801479) EEF1A1 [extracellular region] (R-HSA-6806456) EEF1A1 [ficolin-1-rich granule lumen] (R-HSA-6801528) Me3K318-EEF1A1 [cytosol] (R-HSA-8932419) Me3K79-EEF1A1 [cytosol] (R-HSA-8932212)	0.547	3
UniProt:Q9H0W5 CCDC8	1	CCDC8 [cytosol] (R-HSA-8955915)	0.527	2
UniProt:O75147 OBSL1	1	OBSL1 [cytosol] (R-HSA-8955929)	0.527	2
UniProt:P46940 IQGAP1	3	IQGAP1 [secretory granule membrane] (R-HSA-6804803) IQGAP1 [cytosol] (R-HSA-5626371) IQGAP1 [plasma membrane] (R-HSA-381681)	0.527	3
UniProt:P13639 EEF2	10	EEF2 [extracellular region] (R-HSA-6806499) EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) EEF2 [cytosol] (R-HSA-156901) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.527	2
UniProt:Q92574 TSC1	2	TSC1 [cytosol] (R-HSA-5672338) TSC1 [plasma membrane] (R-HSA-165169)	0.508	2
UniProt:Q99956 DUSP9	1	DUSP9 [cytosol] (R-HSA-5675351)	0.508	2
UniProt:Q07352 ZFP36L1	3	ZFP36L1 [cytosol] (R-HSA-450547) p-S54,S92,S203-p-ZFP36L1 [cytosol] (R-HSA-450384) p-S92,S203-ZFP36L1 [cytosol] (R-HSA-450618)	0.508	2

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