Reactome | ESRP1 [nucleoplasm]

ESRP1 [nucleoplasm]

Stable Identifier

R-HSA-6803472

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q6NXG1 ESRP1

Gene Names

ESRP1, RBM35A

Chain

chain:1-681

Reference Genes

BioGPS Gene:54845 ESRP1

COSMIC (genes):ESRP1 ESRP1

CTD Gene:54845 ESRP1

dbSNP Gene:54845 ESRP1

ENSEMBL:ENSG00000104413 ESRP1

ENSEMBL:ENSG00000104413.18 ESRP1

HGNC:25966 ESRP1

KEGG Gene (Homo sapiens):54845 ESRP1

Monarch:54845 ESRP1

NCBI Gene:54845 ESRP1

OMIM:612959 ESRP1

UCSC:Q6NXG1 ESRP1

Reference Transcript

Other Identifiers

11723543_a_at

11723544_a_at

17070949

219121_PM_s_at

219121_s_at

225846_PM_at

225846_at

3107549

3107550

3107552

3107554

3107555

3107563

3107564

3107565

3107566

3107567

3107568

3107570

3107571

3107578

3107585

3107586

3107587

3107590

3107593

3107594

3631959

50391_at

54845

8147351

82072_at

A_14_P135791

A_23_P259127

GE55386

GO:0003676

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0006397

GO:0008380

GO:0016071

GO:0016604

GO:0030154

GO:0042669

GO:0043226

GO:0043484

GO:0048856

GO:1990904

HMNXSV003048506

HMNXSV003056263

Hs.24743.1.A1_3p_at

ILMN_1749180

PH_hs_0002178

TC08000575.hg

g8923166_3p_a_at

Participates

as a component of

FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)

as an input of

ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)

Other forms of this molecule

ESRP1(1-606)-RAF1(227-648) fusion [cytosol]

ESRP1(1-606)-p-RAF1(227-648) fusion [cytosol]

Cross References

RefSeq

NP_001116297.1, XP_005251048.1, NP_060167.2, NP_001030087.2, NP_001116299.1, NP_001116298.1

OpenTargets

ENSG00000104413

HPA

ENSG00000104413-ESRP1

GeneCards

Q6NXG1

Ensembl

ENST00000423620, ENST00000433389, ENST00000646773, ENSP00000405738, ENSP00000494213, ENST00000358397, ENSP00000407349, ENSP00000351168, ENSG00000104413

PRO

Q6NXG1

Pharos - Targets

Q6NXG1

Orphanet

28885

PDB

7VKJ, 2DHA, 2RVJ, 7WRN, 7VKI

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P54253 ATX1			0.805	12
UniProt:P22607 FGFR3	20	FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane] (R-HSA-8853144) FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane] (R-HSA-8853131) FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane] (R-HSA-8853152) FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane] (R-HSA-8853124) FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane] (R-HSA-8853125) FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane] (R-HSA-8853127) FGFR3 K650T [plasma membrane] (R-HSA-1614411) FGFR3 K650N [plasma membrane] (R-HSA-1614406) FGFR3 K650M [plasma membrane] (R-HSA-1614402) FGFR3 K650Q [plasma membrane] (R-HSA-1614410) FGFR3 A391E [plasma membrane] (R-HSA-1614390) FGFR3 K650E [plasma membrane] (R-HSA-1614400) FGFR3 G380R [plasma membrane] (R-HSA-1614398) FGFR3 G382D [plasma membrane] (R-HSA-2018740) FGFR3 805fs*141 [plasma membrane] (R-HSA-1614387) FGFR3 [plasma membrane] (R-HSA-2038357) FGFR3 S371C [plasma membrane] (R-HSA-1614421) FGFR3 Y373C [plasma membrane] (R-HSA-1614424) FGFR3 G370C [plasma membrane] (R-HSA-1614394) FGFR3 R248C [plasma membrane] (R-HSA-1614419)	0.556	3
UniProt:Q6ZRY4 RBPS2			0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:P13637 ATP1A3	1	ATP1A3 [plasma membrane] (R-HSA-936803)	0.556	3
UniProt:Q9Y649 Q9Y649			0.556	3
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.556	3
IntAct:EBI-25857482 CCSB			0.556	3
UniProt:Q96G42 KLD7B			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:Q15038 DAZP2			0.556	3
UniProt:Q3LI72 KRTAP19-5	1	KRTAP19-5 [cytosol] (R-HSA-6810300)	0.556	3
UniProt:P08670 VIM	11	VIM(2-85) [cytosol] (R-HSA-350264) VIM(86-466) [cytosol] (R-HSA-350294) VIM(430-466) [cytosol] (R-HSA-350316) VIM(2-429) [cytosol] (R-HSA-350317) VIM(260-466) [cytosol] (R-HSA-350314) VIM(2-259) [cytosol] (R-HSA-350323) VIM [cytosol] (R-HSA-201600) Vimentin [late endosome lumen] (R-HSA-9660019) Vimentin [microtubule organizing center] (R-HSA-9657898) Vimentin [cytosol] (R-HSA-9646687) Vimentin [lysosomal lumen] (R-HSA-9659977)	0.556	3
UniProt:Q9UMX0 UBQLN1	1	UBQLN1 [cytosol] (R-HSA-8866006)	0.556	3
UniProt:Q03989 ARI5A			0.556	3
UniProt:P04792 HSPB1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.556	3
UniProt:Q13393 PLD1	4	PLD1 [tertiary granule membrane] (R-HSA-6800955) PLD1 [specific granule membrane] (R-HSA-6799531) PLD1 [plasma membrane] (R-HSA-2028998) PLD1 [endoplasmic reticulum membrane] (R-HSA-1498795)	0.556	3
UniProt:P86480 PR20D			0.556	3
UniProt:Q86V38 Q86V38			0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:P28329-3 P283293			0.556	3
UniProt:P48643 CCT5	1	CCT5 [cytosol] (R-HSA-390447)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:O14901 KLF11			0.556	3
UniProt:P16284 PECAM1	4	PECAM1 [plasma membrane] (R-HSA-114686) PECAM1 [secretory granule membrane] (R-HSA-6804778) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [platelet alpha granule membrane] (R-HSA-61489)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:Q14203-5 DCTN1			0.556	3
IntAct:EBI-25847655 CCSB			0.556	3
UniProt:P02766 TTR	2	TTR [extracellular region] (R-HSA-976883) TTR [azurophil granule lumen] (R-HSA-6799366)	0.556	3
UniProt:Q13148 TADBP			0.556	6
UniProt:P00488 F13A1	4	factor XIIIa A chain [extracellular region] (R-HSA-140788) factor XIII A chain [extracellular region] (R-HSA-140600) factor XIII A chain activation peptide [extracellular region] (R-HSA-140790) F13A1(1-731) [platelet alpha granule lumen] (R-HSA-349759)	0.556	3
UniProt:P34741 SDC2	20	SDC2 [plasma membrane] (R-HSA-2090052) p-Y179,Y191-SDC2 [plasma membrane] (R-HSA-4093306) SDC2 [lysosomal lumen] (R-HSA-2090083) HS(6)-SDC2 [lysosomal lumen] (R-HSA-2090064) HS(2)-SDC2 [Golgi lumen] (R-HSA-2076603) HS(3)-SDC2 [Golgi lumen] (R-HSA-2076443) HS(4)-SDC2 [Golgi lumen] (R-HSA-2076356) HS(6)-SDC2 [Golgi lumen] (R-HSA-2076588) HS(5)-SDC2 [Golgi lumen] (R-HSA-2076320) HS(1)-SDC2 [Golgi lumen] (R-HSA-2076607) Heparan(4)-SDC2 [Golgi lumen] (R-HSA-2076576) Heparan(3)-SDC2 [Golgi lumen] (R-HSA-2076361) Heparan(2)-SDC2 [Golgi lumen] (R-HSA-2076397) Heparan(1)-SDC2 [Golgi lumen] (R-HSA-2076536) Heparan-SDC2 [Golgi lumen] (R-HSA-2076608) GlcA-Gal-Gal-Xyl-SDC2 [Golgi lumen] (R-HSA-2063997) HS(4)-SDC2 [plasma membrane] (R-HSA-2076683) HS(6)-SDC2 [plasma membrane] (R-HSA-2076661) HS(2)-SDC2 [plasma membrane] (R-HSA-2076644) HS(1)-SDC2 [plasma membrane] (R-HSA-2076643)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q8TDS5 OXER1	1	OXER1 [plasma membrane] (R-HSA-416425)	0.556	3
UniProt:Q71SY5 MED25	1	MED25 [nucleoplasm] (R-HSA-212414)	0.556	3

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