TP53 binds ZNF385A

Stable Identifier
R-HSA-6803719
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

ZNF385A (HZF) forms a complex with TP53 (p53), interacting with the DNA binding domain of TP53. The complex of TP53 and ZNF385A associates with p53 response elements of cell cycle arrest genes, such as CDKN1A (p21) and stimulates their transcription. Under prolonged stress, ZNF385A undergoes ubiquitination and proteasome-mediated degradation, which coincides with expression of TP53-regulated pro-apoptotic genes (Das et al. 2007).

Literature References
PubMed ID Title Journal Year
17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

Das, S, Raj, L, Zhao, B, Kimura, Y, Bernstein, A, Aaronson, SA, Lee, SW

Cell 2007
Participants
Participant Of
Orthologous Events
Authored
Reviewed