TP53 in complex with ZNF385A binds the CDKN1A promoter

Stable Identifier
R-HSA-6803801
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TP53 (p53) binds at least two p53 response elements in the promoter of the CDKN1A (p21, WAF1) gene (El-Deiry et al. 1993, Espinosa et al. 2003). Formation of the complex of TP53 and ZNF385A (HZF) facilitates binding of TP53 to the CDKN1A promoter (Das et al. 2007).

Literature References
PubMed ID Title Journal Year
8242752 WAF1, a potential mediator of p53 tumor suppression.

el-Deiry, WS, Tokino, T, Velculescu, VE, Levy, DB, Parsons, R, Trent, JM, Lin, D, Mercer, WE, Kinzler, KW, Vogelstein, B

Cell 1993
14580351 p53 functions through stress- and promoter-specific recruitment of transcription initiation components before and after DNA damage

Espinosa, JM, Verdun, RE, Emerson, BM

Mol. Cell 2003
17719541 Hzf Determines cell survival upon genotoxic stress by modulating p53 transactivation

Das, S, Raj, L, Zhao, B, Kimura, Y, Bernstein, A, Aaronson, SA, Lee, SW

Cell 2007
Participants
Participant Of
Authored
Reviewed
Created