Reactome: A Curated Pathway Database

SFN dimer binds BAX

Stable Identifier
R-HSA-6803892
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

SFN (14-3-3-sigma) dimer forms a complex with BAX. Binding of SFN to BAX prevents BAX translocation from cytosol to mitochondria, thus inhibiting cytochrome C release and apoptosis. SFN therefore promotes G2 cell cycle arrest while simultaneously preventing apoptosis (Samuel et al. 2001).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events