TP53 stimulates PLAGL1 expression

Stable Identifier
R-HSA-6803946
Type
Reaction [omitted]
Species
Homo sapiens
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Binding of TP53 (p53) to the p53 response element in the promoter of the PLAGL1 (ZAC1) gene stimulates PLAGL1 transcription (Rozenfeld-Granot et al. 2002). PLAGL1 is a zinc finger protein implicated in transcriptional regulation. PLAGL1 expression correlates with both cell cycle arrest and apoptosis (Spengler et al. 1997) and is frequently lost in cancer (Varrault et al. 1998). The mechanism of PLAGL1 action requires further elucidation.

Literature References
PubMed ID Title Journal Year
11896574 A positive feedback mechanism in the transcriptional activation of Apaf-1 by p53 and the coactivator Zac-1

Rozenfeld-Granot, G, Krishnamurthy, J, Kannan, K, Toren, A, Amariglio, N, Givol, D, Rechavi, G

Oncogene 2002
9184226 Regulation of apoptosis and cell cycle arrest by Zac1, a novel zinc finger protein expressed in the pituitary gland and the brain

Spengler, D, Villalba, M, Hoffmann, A, Pantaloni, C, Houssami, S, Bockaert, J, Journot, L

EMBO J. 1997
9671765 hZAC encodes a zinc finger protein with antiproliferative properties and maps to a chromosomal region frequently lost in cancer

Varrault, A, Ciani, E, Apiou, F, Bilanges, B, Hoffmann, A, Pantaloni, C, Bockaert, J, Spengler, D, Journot, L

Proc. Natl. Acad. Sci. U.S.A. 1998
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