TP53 binds the complex of JMY, EP300 and TTC5

Stable Identifier
R-HSA-6804242
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

The complex of JMY, EP300 (p300) and TTC5 (Strap) associates with stabilized TP53 (p53) and enhances transcription of pro-apoptotic TP53 targets, such as BAX (Shikama et al. 1999, Demonacos et al. 2001).

Literature References
PubMed ID Title Journal Year
11511361 A TPR motif cofactor contributes to p300 activity in the p53 response

Demonacos, C, Krstic-Demonacos, M, La Thangue, NB

Mol. Cell 2001
10518217 A novel cofactor for p300 that regulates the p53 response

Shikama, N, Lee, CW, France, S, Delavaine, L, Lyon, J, Krstic-Demonacos, M, La Thangue, NB

Mol. Cell 1999
22362889 The p53 cofactor Strap exhibits an unexpected TPR motif and oligonucleotide-binding (OB)-fold structure

Adams, CJ, Pike, AC, Maniam, S, Sharpe, TD, Coutts, AS, Knapp, S, La Thangue, NB, Bullock, AN

Proc. Natl. Acad. Sci. U.S.A. 2012
Participants
Participant Of
Orthologous Events
Authored
Reviewed