MDM2 ubiquitinates JMY

Stable Identifier
R-HSA-6804253
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MDM2 can bind and ubiquitinate JMY, a transcriptional co-factor of TP53 (p53), thus targeting it for proteasome-mediated degradation (Coutts et al. 2007).

Literature References
PubMed ID Title Journal Year
17170761 Mdm2 targets the p53 transcription cofactor JMY for degradation EMBO Rep. 2007
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm]
Physical Entity
Activity
Orthologous Events