Reactome: A Curated Pathway Database

MDM2 ubiquitinates JMY

Stable Identifier
R-HSA-6804253
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

MDM2 can bind and ubiquitinate JMY, a transcriptional co-factor of TP53 (p53), thus targeting it for proteasome-mediated degradation (Coutts et al. 2007).

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
This entity is regulated by:
Title Physical Entity Activity
ubiquitin protein ligase activity of p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2:MDM4 [nucleoplasm] ubiquitin protein ligase activity (0061630)
Orthologous Events